Results 111 to 120 of about 42,902 (229)

Unveiling protective mechanisms of wild olive (acebuche) oil in retinal pigment epithelial cells with hypertensive phenotype

The Journal of Physiology, EarlyView.
Abstract figure legend Circulating extracellular vesicles (EVs) derived from acebuche (ACE) oil‐ and extra virgin olive oil (EVOO)‐fed mice modulate nitric oxide (NO) metabolism in the retinal pigment epithelial cell line (ARPE19) with a hypertensive phenotype induced by angiotensin II (AngII).
Álvaro Santana‐Garrido, Claudia Reyes‐Goya, Pablo Espinosa‐Martín, Rosa M. Troya‐Toledo, Helder André, Alfonso Mate, Carmen M. Vázquez   +6 more
wiley   +1 more source

The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection—evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology [PDF]

, 2018
Due to its poor capacity for regeneration, the heart is particularly sensitive to the loss of contractile cardiomyocytes. The onslaught of damage caused by ischaemia and reperfusion, occurring during an acute myocardial infarction and the subsequent ...
A Ames 3rd, A Carvalho, A Gaspar, A Maulik, AA Neuhaus, AC Schinzel, AD Sloth, Arjun K. Ghosh, AS Hazell, B Ibanez, B Ibanez, Borja Ibanez, CC Smith, CE Murry, CP Baines, D Li, Daniel I. Bromage, Derek M. Yellon, DI Bromage, DJ Hausenloy, DJ Hausenloy, DJ Hausenloy, DJ Hausenloy, DJ Hausenloy, ET Chouchani, F Chauveau, F Chen, F Pedersen, G Heusch, G Heusch, G Heusch, G Heusch, G Heusch, G Heusch, G Heusch, G Heusch, G Heusch, G Heusch, G Heusch, GA Donnan, GA Donnan, Gerd Heusch, GF Baxter, GP Fadini, GW Stone, H Sandhu, HA Cabrera-Fuentes, Hans Erik Bøtker, HE Botker, Helen Maddock, I Eitel, J Aronowski, J Astrup, J Bai, J Inserte, J Johnsen, JC Wang, JE Jung, JL Saver, JM Vicencio, John Cunningham, JP Audia, JPG Sluijter, JS Balami, JV McGowan, K Szummer, KL Furie, L Zhang, M Fisher, M Gharanei, M Gharanei, M Schmidt, M Thielmann, Malcolm Walker, Marlene Wiart, Maryna V. Basalay, MD Ginsberg, Michel Ovize, MV Cohen, N Nighoghossian, P Kleinbongard, P Meybohm, PA Lapchak, PA Lapchak, Petra Kleinbongard, R Bell, R Bonita, R Chung, R Madonna, RA Kloner, Richard D. Carr, RM Bell, RM Bell, Robert M. Bell, RR Liu, RR Moustafa, S Lecour, S Pundik, SA Crone, Sandrine Lecour, Sapna Arjun, Sean M. Davidson, SI Savitz, SM Davidson, SM Davidson, SM Davidson, SM Davidson, SP Jones, TA Zelniker, VE O’Collins, VE O’Collins, VL Feigin, W Li, X Rossello, X Rossello, X Xu, Y Li, Z Vermeulen   +117 more
core   +6 more sources

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

The challenge of translating ischemic conditioning from animal models to humans: the role of comorbidities

Disease Models & Mechanisms, 2014
Following a period of ischemia (local restriction of blood supply to a tissue), the restoration of blood supply to the affected area causes significant tissue damage.
Kieran McCafferty, Suzanne Forbes, Christoph Thiemermann, Muhammad M. Yaqoob   +3 more
doaj   +1 more source

Two Weeks of Ischemic Conditioning Improves Walking Speed and Reduces Neuromuscular Fatigability in Chronic Stroke Survivors [PDF]

, 2019
This pilot study examined whether ischemic conditioning (IC), a noninvasive, cost-effective, and easy-to-administer intervention, could improve gait speed and paretic leg muscle function in stroke survivors. We hypothesized that 2 wk of IC training would
Alqahtani, Saad Z., Boerger, Timothy F., Durand, Matthew J., Gutterman, David D., Hyngstrom, Allison S., Nguyen, Jennifer, Schmit, Brian D., Wright, Michael T.   +7 more
core   +1 more source

Blistering barnacles: Space physiology in The Adventures of Tintin

Experimental Physiology, EarlyView.
Jacob P. Hartmann, Mathis B. Mottelson, Rasmus H. Dahl, Ronni R. Plovsing, Ronan M. G. Berg   +4 more
wiley   +1 more source

Remote ischemic preconditioning and its role in the prevention of new onset atrial fibrillation post‐cardiac surgery. A meta‐analysis of randomized control trials

Journal of Arrhythmia, 2019
Background The denouement of remote ischemic preconditioning on new onset atrial fibrillation (NOAF) post‐cardiac surgery is not well‐established.
Ashish Kumar, Harpreet Singh, Mariam Shariff   +2 more
doaj   +1 more source

Effect of Staged Preconditioning on BiochemicalMarkers in the Patients Undergoing Coronary Artery Bypass Grafting [PDF]

The present study has investigated the effectiveness of staged-preconditioning, in both remote and target organs. After IP the myocardial release of the biochemicalmarkers including, creatine phosphokinase (CPK), cardiac creatine kinase (CK-MB ...
باباپور, بهزاد, جعفری, ناصر, حسن پور, محمد, حسینیان, عدالت, دوستکامی, حسین, محمدزاده, علیرضا   +5 more
core   +3 more sources

Age-related reduction of cerebral ischemic preconditioning: myth or reality?

Clinical Interventions in Aging, 2013
David Della-Morte,1,2 Francesco Cacciatore,3 Elisa Salsano,4 Gilda Pirozzi,4 Maria Teresa Del Genio,4 Iole D'Antonio,4 Gaetano Gargiulo,5 Raffaele Palmirotta,2 Fiorella Guadagni,2 Tatjana Rundek,1 Pasquale Abete41Department of Neurology, Miller ...
Della-Morte D, Caciatore F, Salsano E, Pirozzi G, Del Genio MT, D'Antonio I, Gargiulo G, Palmirotta R, Guadagni F, Rundek T, Abete P   +10 more
doaj