Results 141 to 150 of about 10,923 (183)

Renal Elimination of Islet Amyloid Polypeptide

Biochemical and Biophysical Research Communications, 1997
Six healthy volunteers showed significantly higher plasma islet amyloid polypeptide levels following an oral glucose tolerance test compared to fasting levels. The urine IAPP concentration before and after the OGTT was comparable to that in plasma. Reverse phase HPLC and radioimmunoassay analysis of urine samples revealed a single IAPP-immunoreactive ...
A, Leckström, K, Björklund, J, Permert, R, Larsson, P, Westermark   +4 more
openaire   +2 more sources

Islet Amyloid Polypeptide: Synthetic Peptides for Study of the Pathogenesis of Islet Amyloid

1991
Studies have indicated that the 20-29 segment of islet amyloid polypeptide (IAPP) determines the fibril formation. Variations between species in this region explain why only some species develop islet amyloid. This assumption is strongly supported by our study where we have used synthetic peptides in an fibril formation test system.
Per Westermark, Kenneth H. Johnson, Ulla Engström, Gunilla T. Westermark, Hel.lena Dominguez, Lars Christmansson, Christer Betsholtz   +6 more
openaire   +1 more source

Simulations of cross-amyloid aggregation of amyloid-β and islet amyloid polypeptide fragments

Biophysical Journal, 2022
Amyloid-β (Aβ) and islet amyloid polypeptide (IAPP) are small peptides, classified as amyloids, that have the potential to self-assemble and form cytotoxic species, such as small soluble oligomers and large insoluble fibrils. The formation of Aβ aggregates facilitates the progression of Alzheimer's disease (AD), while IAPP aggregates induce pancreatic ...
Grant E, Kawecki, Kelsie M, King, Nicholas A, Cramer, David R, Bevan, Anne M, Brown   +4 more
openaire   +2 more sources

Molecular biology of islet amyloid polypeptide

Diabetes Research and Clinical Practice, 1992
We investigated the relationship between non-insulin-dependent diabetes mellitus (NIDDM) and islet amyloid polypeptide (IAPP) gene by restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR)-direct sequencing analysis. Endonuclease BglII and/or PvuII RFLP analysis revealed no positive correlation of IAPP gene with NIDDM.
M, Nishi, T, Sanke, S, Ohagi, K, Ekawa, H, Wakasaki, K, Nanjo, G I, Bell, D F, Steiner   +7 more
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Islet amyloid polypeptide (IAPP) gene analysis in a Japanese diabetic with marked islet amyloid deposition

Diabetes Research and Clinical Practice, 1992
Islet amyloid polypeptide (IAPP) is a major constituent of pancreatic amyloid deposits in many patients with non-insulin-dependent diabetes mellitus (NIDDM). We analyzed the IAPP gene in a Japanese diabetic with marked islet amyloid deposition. Pancreatic specimens were obtained from an 87-year-old NIDDM patient who had had diabetes for 37 years.
Hiroshi Kajio, Tetsuro Kobayashi, Mitsuru Hara, Koji Nakanishi, Tadao Sugimoto, Toshio Murase, Yasuo Akanuma, Kinori Kosaka, Yoshikazu Shibasaki, Masato Kasuga, Nobuhiro Yamada, Yoshio Yazaki   +11 more
openaire   +2 more sources

Islet amyloid polypeptide (IAPP) and pancreatic islet amyloid deposition in diabetic and non-diabetic patients

Diabetes Research and Clinical Practice, 1992
Twenty pancreata of non-diabetic patients and 17 pancreata of diabetic patients, including two patients with insulin-dependent diabetes mellitus, were immunohistochemically studied using antiserum against human islet amyloid polypeptide (IAPP). The islet beta cells in non-diabetic patients were immunoreactive for both IAPP and insulin.
R, Narita, H, Toshimori, M, Nakazato, T, Kuribayashi, T, Toshimori, K, Kawabata, K, Takahashi, S, Masukura   +7 more
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Amyloid in the pancreatic islets of the cougar (Felis concolor) is derived from islet amyloid polypeptide (IAPP)

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1991
1. Islet amyloid isolated from the pancreas of a 20-year-old cougar (Felis concolor) was dissolved and purified by gel permeation and reversed phase HPLC for amino acid sequence analysis. 2. N-Terminal amino acid sequence analysis of the purified protein revealed a primary structure (positions 1-28) identical to islet amyloid polypeptide (IAPP) from ...
K H, Johnson, C, Wernstedt, T D, O'Brien, P, Westermark   +3 more
openaire   +2 more sources

Influence of islet amyloid polypeptide and the 8-37 fragment of islet amyloid polypeptide on insulin release from perifused rat islets

Diabetes, 1993
IAPP, or amylin, is a 37-amino acid peptide that is co-secreted with insulin from the pancreatic β-cells. We have determined the effects of IAPP and the antagonist 8–37 fragment of IAPP on the secretion of insulin from isolated rat islets studied in a perifusion system. Insulin secretion was stimulated by 8 mM glucose and 0.2 μM carbachol. IAPP at 10−7
Z L, Wang, W M, Bennet, M A, Ghatei, P G, Byfield, D M, Smith, S R, Bloom   +5 more
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Amyloidogenicity and cytotoxicity of islet amyloid polypeptide

Biopolymers, 2001
Insoluble amyloid formation by islet amyloid polypeptide (IAPP) in the islets of Langerhans of the pancreas is a major pathophysiological feature of noninsulin dependent diabetes mellitus (NIDDM) or type II diabetes. Because in vivo formed amyloid colocalizes with areas of cell degeneration and IAPP amyloid aggregates are cytotoxic per se, the process ...
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Islet Amyloid and Type 2 Diabetes Mellitus

New England Journal of Medicine, 2000
Almost a century ago, in 1901, Eugene L. Opie described “hyaline degeneration of the islands of Langerhans” in the pancreas of patients with hyperglycemia (Figure 1).1 A relation with diabetes mellitus was suggested, although at that time insulin had not yet been identified as an islet protein.
Höppener, J.W.M., Ahren, B., Lips, C.J.M.   +2 more
openaire   +3 more sources