Results 91 to 100 of about 50,595 (277)

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Mechanisms of Volatile Anesthetic-Induced Myocardial Protection [PDF]

, 2003
Volatile anesthetics protect myocardium against reversible and irreversible ischemic injury. Experimental evidence from several in vitro and in vivo animal models demonstrates that volatile agents enhance the recovery of stunned myocardium and reduce the
Gu, Weidong, Kersten, Judy R., LaDisa, John F., Ludwig, Lynda M., Pagel, Paul S., Tanaka, Katsuya, Warltier, David C.   +6 more
core   +1 more source

Vascularised Brain Organoids: Engineering Strategies and Neurobiological Applications

Cell Proliferation, EarlyView.
This review highlights emerging strategies to engineer vascularized brain organoids—including endothelial co‐culture, genetic induction, perfusion systems, and in vivo transplantation—and their applications in modelling neurovascular diseases, evaluating BBB drug delivery, and advancing regenerative medicine.
Yeajin Song, Hyejin Jo, Seokchan Jeong, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Brain ischemia alters platelet ATP diphosphohydrolase and 5'-nucleotidase activities in naive and preconditioned rats

Brazilian Journal of Medical and Biological Research, 2000
The effects of transient forebrain ischemia, reperfusion and ischemic preconditioning on rat blood platelet ATP diphosphohydrolase and 5'-nucleotidase activities were evaluated. Adult Wistar rats were submitted to 2 or 10 min of single ischemic episodes,
S.S. Frassetto, M.R.C. Schetinger, R. Schierholt, A. Webber, C.D. Bonan, A.T. Wyse, R.D. Dias, C.A. Netto, J.J.F. Sarkis   +8 more
doaj   +1 more source

IL‐6 in the spotlight: From cardiovascular pathophysiology to therapy

European Journal of Clinical Investigation, EarlyView.
Interleukin‐6 (IL‐6) links inflammation to cardiovascular and multi‐organ dysfunction. This review integrates mechanistic, translational, and clinical evidence supporting IL‐6 as both a biomarker and therapeutic target in the continuum of cardiovascular and cardio‐renal disease.
Alberto Preda, Amedeo Tirandi, Giulio Leo, Davide Di Vece, Gemma Vilahur, Aldo Bonaventura, Elena Osto, Stefano Ministrini, Simon Kraler, Petra Kleinbogard, Giovanni Camici, Federico Carbone, Fabrizio Montecucco, Luca Liberale   +13 more
wiley   +1 more source

Alternation of gene expression in brain-derived exosomes after cerebral ischemic preconditioning in mice

Heliyon
Aims: Cerebral ischemic preconditioning is a neuroprotective therapy against cerebral ischemia and ischemia-reperfusion injury. This study aims to demonstrate the alternation of gene expression in exosomes from brain tissue of mice after ischemic ...
He Li, Xiaoxi Zhang, Hongye Xu, Hanchen Liu, Yongxin Zhang, Lei Zhang, Yu Zhou, Yongwei Zhang, Jianmin Liu, Mei Jing, Ping Zhang, Pengfei Yang   +11 more
doaj   +1 more source

Additive Effect on Survival of Anaesthetic Cardiac Protection and Remote Ischemic Preconditioning in Cardiac Surgery: A Bayesian Network Meta-Analysis of Randomized Trials.

PLoS ONE, 2015
IntroductionCardioprotective properties of volatile agents and of remote ischemic preconditioning have survival effects in patients undergoing cardiac surgery.
Alberto Zangrillo, Mario Musu, Teresa Greco, Ambra Licia Di Prima, Andrea Matteazzi, Valentina Testa, Pasquale Nardelli, Daniela Febres, Fabrizio Monaco, Maria Grazia Calabrò, Jun Ma, Gabriele Finco, Giovanni Landoni   +12 more
doaj   +1 more source

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection [PDF]

, 2004
Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling.
Duchen, M, Hausenloy, D, Wynne, A, Yellon, D   +3 more
core   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, EarlyView.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source

Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-akt pathway [PDF]

, 2004
Brief intermittent episodes of ischemia and reperfusion, at the onset of reperfusion after a prolonged period of ischemia, confer cardioprotection, a phenomenon termed "ischemic postconditioning" (Postcond).
Hausenloy, D.J., Mocanu, M.M., Tsang, A., Yellon, D.M.   +3 more
core