Results 51 to 60 of about 63,266 (244)

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

Targeting Arginase 1 but Not Arginase 2 Protects from Myocardial Ischemia–Reperfusion Injury via Nitric Oxide Signaling by Red Blood Cells in Type 2 Diabetes

Antioxidants
Background: Arginase influences cardiac tolerance to ischemia–reperfusion by modulating nitric oxide (NO) signaling. In type 2 diabetes (T2D), elevated arginase activity may worsen ischemic injury through red blood cells (RBCs), but the specific roles of
Jiangning Yang, Yahor Tratsiakovich, Renhai Cao, Ali Mahdi, Gianluigi Pironti, Tong Jiao, Rawan Humoud, Eftychia Kontidou, John Tengbom, Aida Collado, Zhichao Zhou, Yihai Cao, Eleonore Köhler, Adam E. Mullick, John Pernow   +14 more
doaj   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Ischemic Preconditioning Alters the Epigenetic Profile of the Brain from Ischemic Intolerance to Ischemic Tolerance [PDF]

Neurotherapeutics, 2013
Ischemic preconditioning is an innate neuroprotective mechanism in which a sub-injurious ischemic exposure increases the brain's ability to withstand a subsequent, normally injurious ischemic insult. Part of ischemic preconditioning neuroprotection stems from an epigenetic reprogramming of the brain to a phenotype of ischemic tolerance, which results ...
John W, Thompson, Kunjan R, Dave, Juan I, Young, Miguel A, Perez-Pinzon   +3 more
openaire   +2 more sources

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Ischemic postconditioning protects against ischemic brain injury by up-regulation of acid-sensing ion channel 2a

Neural Regeneration Research, 2016
Ischemic postconditioning renders brain tissue tolerant to brain ischemia, thereby alleviating ischemic brain injury. However, the exact mechanism of action is still unclear.
Wang-sheng Duanmu, Liu Cao, Jing-yu Chen, Hong-fei Ge, Rong Hu, Hua Feng   +5 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Acupuncture and neuroregeneration in ischemic stroke

Neural Regeneration Research, 2018
Acupuncture is potentially beneficial for post-stroke rehabilitation and is considered a promising preventive strategy for stroke. Electroacupuncture pretreatment or treatment after ischemic stroke by using appropriate electroacupuncture parameters ...
Qwang-Yuen Chang, Yi-Wen Lin, Ching-Liang Hsieh   +2 more
doaj   +1 more source

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source