The Cells of the Islets of Langerhans [PDF]
Journal of Clinical Medicine, 2018 Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A number of new studies have pointed to the potential for conversion of non-β islet cells in to insulin-producing β-cells to replenish β-cell mass as a means to treat diabetes.
Da Silva Xavier G.
openaire +6 more sources
Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice [PDF]
, 2013 Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing beta-cells in the pancreas. Recruitment of inflammatory cells is prerequisite to beta-cell-injury.
Aurrand-Lions, Michel +10 more
core +8 more sources
Are physiological oscillations physiological?
The Journal of Physiology, EarlyView., 2023 Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley +1 more source
Macrophages in endocrine glands, with emphasis on pancreatic islets [PDF]
, 2016 We review here the macrophages found in endocrine tissues, placing emphasis on those residing in the islets of Langerhans of the pancreas. The islets represent the endocrine organ where macrophages have been examined in great detail and where our own ...
Unanue, Emil R
core +2 more sources
Lymphangiogenesis and angiogenesis during human fetal pancreas development [PDF]
, 2014 Background: The complex endocrine and exocrine functionality of the human pancreas depends on an efficient fluid transport through the blood and the lymphatic vascular systems. The lymphatic vasculature has key roles in the physiology of the pancreas and
Carlotti, Françoise +6 more
core +1 more source
Islet isolation assessment in man and large animals [PDF]
, 1990 Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R +25 more
core +1 more source
Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice [PDF]
, 2017 Significance Our studies indicate that the resident macrophages of the pancreatic islets of Langerhans have a seminal role in the initiation and progression of autoimmune diabetes in NOD mice.
Carrero, Javier A. +7 more
core +2 more sources
Islets of Langerhans Are Protected from Inflammatory Cell Recruitment during Reperfusion of Rat Pancreas Grafts [PDF]
, 2010 Background: Ischemia/reperfusion (I/R) injury plays a pivotal role in the development of graft pancreatitis, with ischemia time representing one of its crucial factors.
Eichhorn, M. E. +6 more
core +1 more source
A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of Langerhans [PDF]
, 2008 Background: The extracellular calcium-sensing receptor (CaR) is expressed in many tissues that are not associated with Ca2+ homeostasis, including the endocrine cells in pancreatic islets of Langerhans.
Burns, Christopher J. +4 more
core +1 more source
The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro [PDF]
, 2016 Aims: Diet-derived short chain fatty acids (SCFAs) improve glucose homeostasis in vivo, but the role of individual SCFAs and their mechanisms of action have not been defined.
Bewick, Gavin +14 more
core +4 more sources