Results 61 to 70 of about 63,266 (244)

Role of MicroRNAs in innate neuroprotection mechanisms due to preconditioning of the brain

Frontiers in Neuroscience, 2015
Insults to the brain that are sub-threshold for damage activate endogenous protective pathways, which can temporarily protect the brain against a subsequent harmful episode.
Eva Maria Jimenez-Mateos
doaj   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Mechanisms of Ischemic Induced Neuronal Death and Ischemic Tolerance [PDF]

, 2012
Stroke is the second leading cause of death and the primary cause of disability in humans. The phenomenon of ischemic tolerance perfectly describes the quote: “What does not kill you makes you stronger.’’ Ischemic preor postconditioning is actually the strongest known procedure to prevent or reverse delayed neuronal death.
Jan Lehotsky, Martina Pavlikova, Stanislav Straka, Maria Kovalska, Peter Kaplan, Zuzana Tatarkov   +5 more
openaire   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM+ Cholangiocyte Subcluster via Hypoxia/TGF‐β‐CREM‐VIM Axis

Advanced Science, EarlyView.
Single‐cell RNA sequencing verified the presence of the VIM+ biliary epithelial cell (BEC) in the bile ducts of NAS patients. The hypoxia/TGF‐β‐CREM‐VIM axis mediated phenotypic switch toward VIM+ BEC is validated using a hypoxia/TGF‐β‐stimulated cellular model, a rat liver transplantation model, BEC‐specific Crem conditional knockout rats, and BEC ...
Zhaoyi Wu, Nengsheng Fu, Zhongxin Huang, Yu Mou, Ensi Ma, Xiaoshi Wang, Tian Dong, Yujun Zhang, Danqing Liu, Di Jiang, Jingya Kuang, Rui Liao, Yifeng Tao, Leida Zhang, Chengcheng Zhang   +14 more
wiley   +1 more source

Clinical study of abnormal glucose metabolism screening for acute ischemic cerebral apoplexy in patients

SRM Journal of Research in Dental Sciences, 2015
Ischemic stroke refers to a focal neurological deficit attributable to the conditions created by the occlusion of an intracranial artery. We investigated how screening for abnormal glucose metabolism in acute ischemic cerebral apoplexy inpatients might ...
Wen-Zhen He, Xian-Guang Chen, Wen-Jie Chen, Xiao-Ling Xu   +3 more
doaj   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

New Perfusion and Preservation Strategies for Donor Hearts

European Surgical Research
Background: Several systems for organ procurement and transportation are available in heart transplantation. Hypothermic storage of the cardioplegic heart has been the global standard since the 1980s and provides consistently reliable outcomes.
Vincent Hendrik Hettlich, Hug Aubin, Maximilian Scherner, Bedri Ramadani, Artur Lichtenberg, Udo Boeken   +5 more
doaj   +1 more source

Diagnostics of impaired carbon metabolism in patients with ischemic heart disease.

Medičnì Perspektivi, 2018
Aim of the study – to investigate the prevalence of earlier non-diagnosed type 2 diabetes mellitus and prediabetes using different diagnostic approaches in patients with angiographically confirmed ischemic heart disease. Materials and methods. We studied
G. B. Mankovsky
doaj   +1 more source