Results 1 to 10 of about 6,756 (199)

Transplantation or islets of Langerhans: new developments

Swiss Medical Weekly, 2001
The clinical results recently reported by the Edmonton group in recipients of allogeneic islet grafts, all of whom achieved at least temporary insulin independence, has rekindled interest in transplantation of islets of Langerhans as a means to cure diabetes.
Berney, Thierry, Buehler, Leo Hans, Caulfield, A, Oberholzer, José, Toso, Christian, Alejandro, R, Cooper, D K, Ricordi, C, Morel, Philippe   +8 more
doaj   +8 more sources

Strategies toward single-donor islets of Langerhans transplantation [PDF]

Current Opinion in Organ Transplantation, 2011
The current review addresses a critical need in clinical islet transplantation, namely the routine transition from the requirement of two to four donors down to one donor per recipient. The ability to achieve single-donor islet transplantation will provide many more islet grafts for treatment of an ever-expanding patient base with type 1 diabetes (T1DM)
Shapiro AM.
europepmc   +5 more sources

Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans [PDF]

PLoS ONE, 2013
Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patients with type 1 diabetes. However, the suboptimal microenvironment for islets in the liver is likely to be involved in the progressive islet dysfunction that is often observed post-transplantation.
Buitinga, M., Truckenmuller, R., Engelse, M.A., Moroni, L., Hoopen, H.W.M. ten, Blitterswijk, C.A. van, Koning, E.J.P. de, Apeldoorn, A.A. van, Karperien, M.   +8 more
doaj   +10 more sources

Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of Langerhans transplantation [PDF]

Biofabrication, 2015
In clinical islet transplantation, allogeneic islets of Langerhans are transplanted into the portal vein of patients with type 1 diabetes, enabling the restoration of normoglycemia. After intra-hepatic transplantation several factors are involved in the decay in islet mass and function mainly caused by an immediate blood mediated inflammatory response,
Marchioli, G., Gurp, L. van, Krieken, P.P. van, Stamatialis, D., Engelse, M., Blitterswijk, C.A. van, Karperien, M.B.J., Koning, E. de, Alblas, J., Moroni, L., Apeldoorn, A.A. van   +10 more
semanticscholar   +7 more sources

Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation

Biochemical and Biophysical Research Communications, 2003
Expression of immune modulating mediators in human Islets of Langerhans could have important implications for development of autoimmunity in type 1 diabetes and influence the outcome of clinical islet transplantation. Islets obtained from five donors were analyzed at various times after isolation using cDNA array technology.
Johansson, Ulrika, Olsson, Annika, Gabrielsson, Susanne, Nilsson, Bo, Korsgren, Olle   +4 more
semanticscholar   +8 more sources

Effects of energy dissipation rate on islets of Langerhans: Implications for isolation and transplantation [PDF]

Biotechnology and Bioengineering, 2009
AbstractAcute physical stresses can occur in the procurement and isolation process and potentially can contribute to islet death or malfunction upon transplantation. A contractional flow device, previously used to subject suspended cells to well‐defined hydrodynamic forces, has been modified and used to assess the vulnerability of porcine islets of ...
Klearchos K. Papas, Jeffrey J. Chalmers, Rubén Darío Godoy-Silva, Rustin M. Shenkman   +3 more
semanticscholar   +5 more sources

From islet of Langerhans transplantation to the bioartificial pancreas

La Presse Médicale, 2022
Type 1 diabetes is a disease resulting from autoimmune destruction of the insulin-producing beta cells in the pancreas. When type 1 diabetes develops into severe secondary complications, in particular end-stage nephropathy, or life-threatening severe hypoglycemia, the best therapeutic approach is pancreas transplantation, or more recently ...
Berney, Thierry, Wassmer, Charles H., Lebreton, Fanny, Bellofatto, Kevin, Fonseca, Laura Mar, Bignard, Juliette, Hanna, Reine, Peloso, Andrea, Berishvili, Ekaterine   +8 more
openaire   +4 more sources

A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation [PDF]

Transplant International, 2022
A global online survey was administered to 69 islet transplantation programs, covering 84 centers and 5 networks. The survey addressed questions on program organization and activity in the 2000–2020 period, including impact on activity of national health care coverage policies.
Berney, T, Andres, A, Bellin, MD, de Koning, EJP, Johnson, PRV, Kay, TWH, Lundgren, T, Rickels, MR, Scholz, H, Stock, PG, White, S, Aghayan, HR, Alejandro, R, Ricordi, C, Anazawa, T, Armanet, M, Cattan, P, Badet, L, Buron, F, Balamurugan, AN, Mokshagundam, SPL, Barton, FB, Benhamou, PY, Lablanche, S, Berishvili, E, Bosco, D, Pernin, N, Wassmer, CH, Bertuzzi, F, Borot, S, Bottino, R, Brendel, MD, Caicedo, LA, Echeverri, GJ, Casey, J, Choudhary, P, Coates, PT, Conget, I, Ventura-Aguiar, P, Cooper, M, Khan, KM, Debska-Slizien, A, Golebiewska, J, Desai, CS, Dominguez-Gil, B, Drago, J, Hyon, SH, Fedaruk, D, Goss, JA, Hering, BJ, Jung, HS, Kanak, MA, Kandeel, F, Kenmochi, T, Kessler, L, Munch, M, Keymeulen, B, Khambalia, H, Kim, JH, Korsgren, O, Kudva, YC, Stegall, MD, Labriola, L, Lee, EY, Yoon, KH, Lehmann, R, Ludwig, B, Lundren, T, Luo, X, Maffi, P, Piemonti, L, Markmann, J, Mattina, A, Meloche, M, Morgan, K, Naziruddin, B, Onaca, N, Odorico, JS, Paraskevas, S, Pattou, F, Vantyghem, MC, Romo, RM, Saudek, F, Shapiro, JAM, Shaw, J, Shimoda, M, Webster, A, Witkowski, P, Wojtusciszyn, A, Wszola, M   +89 more
openaire   +6 more sources

Encapsulation of Langerhans' islets: Microtechnological developments for transplantation

Engineering in Life Sciences, 2011
AbstractThere is an increasing trend to apply microsystems and microfluidics to solve medical and biomedical tasks. Microfluidic modules are used to modify and manipulate cells and cell clusters for therapeutic applications. Specifically, a method and technical system for encapsulation of Langerhans' islets as an option for the future treatment of ...
Friederike Ehrhart, Stefan Wiedemeier, Esther Mettler, Gunter Gastrock, Matthias M. Weber, Thomas Forst, Heiko Zimmermann, Josef Metze   +7 more
openaire   +2 more sources

Isolation, banking, encapsulation and transplantation of different types of Langerhans islets

Polish Archives of Internal Medicine, 2009
The discovery of a cure for diabetes is a dream of many medical researchers. The transplantation of Langerhans islets is a potential treatment of choice for patients with type 1 diabetes as a source of endogenous insulin for the recipient.The aim of the experiment was to transplant Langerhans islets without immunosuppression.
Joanna Kinasiewicz, Magdalena Antosiak-Iwańska, Marek Sabat, Andrzej Werynski, Ewa Godlewska, E. Sitarek   +5 more
openaire   +3 more sources