Results 41 to 50 of about 121,748 (297)

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Enhancement of Subcutaneous Islet Transplant Performance by Collagen 1 Gel

Cell Transplantation
Human islets can be transplanted into the portal vein for T1 diabetes, and a similar procedure is being used in a clinical trial for stem cell–derived beta-like cells.
Anna French, Jennifer Hollister-Lock, Brooke A. Sullivan, Eline Stas, Albert J. Hwa, Gordon C. Weir, Susan Bonner-Weir   +6 more
doaj   +1 more source

Pig islets xenotransplantation: recent progress and current perspectives

Frontiers in Surgery, 2014
Islet xenotransplantation is a prospective treatment to bridge the gap between available human cells and needs of patients with diabetes. Pig is the ideal candidate to obtain such available islet cells.
Haitao eZhu, Wanli eWang, Liang eYu, Bo eWang   +3 more
doaj   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Intrapancreatic Ganglia and Neural Regulation of Pancreatic Endocrine Secretion

Frontiers in Neuroscience, 2019
Extrapancreatic nerves project to pancreatic islets directly or converge onto intrapancreatic ganglia. Intrapancreatic ganglia constitute a complex information-processing center that contains various neurotransmitters and forms an endogenous neural ...
Wenjing Li, Guangjiao Yu, Yudan Liu, Lei Sha   +3 more
doaj   +1 more source

Islet Gene View - a tool to facilitate islet research [PDF]

SSRN Electronic Journal, 2018
AbstractChanges in the hormone-producing pancreatic islets are central culprits in type 2 diabetes (T2D) pathogenesis. Characterization of gene expression in islets how it is altered in T2D are therefore vital in understanding islet function and T2D pathogenesis. We leveraged RNA-sequencing and genome-wide genotyping in islets from 188 donors to create
Dina Mansour-Aly, Gad Hatem, Chandra, Emilia Ottosson-Laakso, Nils Wierup, Ola Hansson, Ola Hansson, Rashmi B. Prasad, Petter Storm, Emma Ahlqvist, Otonkoski T, Otonkoski T, Erik Renström, Olle Korsgren, Olle Korsgren, Hindrik Mulder, Leif Groop, Leif Groop, Hazem Ibrahim, Isabella Artner, Claes B. Wollheim, Claes B. Wollheim, Tiinamaija Tuomi, Olof Asplund, Ulrika Krus   +24 more
openaire   +3 more sources

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

Islet Lymphocytes Maintain a Stable Regulatory Phenotype Under Homeostatic Conditions and Metabolic Stress

Frontiers in Immunology, 2022
T cells and B cells have been identified in human and murine islets, but the phenotype and role of islet lymphocytes is unknown. Resident immune populations set the stage for responses to inflammation in the islets during homeostasis and diabetes.
Jennifer C. Whitesell, Jennifer C. Whitesell, Jennifer C. Whitesell, Robin S. Lindsay, Robin S. Lindsay, Jessica G. Olivas-Corral, Jessica G. Olivas-Corral, Seth F. Yannacone, Mary H. Schoenbach, Mary H. Schoenbach, Erin D. Lucas, Rachel S. Friedman, Rachel S. Friedman, Rachel S. Friedman   +13 more
doaj   +1 more source

A Novel Sprayable Fibrinogen/Glycosaminoglycans/Collagen‐Based Bioink for Skin Wound Healing Applied by a Handheld Dual‐Head Airbrush

Advanced Healthcare Materials, EarlyView.
A dual‐head airbrush‐based spraying device, combined with a fibrinogen bioink enriched with glycosaminoglycans and collagen, enables the delivery of biomaterials and cells to promote wound healing. This system demonstrates effective skin regeneration in vitro and in vivo, with comparable results to autografts.
Paula Pleguezuelos‐Beltrán, Daniel Nieto‐García, Carlos Chocarro‐Wrona, Juan de Vicente, Patricia Gálvez‐Martín, José Manuel Entrena, Elena López‐Ruiz, Juan Antonio Marchal   +7 more
wiley   +1 more source

Tear-fluid-derived biomarkers of ocular complications in diabetes: a systematic review and meta-analysis

BMC Medicine
Background Early identification and management of sight-threatening ocular complications of diabetes using imaging or molecular biomarkers could help prevent vision loss.
Mya Polkamp, Nhan H. T. Pham, Wilson K. M. Wong, Hrishikesh P. Hardikar, Pooja S. Kunte, Morven A. Cameron, Anandwardhan A. Hardikar, Mugdha V. Joglekar   +7 more
doaj   +1 more source