Results 31 to 40 of about 6,756 (199)

Alotransplante de ilhotas de Langerhans no fígado de ratos submetidos a manipulação tímica com células não-parenquimatosas Allogenic islet transplantation on the rat liver after allogenic nonparenchymal cells injection in the thymus

Arquivos de Gastroenterologia, 2006
RACIONAL: A maior indicação do transplante de pâncreas ou de ilhotas de Langerhans é o diabetes mellitus do tipo I. O processo deve suprir as necessidades de insulina, mantendo os níveis glicêmicos dentro da normalidade OBJETIVOS: Estudar o ...
Eleazar Chaib, Apostolos Papalois, Ingrid G. M. Brons, Roy Y. Calne   +3 more
doaj   +1 more source

A High Cell-Bearing Capacity Multibore Hollow Fiber Device for Macroencapsulation of Islets of Langerhans.

Macromolecular Bioscience, 2020
Macroencapsulation of islets of Langerhans is a promising strategy for transplantation of insulin-producing cells in the absence of immunosuppression to treat type 1 diabetes.
K. Skrzypek, Milou Groot Nibbelink, J. Liefers-Visser, A. Smink, Eleftheria Stoimenou, M. Engelse, E. D. de Koning, M. Karperien, P. de Vos, A. V. van Apeldoorn, D. Stamatialis   +10 more
semanticscholar   +1 more source

Stepwise Approach to Problematic Hypoglycemia in Korea: Educational, Technological, and Transplant Interventions [PDF]

Endocrinology and Metabolism, 2017
Impaired awareness of hypoglycemia has been found to be prevalent in 20% to 40% of people with type 1 diabetes. If a similar prevalence exists in Koreans with type 1 diabetes, at a minimum, thousands of people with type 1 diabetes suffer at least one ...
Sang-Man Jin
doaj   +1 more source

Entrapment of Cultured Pancreas Islets in Three-Dimensional Collagen Matrices

Cell Transplantation, 1992
In vitro culture of islets of Langerhans decreases their immunogenecity, presumably by eliminating passenger leukocytes and other Ia+ presenting cells within the islets.
Seh-Huang Chao, Madhusudan V. Peshwa, David E.R. Sutherland M.D., Ph.D., Wei-Shou Hu   +3 more
doaj   +1 more source

Suppression of Fibrotic Reactions of Chitosan-Alginate Microcapsules Containing Porcine Islets by Dexamethasone Surface Coating [PDF]

Endocrinology and Metabolism, 2021
Background The microencapsulation is an ideal solution to overcome immune rejection without immunosuppressive treatment. Poor biocompatibility and small molecular antigens secreted from encapsulated islets induce fibrosis infiltration.
Min Jung Kim, Heon-Seok Park, Ji-Won Kim, Eun-Young Lee, Marie Rhee, Young-Hye You, Gilson Khang, Chung-Gyu Park, Kun-Ho Yoon   +8 more
doaj   +1 more source

Islet Cell Transplantation: In Vivo and in Vitro Functional Assessment of Nonhuman Primate Pancreatic Islets

Cell Transplantation, 2000
Transplantation of pancreatic islets of Langerhans as a therapeutic approach for treatment of type I diabetes offers an alternative to subcutaneous insulin injections.
Alessandra Rammcoli, Nicola Cautero, Camillo Ricordi, Michele Masetti, Ruth D. Molano, Luca Inverardi, Rodolfo Alejandro, Norma S. Kenyon Ph.D.   +7 more
doaj   +1 more source

The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity

Frontiers in Endocrinology, 2021
The endocrine cells confined in the islets of Langerhans are responsible for the maintenance of blood glucose homeostasis. In particular, beta cells produce and secrete insulin, an essential hormone regulating glucose uptake and metabolism.
Erwin Ilegems, Per-Olof Berggren, Per-Olof Berggren, Per-Olof Berggren, Per-Olof Berggren, Per-Olof Berggren   +5 more
doaj   +1 more source

Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives

Clinical Medicine Insights: Endocrinology and Diabetes, 2019
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells located in the endocrine pancreas in areas known as islets of Langerhans. The current standard-of-care for T1D is exogenous insulin replacement therapy.
Varun Pathak, Nupur Madhur Pathak, Christina L O’Neill, Jasenka Guduric-Fuchs, Reinhold J Medina   +4 more
doaj   +1 more source

Redox-Dependent Inflammation in Islet Transplantation Rejection

Frontiers in Endocrinology, 2018
Type 1 diabetes is an autoimmune disease that results in the progressive destruction of insulin-producing pancreatic β-cells inside the islets of Langerhans.
Jessie M. Barra, Hubert M. Tse
doaj   +1 more source

Encapsulation of Islets in Rough Surface, Hydroxymethylated Polysulfone Capillaries Stimulates VEGF Release and Promotes Vascularization after Transplantation

Cell Transplantation, 2005
The transplantation of encapsulated islets of Langerhans is one approach to treat type 1 diabetes without the need of lifelong immunosuppression. Capillaries have been used for macroencapsulation because they have a favorable surface-to-volume ratio and ...
N. Lembert, J. Wesche, P. Petersen, M. Doser, P. Zschocke, H. D. Becker, H. P. T. Ammon   +6 more
doaj   +1 more source