Results 1 to 10 of about 12,558 (256)
Strategies toward single-donor islets of Langerhans transplantation. [PDF]
Curr Opin Organ Transplant, 2011 The current review addresses a critical need in clinical islet transplantation, namely the routine transition from the requirement of two to four donors down to one donor per recipient. The ability to achieve single-donor islet transplantation will provide many more islet grafts for treatment of an ever-expanding patient base with type 1 diabetes (T1DM)
Shapiro AM.
europepmc +5 more sources
Microwell scaffolds for the extrahepatic transplantation of islets of Langerhans. [PDF]
PLoS ONE, 2013 Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patients with type 1 diabetes. However, the suboptimal microenvironment for islets in the liver is likely to be involved in the progressive islet dysfunction ...
Mijke Buitinga +8 more
doaj +8 more sources
From islet of Langerhans transplantation to the bioartificial pancreas
La Presse Médicale, 2022 Type 1 diabetes is a disease resulting from autoimmune destruction of the insulin-producing beta cells in the pancreas. When type 1 diabetes develops into severe secondary complications, in particular end-stage nephropathy, or life-threatening severe hypoglycemia, the best therapeutic approach is pancreas transplantation, or more recently ...
Thierry Berney +8 more
openaire +3 more sources
Transplantation or islets of Langerhans: new developments
Swiss Medical Weekly, 2001 The clinical results recently reported by the Edmonton group in recipients of allogeneic islet grafts, all of whom achieved at least temporary insulin independence, has rekindled interest in transplantation of islets of Langerhans as a means to cure diabetes.
A Caulfield +4 more
doaj +3 more sources
Biochemical and Biophysical Research Communications, 2003 Expression of immune modulating mediators in human Islets of Langerhans could have important implications for development of autoimmunity in type 1 diabetes and influence the outcome of clinical islet transplantation. Islets obtained from five donors were analyzed at various times after isolation using cDNA array technology.
Johansson, Ulrika +4 more
openaire +5 more sources
Transplantation of islets of Langerhans: new developments
Swiss medical weekly, 2001 The clinical results recently reported by the Edmonton group in recipients of allogeneic islet grafts, all of whom achieved at least temporary insulin independence, has rekindled interest in transplantation of islets of Langerhans as a means to cure diabetes.
Berney, Thierry +8 more
openaire +3 more sources
The pancreatic islet: a micro-organ in control [PDF]
CellR4, 2021 The islets of Langerhans constitute the endocrine pancreas which regulates blood glucose homeostasis and islet dysfunction results in diabetes. Each of the pancreatic islets constitutes an entire micro-organ with intricate cell to cell interactions and ...
M. Abdulreda, P. Berggren
doaj +1 more source
Perfusion-Based Recellularization of Rat Livers with Islets of Langerhans
Journal of Medical and Biological Engineering, 2022 Purpose Artificial organs might serve as alternative solutions for whole organ transplantation. Decellularization of a liver provides a non-immunogenic matrix with the advantage of three afferent systems, the portal vein, the hepatic artery and the bile ...
P. Demko +14 more
semanticscholar +2 more sources
Protecting islet functional viability using mesenchymal stromal cells
Stem Cells Translational Medicine, 2021 Islet transplantation is an emerging treatment for type 1 diabetes which offers the prospect of physiological control of blood glucose and reductions in acute hypoglycaemic episodes.
Ella L. Hubber +2 more
doaj +1 more source
Surface Coating of Islets of Langerhans by Activated Polyethylene Glycol [PDF]
علوم و تکنولوژی پلیمر, 2008 The final treatment for diabetes is transplantation of islets of Langerhans. One of the new proposed methods for immunological preservation of transplanted cells is coating of cell surface by polyethylene glycol.
S. Hashemi Najafabadi +3 more
doaj +1 more source