Results 31 to 40 of about 10,945 (163)

Transfer of Cardiac Mitochondria Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in a Preclinical Model of Ischemic Heart Disease

Cells, 2023
Background: The use of mesenchymal stem cells (MSCs) appears to be a promising therapeutic approach for cardiac repair after myocardial infarction. However, clinical trials have revealed the need to improve their therapeutic efficacy.
Marie-Luce Vignais, Jennyfer Levoux, Pierre Sicard, Khattar Khattar, Catherine Lozza, Marianne Gervais, Safia Mezhoud, Jean Nakhle, Frederic Relaix, Onnik Agbulut, Jeremy Fauconnier, Anne-Marie Rodriguez   +11 more
doaj   +1 more source

A practical approach to remote ischemic preconditioning and ischemic preconditioning against myocardial ischemia/reperfusion injury

Journal of Biological Methods, 2016
Although urgently needed in clinical practice, a cardioprotective therapeutic approach against myocardial ischemia/reperfusion injury remains to be established. Remote ischemic preconditioning (rIPC) and ischemic preconditioning (IPC) represent promising tools comprising three entities: the generation of a protective signal, the transfer of the signal ...
Totzeck, Matthias, Hendgen-Cotta, Ulrike B., French, Brent A., Rassaf, Tienush   +3 more
openaire   +3 more sources

Optimizing Donor Kidneys During Normothermic Machine Perfusion With Sevoflurane: Design of a Research Model

Artificial Organs, EarlyView.
A stable kidney normothermic machine perfusion model with sevoflurane delivery via a vaporizer was established, enabling mechanistic and therapeutic studies of ischemia–reperfusion injury. ABSTRACT Normothermic machine perfusion (NMP) of donor kidneys provides an opportunity not only for organ preservation but also for therapeutic intervention to ...
Philip N. Günkel, Shuqi Yang, Rozemarijn S. Tuinhout, Sebastiaan J. Luttik, Roland F. Hoffmann, Petra J. Ottens, Damien Richard, Matthieu Jabaudon, Michel M. R. F. Struys, Henri G. D. Leuvenink, Gertrude J. Nieuwenhuijs‐Moeke   +10 more
wiley   +1 more source

Role of microtubules in ischemic preconditioning against myocardial infarction [PDF]

Cardiovascular Research, 2004
The role of microtubules in ischemic preconditioning (PC) was investigated in isolated perfused rabbit hearts.Myocardial infarction was induced by 30-min global ischemia and 2-h reperfusion, and infarct size was expressed as a percentage of the left ventricle (%IS/LV).
Yuichi, Nakamura, Tetsuji, Miura, Atsushi, Nakano, Yoshihiko, Ichikawa, Toshiyuki, Yano, Hironori, Kobayashi, Yoshihiro, Ikeda, Takayuki, Miki, Kazuaki, Shimamoto   +8 more
openaire   +2 more sources

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, EarlyView.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source

Remote and Anesthetic-Induced Myocardial Preconditioning Is Preserved in Atherosclerotic LDL Receptor-/- Mice In Vivo

Cardiovascular Therapeutics, 2021
Introduction. In the animal model, preconditioning is a powerful weapon against ischemic damage. The reason why the human heart cannot be protected from ischemic damage by preconditioning remains unclear.
Walter Petermichl, Kathrin Eglmeier, Henriette Hesse, Michael Gruber, Bernhard Graf, Andre Bredthauer, Andreas Redel   +6 more
doaj   +1 more source

Low‐dose X‐ray radiation induces an adaptive response: A potential countermeasure to galactic cosmic radiation exposure

Experimental Physiology, EarlyView.
Abstract Space exploration involves many dangers including galactic cosmic radiation (GCR). This class of radiation includes high‐energy protons and heavy ionizing ions. NASA has defined GCR as a carcinogenic risk for long‐duration space missions. To date, no clear strategy has been developed to counter chronic GCR exposure.
Siena Edwards, Jessica Adams, Anastasia Tchernikov, John G. Edwards   +3 more
wiley   +1 more source

Bilateral remote ischemic conditioning in children: A two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgeryCentral MessagePerspective

JTCVS Open
Objective: The study objective was to determine whether adequately delivered bilateral remote ischemic preconditioning is cardioprotective in young children undergoing surgery for 2 common congenital heart defects with or without cyanosis.
Nigel E. Drury, PhD, FRCS(CTh), Carin van Doorn, MD, FRCS(CTh), Rebecca L. Woolley, MSc, Rebecca J. Amos-Hirst, MSc, Rehana Bi, BSc(Hons), Collette M. Spencer, BSc(Hons), Kevin P. Morris, MD, FRCPCH, James Montgomerie, MD, FRCA, John Stickley, BSc, Adrian Crucean, MD, Alicia Gill, MSc, Matt Hill, MSc, Ralf J.M. Weber, PhD, Lukas Najdekr, PhD, Andris Jankevics, PhD, Andrew D. Southam, PhD, Gavin R. Lloyd, PhD, Osama Jaber, MD, Imre Kassai, PhD, Giuseppe Pelella, MD, Natasha E. Khan, MD, FRCS(CTh), Phil Botha, PhD, FRCS(CTh), David J. Barron, MD, FRCS(CTh), Melanie Madhani, PhD, Warwick B. Dunn, PhD, Natalie J. Ives, MSc, Paulus Kirchhof, MD, Timothy J. Jones, MD, FRCS(CTh), Edmund D. Carver, Alistair J. Cranston, Fraser Harban, Vasco Laginha Rolo, Ritchie Marcus, Anthony Moriarty, Raju Reddy, Susanna N. Ritchie-McLean, Monica A. Stokes, Ayngara Thillaivasan, Nandlal Bhatia, Carol Bodlani, Wendy Lim, Joe Mellor, Jutta Scheffczik   +42 more
doaj   +1 more source

Cardioprotection via vagus nerve stimulation preconditioning: Reducing ischaemia–reperfusion injury and arrhythmic risk

Experimental Physiology, EarlyView.
Abstract Acute myocardial infarction is a leading cause of morbidity and mortality, with ischaemia–reperfusion (I/R) injury exacerbating myocardial damage. Vagus nerve stimulation (VNS) has been reported to exert cardioprotective effects, but its efficacy in preconditioning against I/R injury requires further investigation.
Feng Hu, Yali Wang, Guangyu Li, Guangyu Wang, Qi Zhuang, Jinyao Jiang, Danfeng Hu, Lihui Zheng, Yan Yao, Minhua Zang, Jun Pu   +10 more
wiley   +1 more source

Improved resistance to ischemia and reperfusion, but impaired protection by ischemic preconditioning in patients with type 1 diabetes mellitus: a pilot study

Cardiovascular Diabetology, 2012
Background In patients with type 1 diabetes mellitus (T1DM), cardiovascular events are more common, and the outcome following a myocardial infarction is worse than in nondiabetic subjects.
Engbersen Richard, Riksen Niels P, Mol Marc J, Bravenboer Bert, Boerman Otto C, Meijer Patrick, Oyen Wim JG, Tack Cees, Rongen Gerard A, Smits Paul   +9 more
doaj   +1 more source