Results 21 to 30 of about 5,911 (222)

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-cadherin interaction and prolong function of transplanted encapsulated islets in mice

Stem Cell Research & Therapy, 2017
Background Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the function of islets.
Elisa Montanari, Raphael P. H. Meier, Redouan Mahou, Jörg D. Seebach, Christine Wandrey, Sandrine Gerber-Lemaire, Leo H. Buhler, Carmen Gonelle-Gispert   +7 more
doaj   +1 more source

Alotransplante de ilhotas de Langerhans no fígado de ratos submetidos a manipulação tímica com células não-parenquimatosas Allogenic islet transplantation on the rat liver after allogenic nonparenchymal cells injection in the thymus

Arquivos de Gastroenterologia, 2006
RACIONAL: A maior indicação do transplante de pâncreas ou de ilhotas de Langerhans é o diabetes mellitus do tipo I. O processo deve suprir as necessidades de insulina, mantendo os níveis glicêmicos dentro da normalidade OBJETIVOS: Estudar o ...
Eleazar Chaib, Apostolos Papalois, Ingrid G. M. Brons, Roy Y. Calne   +3 more
doaj   +1 more source

Entrapment of Cultured Pancreas Islets in Three-Dimensional Collagen Matrices

Cell Transplantation, 1992
In vitro culture of islets of Langerhans decreases their immunogenecity, presumably by eliminating passenger leukocytes and other Ia+ presenting cells within the islets.
Seh-Huang Chao, Madhusudan V. Peshwa, David E.R. Sutherland M.D., Ph.D., Wei-Shou Hu   +3 more
doaj   +1 more source

Islet Cell Transplantation: In Vivo and in Vitro Functional Assessment of Nonhuman Primate Pancreatic Islets

Cell Transplantation, 2000
Transplantation of pancreatic islets of Langerhans as a therapeutic approach for treatment of type I diabetes offers an alternative to subcutaneous insulin injections.
Alessandra Rammcoli, Nicola Cautero, Camillo Ricordi, Michele Masetti, Ruth D. Molano, Luca Inverardi, Rodolfo Alejandro, Norma S. Kenyon Ph.D.   +7 more
doaj   +1 more source

Stepwise Approach to Problematic Hypoglycemia in Korea: Educational, Technological, and Transplant Interventions [PDF]

Endocrinology and Metabolism, 2017
Impaired awareness of hypoglycemia has been found to be prevalent in 20% to 40% of people with type 1 diabetes. If a similar prevalence exists in Koreans with type 1 diabetes, at a minimum, thousands of people with type 1 diabetes suffer at least one ...
Sang-Man Jin
doaj   +1 more source

The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity

Frontiers in Endocrinology, 2021
The endocrine cells confined in the islets of Langerhans are responsible for the maintenance of blood glucose homeostasis. In particular, beta cells produce and secrete insulin, an essential hormone regulating glucose uptake and metabolism.
Erwin Ilegems, Per-Olof Berggren, Per-Olof Berggren, Per-Olof Berggren, Per-Olof Berggren, Per-Olof Berggren   +5 more
doaj   +1 more source

Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives

Clinical Medicine Insights: Endocrinology and Diabetes, 2019
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells located in the endocrine pancreas in areas known as islets of Langerhans. The current standard-of-care for T1D is exogenous insulin replacement therapy.
Varun Pathak, Nupur Madhur Pathak, Christina L O’Neill, Jasenka Guduric-Fuchs, Reinhold J Medina   +4 more
doaj   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Redox-Dependent Inflammation in Islet Transplantation Rejection

Frontiers in Endocrinology, 2018
Type 1 diabetes is an autoimmune disease that results in the progressive destruction of insulin-producing pancreatic β-cells inside the islets of Langerhans.
Jessie M. Barra, Hubert M. Tse
doaj   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source