Results 41 to 50 of about 12,558 (256)

Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets [PDF]

, 2018
BACKGROUND: Subcutaneous implantation of a macroencapsulated patch containing human allogenic islets has been successfully used to alleviate type 1 diabetes mellitus (T1DM) in a human recipient without the need for immunosuppression.
Crossan, Claire, Gianello, Pierre, Mourad, Nizar I., Scobie, Linda, Smith, Karen   +4 more
core   +1 more source

Reinnervation of Isolated Islets of Langerhans Transplanted beneath the Kidney Capsule in the Rat

Cell Transplantation, 1994
Neural regulation of islets of Langerhans mediates responses to stress and food ingestion. Transplantation of isolated islets offers hope to patients with insulin dependent diabetes mellitus but denervation of isolated islets may affect the capacity for ...
Andrew J. Portis, Ray V. Rajotte Dr., Teresa L. Krukoff   +2 more
doaj   +1 more source

Cell Therapy for Type 1 Diabetes [PDF]

, 2014
Acknowledgements The work described in this review was supported by a grant from the MRC. K.R.M. is supported by a fellowship from the Scottish Translational Medicines and Therapeutics Initiative through the Wellcome Trust.Peer reviewedPublisher ...
Docherty, H. M., Docherty, K., Lima, M. J., Muir, K. R.   +3 more
core   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Redox-Dependent Inflammation in Islet Transplantation Rejection

Frontiers in Endocrinology, 2018
Type 1 diabetes is an autoimmune disease that results in the progressive destruction of insulin-producing pancreatic β-cells inside the islets of Langerhans.
Jessie M. Barra, Hubert M. Tse
doaj   +1 more source

A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo [PDF]

, 2015
SCOPUS: ar.jinfo:eu-repo/semantics ...
Beyaert, Rudi, Cardozo, AK, Catrysse, Leen, Fukaya, M, Meyerovich, K, Sze, Mozes, van Loo, Geert   +6 more
core   +2 more sources

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Encapsulation of Islets in Rough Surface, Hydroxymethylated Polysulfone Capillaries Stimulates VEGF Release and Promotes Vascularization after Transplantation

Cell Transplantation, 2005
The transplantation of encapsulated islets of Langerhans is one approach to treat type 1 diabetes without the need of lifelong immunosuppression. Capillaries have been used for macroencapsulation because they have a favorable surface-to-volume ratio and ...
N. Lembert, J. Wesche, P. Petersen, M. Doser, P. Zschocke, H. D. Becker, H. P. T. Ammon   +6 more
doaj   +1 more source

ECM Proteins Nidogen‐1 and Decorin Restore Functionality of Human Islets of Langerhans upon Hypoxic Conditions

Advanced Healthcare Materials
Transplantation of donor islets of Langerhans is a potential therapeutic approach for patients with diabetes mellitus; however, its success is limited by islet death and dysfunction during the initial hypoxic conditions at the transplantation site.
Abiramy Jeyagaran, Max Urbanczyk, Daniel A Carvajal-Berrio, Teresa Baldissera, P. Kaiser, L. Kuhlburger, Stefan Czemmel, Sven Nahnsen, G. Duffy, S. Brucker, S. Layland, Katja Schenke‐Layland   +11 more
semanticscholar   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source