ECM Proteins Nidogen-1 and Decorin Restore Functionality of Human Islets of Langerhans upon Hypoxic Conditions. [PDF]
Adv Healthc MaterTransplantation of donor islets of Langerhans is a potential therapeutic approach for patients with diabetes mellitus; however, its success is limited by islet death and dysfunction during the initial hypoxic conditions at the transplantation site.
Jeyagaran A +11 more
europepmc +2 more sources
Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. [PDF]
, 2005 There are strong indications that only a small fraction of grafts successfully engraft in clinical islet transplantation. One explanation may be the instant blood-mediated inflammatory reaction (IBMIR) elicited by tissue factor, which is produced by the ...
H. Johansson +14 more
semanticscholar +2 more sources
Positron-emission tomography imaging of early events after transplantation of islets of Langerhans.
Transplantation, 2005 The aim of our study was to assess cell trafficking and early events after intraportal islet transplantation. Sprague-Dawley rat islets were incubated for various times, with various concentrations of 2-[F]fluoro-2deoxy-D-glucose (FDG), and in presence ...
C. Toso +10 more
semanticscholar +2 more sources
Reinnervation of Isolated Islets of Langerhans Transplanted beneath the Kidney Capsule in the Rat
Cell Transplantation, 1994 Neural regulation of islets of Langerhans mediates responses to stress and food ingestion. Transplantation of isolated islets offers hope to patients with insulin dependent diabetes mellitus but denervation of isolated islets may affect the capacity for appropriate metabolic control.
Teresa L. Krukoff +2 more
openaire +4 more sources
Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans [PDF]
Advanced Healthcare Materials, 2016 Giulia Marchioli +7 more
semanticscholar +2 more sources
Perfusion-Based Recellularization of Rat Livers with Islets of Langerhans
Journal of Medical and Biological Engineering, 2022 Purpose Artificial organs might serve as alternative solutions for whole organ transplantation. Decellularization of a liver provides a non-immunogenic matrix with the advantage of three afferent systems, the portal vein, the hepatic artery and the bile ...
P. Demko +14 more
semanticscholar +2 more sources
The pancreatic islet: a micro-organ in control [PDF]
CellR4, 2021 The islets of Langerhans constitute the endocrine pancreas which regulates blood glucose homeostasis and islet dysfunction results in diabetes. Each of the pancreatic islets constitutes an entire micro-organ with intricate cell to cell interactions and ...
M. Abdulreda, P. Berggren
doaj +1 more source
Stem cell research & therapeutics, 2022 Background Nowadays, diabetes mellitus is known as a silent killer because individual is not aware that he has the disease till the development of its complications.
A. Farid +4 more
semanticscholar +1 more source
Protecting islet functional viability using mesenchymal stromal cells
Stem Cells Translational Medicine, 2021 Islet transplantation is an emerging treatment for type 1 diabetes which offers the prospect of physiological control of blood glucose and reductions in acute hypoglycaemic episodes.
Ella L. Hubber +2 more
doaj +1 more source
Surface Coating of Islets of Langerhans by Activated Polyethylene Glycol [PDF]
علوم و تکنولوژی پلیمر, 2008 The final treatment for diabetes is transplantation of islets of Langerhans. One of the new proposed methods for immunological preservation of transplanted cells is coating of cell surface by polyethylene glycol.
S. Hashemi Najafabadi +3 more
doaj +1 more source