Results 61 to 70 of about 32,122 (266)

Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans

Frontiers in Genetics, 2014
Type-2 diabetes (T2D) is a complex disease characterized by insulin resistance in target tissues and impaired insulin release from pancreatic beta cells. As central tissue of glucose homeostasis, the pancreatic islet continues to be an important focus of
J. Esguerra, L. Eliasson
semanticscholar   +1 more source

Engineering Marker‐Free Lettuce Chloroplast Genome to Express Functional Glucagon‐Like Peptide‐1 Receptor Agonists Exenatide and Lixisenatide

Plant Biotechnology Journal, EarlyView.
Engineering of marker‐free lettuce chloroplast genome to express CTB‐Exenatide and CTB‐Lixisenatide for oral delivery. Upper panel: Chemically synthesised exenatide or lixisenatide require expensive production, purification, refrigeration and invasive delivery methods.
Rahul Singh, Henry Daniell
wiley   +1 more source

Pancreatic islet (of Langerhans) revisited.

Histology and histopathology, 2019
One hundred and fifty years ago, Paul Langerhans described what would come to be known as pancreatic 'islet of Langerhans'. Since then, we have accumulated knowledge about the pancreatic islet, the cells that exist there and the hormones secreted by these cells.
openaire   +3 more sources

Epidemiology and Clinical Impact of Confirmed Respiratory Viral Infections in Solid Organ Transplant Recipients

Transplant Infectious Disease, EarlyView.
ABSTRACT Background Respiratory viral infections (RVIs) can have distinct clinical presentations and outcomes in non‐lung solid organ transplant (SOT) recipients compared to non‐transplant and lung transplant patients. Understanding their impact is crucial for improving patient care and outcomes.
Manon L. M. Prins, Ernst D. van Dokkum, Aiko P. J. de Vries, Maarten E. Tushuizen, Danny van der Helm, Edwin M. Spithoven, Irene M. van der Meer, Eduard M. Scholten, Albert M. Vollaard, Saskia le Cessie, Leo G. Visser, Geert H. Groeneveld   +11 more
wiley   +1 more source

In Vivo Imaging of Transplanted Pancreatic Islets

Frontiers in Endocrinology, 2018
The beta-cells in the islets of Langerhans in the pancreas secrete insulin and play an important role in glucose homeostasis. Diabetes, characterized by hyperglycemia, results from an absolute or a relative deficiency of the pancreatic beta-cell mass ...
Donghee Kim, Hee-Sook Jun, Hee-Sook Jun, Hee-Sook Jun   +3 more
doaj   +1 more source

Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis

Nature Communications, 2022
How pancreatic islets of Langerhans are built during development is incompletely understood. Here the authors find that Synaptotagmin-13 mediates remodeling of cell-matrix adhesion to regulate endocrine cell egression and islet morphogenesis.
Mostafa Bakhti, Aimée Bastidas-Ponce, Sophie Tritschler, Oliver Czarnecki, Marta Tarquis-Medina, Eva Nedvedova, Jessica Jaki, Stefanie J. Willmann, Katharina Scheibner, Perla Cota, Ciro Salinno, Karsten Boldt, Nicola Horn, Marius Ueffing, Ingo Burtscher, Fabian J. Theis, Ünal Coskun, Heiko Lickert   +17 more
doaj   +1 more source

IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation

International Journal of Immunopathology and Pharmacology, 2018
Recent findings revealed that type 2 diabetes mellitus (T2D) is a chronic inflammatory disease and an islet amyloid polypeptide (IAPP)/amylin, is deposited within pancreatic islets.
Shinnosuke Morikawa, Naoe Kaneko, Chikara Okumura, Haruka Taguchi, M. Kurata, Toshihiro Yamamoto, H. Osawa, Ayaka Nakanishi, T. Zako, J. Masumoto   +9 more
semanticscholar   +1 more source

A Case of Pancreatic Neuroendocrine Tumor Growing Intraductal Extension toward the Main Pancreatic Duct Complicated by Thrombocytopenia: Diagnostic Challenges and Management Strategy

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT We present a rare and diagnostically challenging case of a pancreatic neuroendocrine tumor (pNET) with intraductal growth into the main pancreatic duct (MPD), complicated by severe thrombocytopenia due to myelodysplastic syndrome. A 37‐year‐old male presented with thrombocytopenia.
Koichi Soga, Kazuma Sakakibara, Yuki Soma, Manayu Shiina, Mayumi Yamaguchi, Masaru Kuwada, Ryosaku Shirahashi, Ikuhiro Kobori, Shinichi Ban, Masaya Tamano   +9 more
wiley   +1 more source

Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices

PLoS Comput. Biol., 2013
We propose a network representation of electrically coupled beta cells in islets of Langerhans. Beta cells are functionally connected on the basis of correlations between calcium dynamics of individual cells, obtained by means of confocal laser-scanning ...
A. Stožer, M. Gosak, J. Dolenšek, M. Perc, M. Marhl, M. Rupnik, D. Korosak   +6 more
semanticscholar   +1 more source

Severity of complications is associated with impaired health‐related quality of life in people with type 1 diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1201-1212, February 2026.
Abstract Aims Health‐related quality of life (HRQoL) assessment is increasingly integrated into type 1 diabetes (T1D) monitoring to promote a holistic approach. To investigate HRQoL in adults with T1D and to assess the impact of the severity of complications on HRQoL.
Sara Barraud, Gloria A. Aguayo, Emmanuel Cosson, Chloé Amouyal, Sylvie Feldman, Jean‐François Gautier, Patricia Vaduva, Samy Hadjadj, Hélène Hanaire, Laurence Kessler, Emmanuelle Lecornet‐Sokol, Pascale Massin, Louis Potier, Eric Renard, Yves Reznik, Agnès Sola, Anne Vambergue, Camille Vatier, Bruno Vergès, Jean‐Pierre Riveline, Guy Fagherazzi   +20 more
wiley   +1 more source