Results 41 to 50 of about 235,553 (209)

In Vivo Ca_V3 Channel Inhibition Promotes Maturation of Glucose-Dependent Ca²⁺ Signaling in Human iPSC-Islets

Biomedicines, 2023
CaV3 channels are ontogenetically downregulated with the maturation of certain electrically excitable cells, including pancreatic β cells. Abnormally exaggerated CaV3 channels drive the dedifferentiation of mature β cells. This led us to question whether
Kaixuan Zhao, Yue Shi, Jia Yu, Lina Yu, Martin Köhler, Amber Mael, Anthony Kolton, Thomas Joyce, Jon Odorico, Per-Olof Berggren, Shao-Nian Yang   +10 more
doaj   +1 more source

The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes

Nature Communications
Type 1 diabetes (T1D) risk has been associated with enteroviral infections, particularly coxsackieviruses B (CVB). Cellular host factors contributing to virus-induced islet autoimmunity remain unclear.
Shirin Geravandi, Huan Liu, Heena Pahwa, Murali Krishna Madduri, Farah Atawneh, Adib Miraki Feriz, Sahar Rafizadeh, Annabelle Elisabeth Kruf, Mona Khazaei, Pouria Bahrami, David Gotti, Mohamed Elawour, Ruth M. Elgamal, Ausilia Maria Grasso, David Bund, Blaz Lupse, Zahra Azizi, Omar Zabad, Karim Bouzakri, Marc Horwitz, Alberto Pugliese, Kathrin Maedler, Amin Ardestani   +22 more
doaj   +1 more source

β-Cell Death in Diabetes: Past Discoveries, Present Understanding, and Potential Future Advances

Metabolites, 2021
β-cell death is regarded as a major event driving loss of insulin secretion and hyperglycemia in both type 1 and type 2 diabetes mellitus. In this review, we explore past, present, and potential future advances in our understanding of the mechanisms that
Noyonika Mukherjee, Li Lin, Christopher J. Contreras, Andrew T. Templin   +3 more
doaj   +1 more source

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas [PDF]

, 2000
Differentiation of early gut endoderm cells into the endocrine cells forming the pancreatic islets of Langerhans depends on a cascade of gene activation events controlled by transcription factors including the basic helix-loop-helix (bHLH) proteins.
Anderson, David J., Conners, Jennifer R., German, Michael S., Johnson, Jeffrey D., Kalamaras, Julie, Lee, Jacqueline E., Scheel, David W., Schwitzgebel, Valérie M., Sussel, Lori   +8 more
core  

In Vivo Imaging of Transplanted Islets with ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 by Targeting GLP-1 Receptor [PDF]

, 2011
Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for in vivo pancreatic islet imaging.
Bading, James R., Colcher, David, Conti, Peter E., Fraser, Scott E., Ishiyama, Kohei, Kandeel, Fouad, Li, Lin, Li, Zibo, Nair, Indu, Shively, John E., Todorov, Ivan, Wu, Zhanhong   +11 more
core   +2 more sources

Tear-fluid-derived biomarkers of ocular complications in diabetes: a systematic review and meta-analysis

BMC Medicine
Background Early identification and management of sight-threatening ocular complications of diabetes using imaging or molecular biomarkers could help prevent vision loss.
Mya Polkamp, Nhan H. T. Pham, Wilson K. M. Wong, Hrishikesh P. Hardikar, Pooja S. Kunte, Morven A. Cameron, Anandwardhan A. Hardikar, Mugdha V. Joglekar   +7 more
doaj   +1 more source

The Diabetic Dog as a Translational Model for Human Islet Transplantation. [PDF]

, 2017
The dog model has served as the primary method for early development of many diabetes therapies, including pancreatic islet transplantation techniques and immunosuppressive protocols.
Adin, Christopher A, Gilor, Chen
core  

Cell Therapy for Type 1 Diabetes [PDF]

, 2014
Acknowledgements The work described in this review was supported by a grant from the MRC. K.R.M. is supported by a fellowship from the Scottish Translational Medicines and Therapeutics Initiative through the Wellcome Trust.Peer reviewedPublisher ...
Docherty, H. M., Docherty, K., Lima, M. J., Muir, K. R.   +3 more
core   +1 more source

Intrapancreatic Ganglia and Neural Regulation of Pancreatic Endocrine Secretion

Frontiers in Neuroscience, 2019
Extrapancreatic nerves project to pancreatic islets directly or converge onto intrapancreatic ganglia. Intrapancreatic ganglia constitute a complex information-processing center that contains various neurotransmitters and forms an endogenous neural ...
Wenjing Li, Guangjiao Yu, Yudan Liu, Lei Sha   +3 more
doaj   +1 more source

Enhancement of Subcutaneous Islet Transplant Performance by Collagen 1 Gel

Cell Transplantation
Human islets can be transplanted into the portal vein for T1 diabetes, and a similar procedure is being used in a clinical trial for stem cell–derived beta-like cells.
Anna French, Jennifer Hollister-Lock, Brooke A. Sullivan, Eline Stas, Albert J. Hwa, Gordon C. Weir, Susan Bonner-Weir   +6 more
doaj   +1 more source