Results 131 to 140 of about 10,923 (183)

Non-fibril form but not fibril form of human islet amyloid polypeptide 8-20 changes brain functions in mice. [PDF]

PLoS One
Suginoma H, Owada R, Katano-Toki A, Mori A, Fujioka J, Nakamura K.   +5 more
europepmc   +1 more source

XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation. [PDF]

Genes Dis
Zhang Y, Lin S, Yao J, Cai W, Chen H, Aierken A, Wang Z, Song W.   +7 more
europepmc   +1 more source

The Inhibition Effect of Epigallocatechin-3-Gallate on the Co-Aggregation of Amyloid-β and Human Islet Amyloid Polypeptide Revealed by Replica Exchange Molecular Dynamics Simulations. [PDF]

Int J Mol Sci
Li X, Zhang Y, Yang Z, Zhang S, Zhang L.
europepmc   +1 more source

Islet amyloid polypeptide: demonstration of mRNA in human pancreatic islets by in situ hybridization in islets with and without amyloid deposits [PDF]

Diabetologia, 1993
Islet amyloid polypeptide which is normally coexpressed with insulin in beta cells, forms amyloid deposits especially in islets of Type 2 (non-insulin-dependent) diabetic subjects. Occurrence of islet amyloid is paradoxically associated with loss of islet amyloid polypeptide immunoreactivity in beta cells.
Per Westermark, Gunilla Westermark, Westermark P   +2 more
exaly   +3 more sources

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Islet Amyloid, Islet-Amyloid Polypeptide, and Diabetes Mellitus

New England Journal of Medicine, 1989
Islet-amyloid deposits, which are a common feature of Type II diabetes mellitus, are derived from the polymerization of a putative hormone identified as IAPP. IAPP is synthesized by normal islet beta cells and probably is cosecreted with insulin. Although the physiologic function of IAPP and its role in the pathogenesis of Type II diabetes mellitus are
Franklin H. Epstein, Kenneth H. Johnson, Timothy D. O'Brien, Christer Betsholtz, Per Westermark   +4 more
openaire   +2 more sources

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

Physiological Reviews, 2011
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both locally in the islets, where it inhibits insulin and glucagon secretion, and at distant targets.
Per, Westermark, Arne, Andersson, Gunilla T, Westermark   +2 more
openaire   +2 more sources

Islet Amyloid Polypeptide and Diabetes

Current Protein & Peptide Science, 2013
Islet amyloid polypeptide (IAPP, amylin) is a 37 amino acid residue hormone expressed mainly by pancreatic islet beta cells and to less extent by some gastrointestinal endocrine cells and by certain regions in central nervous system. In experimental systems a number of different effects have been ascribed to IAPP but the in vivo importance of many of ...
Gunilla T, Westermark, Per, Westermark
openaire   +2 more sources

Regulation of Islet Amyloid Polypeptide in Human Pancreatic Islets

Diabetes, 1993
This study investigated the effect of glucose on islet amyloid polypeptide secretion, content, and mRNA synthesis of human pancreatic islets. The release of islet amyloid polypeptide from fresh isolated islets in response to glucose was parallel to that of insulin.
A, Novials, Y, Sarri, R, Casamitjana, F, Rivera, R, Gomis   +4 more
openaire   +2 more sources

Transgenic Overproduction of Islet Amyloid Polypeptide (Amylin) is Not Sufficient for Islet Amyloid Formation

Hormone and Metabolic Research, 1997
Islet amyloid polypeptide forms islet amyloid deposits in non-insulin-dependent diabetes mellitus. We have generated transgenic mice which express human islet amyloid polypeptide in their pancreatic beta cells yet do not develop islet amyloid deposits despite producing levels of the amyloidogenic human peptide 2 - 3 fold higher than the native (mouse ...
C B, Verchere, D A, D'Alessio, S, Wang, S, Andrikopoulos, S E, Kahn   +4 more
openaire   +2 more sources

Amyloid in Human Islets of Langerhans: Immunologic Evidence That Islet Amyloid Polypeptide Is Modified in Amyloidogenesis

Pancreas, 2000
Amyloid derived from the beta-cell product islet amyloid polypeptide (IAPP) has been implicated for a beta-cell lesion in Type II diabetes mellitus. The pathogenesis of islet amyloid is poorly understood, and in addition to an amyloidogenic IAPP molecule and possibly increased concentration of IAPP, other unknown factors seem to be included.
Z, Ma, P, Westermark, G T, Westermark
openaire   +2 more sources