Results 31 to 40 of about 3,281 (176)

Kidney ischemia and reperfunsion syndrome: effect of lidocaine and local postconditioning

Revista do Colégio Brasileiro de Cirurgiões
Objective: to evaluate the effects of blocking the regulation of vascular tone on the ischemia and reperfusion syndrome in rats through the use of lidocaine in the postconditioning technique.
IGOR NAGAI YAMAKI, RUY VICTOR SIMÕES PONTES, FELIPE LOBATO DA SILVA COSTA, VITOR NAGAI YAMAKI, RENAN KLEBER COSTA TEIXEIRA, EDSON YUZUR YASOJIMA, MARCUS VINICIUS HENRIQUES BRITO   +6 more
doaj   +1 more source

Ischemic postconditioning: a clinical perspective

Interventional Cardiology, 2010
Primary percutaneous coronary intervention is the recommended therapy for patients with ST‑elevation myocardial infarction. However, restoration of coronary blood flow may lead to reperfusion injury, which has been suggested to account for 50% of the final myocardial infarct size.
Lønborg, Jacob, Treiman, Marek, Engstrøm, Thomas   +2 more
openaire   +1 more source

High plasma concentrations of asymmetric dimethylarginine inhibit ischemic cardioprotection in hypercholesterolemic rats

Brazilian Journal of Medical and Biological Research, 2013
A low concentration of nitric oxide associated with a high concentration of asymmetric dimethylarginine (ADMA) can explain the lack of ischemic cardioprotection observed in the presence of hypercholesterolemia.
M.B.P. Landim, P.M.M. Dourado, A. Casella-Filho, A.C.P. Chagas, P.L. da-Luz   +4 more
doaj   +3 more sources

Pharmacological postconditioning: a molecular aspect in ischemic injury

Journal of Pharmacy and Pharmacology, 2020
Abstract Objective Ischaemia/reperfusion (I/R) injury is defined as the damage to the tissue which is caused when blood supply returns to tissue after ischaemia. To protect the ischaemic tissue from irreversible injury, various protective agents have been studied but the benefits have not been ...
Heena Khan, Ankita Kashyap, Amarjot Kaur, Thakur Gurjeet Singh   +3 more
openaire   +2 more sources

Ischemic postconditioning alters the gene expression pattern of the ischemic heart

Experimental Biology and Medicine, 2014
To profile changes in gene expression in response to ischemic postconditioning, isolated rat hearts were subjected to 30 min of regional ischemia followed by 120 min of reperfusion with or without postconditioning. At the end of reperfusion, cardiac RNA was assayed by DNA microarrays (31,000 format), verified by quantitative real-time polymerase chain ...
Csonka, Csaba, Szűcs, Gergő, Varga-Orvos, Zoltán, Bencsik, Péter, Csont, Tamás Bálint, Zvara, Ágnes, Puskás, László, Ferdinandy, Péter   +7 more
openaire   +3 more sources

Very short cycles of postconditioning have no protective effect against reperfusion injury. Experimental study in rats

Brazilian Journal of Cardiovascular Surgery, 2014
Introduction: Ischemic postconditioning has been recognized as effective in the prevention of reperfusion injury in situations of ischemia and reperfusion in various organs and tissues. However, it remains unclear what would be the best way to accomplish
Ricardo Kenithi Nakamura, Carlos Henrique Marques dos Santos, Luciana Nakao Odashiro Miiji, Mariana Sousa Arakaki, Cristiane Midori Maedo, Maurício Érnica Filho, Pedro Carvalho Cassino, Elenir Rose Jardim Cury Pontes   +7 more
doaj   +1 more source

Combined postconditioning with ischemia and cyclosporine-A restore oxidative stress and histopathological changes in reperfusion injury of diabetic myocardium [PDF]

Iranian Journal of Basic Medical Sciences, 2017
Objective(s): Chronic diabetes impedes cardioprotection in reperfusion injury and hence protecting the diabetic heart would have important outcomes.
Reza Badalzadeh, Seyed Mahmoud Tabatabaei, Mustafa Mohammadi, Arash Khaki, Dariush Mohammadnezhad   +4 more
doaj   +1 more source

Ischemic postconditioning: mechanisms, comorbidities, and clinical application

Molecular and Cellular Biochemistry, 2014
Since ischemic heart disease (IHD) is a major cause of mortality and heart failure, novel therapeutic strategies are expected to improve the clinical outcomes of patients with acute myocardial infarction. Brief episodes of ischemia/reperfusion performed at the onset of reperfusion can reduce infarct size; a phenomenon termed "ischemic postconditioning."
Buchholz, Bruno, Donato, Pablo Martín, D'Anunzio, Verónica, Gelpi, Ricardo Jorge   +3 more
openaire   +3 more sources

From Rapid to Delayed and Remote Postconditioning: The Evolving Concept of Ischemic Postconditioning in Brain Ischemia [PDF]

Current Drug Targets, 2012
Ischemic postconditioning is a concept originally defined to contrast with that of ischemic preconditioning. While both preconditioning and postconditioning confer a neuroprotective effect on brain ischemia, preconditioning is a sublethal insult performed in advance of brain ischemia, and postconditioning, which conventionally refers to a series of ...
Shen, J, Zhao, H, Chen, X, Ren, C
openaire   +4 more sources

Quercetin in Myocardial Ischemia–Reperfusion Injury: Mechanistic Evidence, Cardioprotective Effects, and Translational Challenges

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Quercetin mitigates myocardial ischemia–reperfusion injury through coordinated antioxidant, anti‐inflammatory, and anti‐apoptotic mechanisms, leading to reduced infarct size and improved cardiac function. Its multi‐target cardioprotective effects highlight quercetin as a promising therapeutic candidate for ischemic heart disease.
Rony Abdi Syahputra, Princella Halim, Sasniwiati Sari Hasibuan, Adhayani Lubis   +3 more
wiley   +1 more source