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Oophorectomy promotes islet amyloid formation in human islet amyloid polypeptide transgenic mice.
Diabetes, 2001Islet amyloid polypeptide (IAPP) (amylin) is the unique peptide component of the amyloid deposits found at autopsy in >90% of subjects with type 2 diabetes (1). These amyloid deposits are thought to replace islet mass and to thereby contribute to the -cell dysfunction of the disease.
R L, Hull +5 more
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The role of SORLA in islet amyloid polypeptide transport and islet amyloid deposition
Der Sorting Related Receptor with A-type Repeats (SORLA) ist ein Sortierrezeptor, der von SORL1 kodiert wird, einem der Hauptrisikogene für die sporadische Alzheimer-Krankheit (AD). SORLA schützt vor Alzheimer, indem es die Akkumulation von Amyloid-beta-Peptiden in Amyloid-Plaque-Ablagerungen im Gehirn verhindert.openaire +1 more source
Formation of islet amyloid from islet amyloid polypeptide
Biochemical Society Transactions, 1993A, Clark, E J, de Koning, J F, Morris
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Pancreatic Islet Amyloid and Diabetes
2007Deposition of amyloid in pancreatic islets is a feature of type 2 diabetes in man but the causal factors are unknown. Progressive amyloidosis results in loss of insulin-producing cells and increased severity of disease. The fibril component is a 37-amino-acid peptide, islet amyloid polypeptide (IAPP; amylin), which is a normal cellular peptide ...
Anne Clark, Jenni Moffitt
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Amyloid of human islets of Langerhans
Virchows Archiv A Pathological Anatomy and Histology, 1977Isolated amyloid from the islets of Langerhans of patients with maturity onset diabetes mellitus was compared with amyloid fibrils from patients with different types of systemic amyloidosis. It was found that systemic amyloids had in common rigid and non-branching filaments with a width of about 75 A and that these filaments sometimes were attached ...
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AMYLOID OF HUMAN ISLETS OF LANGERHANS
Acta Pathologica Microbiologica Scandinavica Section C Immunology, 1975Islet amyloid concentrates containing a maximum of 50 per cent of amyloid fibrils as estimated by light microscopy were obtained from pancreases of patients with maturity onset diabetes mellitus. When centrifuged, the amyloid did not form a top layer as do most other amyloids, but was found in the bottom layer.
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Islet-amyloid polypeptide in human plasma
The Lancet, 1990Van Jaarsveld, B. C. +5 more
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Islet amyloid toxicity: From genesis to counteracting mechanisms
Journal of Cellular Physiology, 2022Renato Chaves Souto Branco +2 more
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