Results 81 to 90 of about 32,122 (266)

Therapeutic Potential of Holothuria leucospilota Extract in STZ‐Induced Diabetic Rats: Targeting Inflammation and Apoptosis at the Gene Expression Level

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Holothuria leucospilota n‐hexane extract shows antidiabetic, anti‐inflammatory, and anti‐apoptotic effects in STZ‐induced diabetic rats. The extract modulates key pathways in glucose metabolism, insulin secretion, inflammation, and apoptosis. Treatment significantly decreased glucose and amyloid beta levels, increased insulin, and improved glycemic ...
Niloufar Darbandi, Muhanad Yusif Al‐rikabi   +1 more
wiley   +1 more source

Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans

PLoS ONE, 2013
Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patients with type 1 diabetes. However, the suboptimal microenvironment for islets in the liver is likely to be involved in the progressive islet dysfunction ...
M. Buitinga, R. Truckenmüller, M. Engelse, L. Moroni, H. ten Hoopen, C. V. van Blitterswijk, E. D. de Koning, A. V. van Apeldoorn, M. Karperien   +8 more
semanticscholar   +1 more source

Uncoupling Insulin Sensitivity From Longevity: A Sex‐Dependent Effect of Hepatic Glucagon Signaling

Aging Cell, Volume 25, Issue 1, January 2026.
Hepatic glucagon receptor knockout enhances metabolic health but shortens lifespan in female mice due to late‐life inflammation via NF‐κB and cGAS‐STING pathways, revealing a sexually dimorphic role in longevity despite metabolic benefits. ABSTRACT Glucagon, a key hormone in maintaining euglycemia during fasting, also exerts broad metabolic effects ...
Alexander Tate Lasher, Ben Heckman, Parth Sarker, Kaimao Liu, Liou Y. Sun   +4 more
wiley   +1 more source

Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β

PLoS ONE, 2012
Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. It alters pancreatic β-cell function and can be considered a risk factor for type 2 diabetes in rodents. Here we
S. Soriano, P. Alonso-Magdalena, M. García-Arévalo, A. Novials, S. Muhammed, A. Salehi, J. Gustafsson, I. Quesada, A. Nadal   +8 more
semanticscholar   +1 more source

Effect of Juvenile Obesity on the Islets of Langerhans in Rat and the Possibility of Recovery at Adulthood: A Histological and Immunohistochemical Study [PDF]

, 2020
Marwa A. Ibrahim, Khalid Ahmed Moustafa, Heba H. Elkaliny   +2 more
openalex   +1 more source

Maternal Autoimmune Disease and Childhood‐Onset Type 1 Diabetes: A Nationwide Population‐Based Nested Case‐Control Study

Pediatric Diabetes, Volume 2026, Issue 1, 2026.
Introduction Type 1 diabetes mellitus (T1DM) is an autoimmune disease that damages insulin‐producing pancreatic cells, often appearing in childhood. Global incidence is rising at 2%–3% yearly. Its exact cause is unclear. Prenatal exposures and maternal autoimmune disorders have been reported as potential risk factors.
Hsin-Chien Yen, Ching-Heng Lin, Ming-Chih Lin, Reem Al Khalifah   +3 more
wiley   +1 more source

Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

PLoS ONE, 2012
Background Type 2 diabetes is characterized by pancreatic β-cell dysfunction and is associated with low-grade inflammation. Recent observations suggest that the signalling cascade activated by lipopolysaccharides (LPS) binding to Toll-Like Receptor 4 ...
Julie Amyot, M. Semache, M. Ferdaoussi, G. Fontes, V. Poitout   +4 more
semanticscholar   +1 more source

Antidiabetic effects of fennel leaf aqueous extract in alloxan-induced diabetic rats

Journal of Pharmaceutical Health Care and Sciences
Background Diabetes Mellitus is a common chronic metabolic disease in the world population. There is evidences on the anti-hyperglycemic effects of different parts of fennel; however, the reports about antidiabetic activity of fennel leaves are not ...
Mahdi Noureddini, Maryam Akbari, Zeinab Vahidinia, Samaneh Sadat Alavi, Majid Nejati, Mohammad Ali Atlasi   +5 more
doaj   +1 more source

A web tool for easy and versatile analysis of human endocrine pancreas single‐cell RNAseq data

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1545-1549, February 2026.
Haya Benhayon, Xiaoyan Yi, Rachel Ben‐Haroush Schyr, Decio L. Eizirik, Danny Ben‐Zvi   +4 more
wiley   +1 more source

Prediction of Pancreatic Islet Yield After Pancreatectomy Using Optical Coherence Elastography

Diagnostics
Intraoperative assessment of pancreatic quality, followed by sampling for the potential isolation of Langerhans islets for subsequent autotransplantation, is currently a key component of post-total pancreatectomy diabetes mellitus treatment.
Ekaterina Gubarkova, Ekaterina Vasilchikova, Arseniy Potapov, Denis Kuchin, Polina Ermakova, Julia Tselousova, Anastasia Anina, Liya Lugovaya, Marina Sirotkina, Natalia Gladkova, Aleksandra Kashina, Vladimir Zagainov   +11 more
doaj   +1 more source