Results 41 to 50 of about 6,756 (199)

Large Mammalian Model for Extrahepatic Langerhans Transplantation for the Treatment of Type 1 Diabetes

, 2020
Beta-cell replacement therapy, by transplantation of isolated islets of Langerhans offers a physiologic alternative to subcutaneous insulin injections in treatment of treatment of type 1 diabetes.
G. Kenchadze
semanticscholar   +1 more source

Successful Suppression of the Early Rejection of Pig Islets in Monkeys

Cell Transplantation, 2000
Primary nonfunction (PNF) is seen very frequently after xenogeneic transplantation of islets of Langerhans. In a pig-to-rat model we recently observed that no PNF occurs when the islets are kept in culture at 37°C for 1–2 weeks prior to transplantation ...
Josephine K. R. A. Rijkelijkhuizen, Eelco Bouwman, Michel P. M. Van Der Burg, Jan Ringers, Miriam A. Ossevoort, Eva M. Kuhn, Pat Frost, Margreet Jonker   +7 more
doaj   +1 more source

Label-free detection of insulin and glucagon within human islets of Langerhans using Raman spectroscopy. [PDF]

PLoS ONE, 2013
Intrahepatic transplantation of donor islets of Langerhans is a promising therapy for patients with type 1 diabetes. It is of critical importance to accurately monitor islet quality before transplantation, which is currently done by standard histological
Janneke Hilderink, Cees Otto, Cees Slump, Aufried Lenferink, Marten Engelse, Clemens van Blitterswijk, Eelco de Koning, Marcel Karperien, Aart van Apeldoorn   +8 more
doaj   +1 more source

Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation

Journal of Translational Medicine, 2007
While insulin replacement remains the cornerstone treatment for type I diabetes mellitus (T1DM), the transplantation of pancreatic islets of Langerhans has the potential to become an important alternative.
Li Xin, Harlan David M, Liu Eric, Wang Ena, Jin Ping, Ren Jiaqiang, Stroncek David F   +6 more
doaj   +1 more source

Mesenchymal stromal cells support endothelial cell interactions in an intramuscular islet transplantation model [PDF]

Regenerative Medicine Research, 2015
Background: Mesenchymal stromal cells (MSC) have been under investigation for a number of therapies and have lately been in focus as immunosuppressive actors in the field of transplantation.
Fransson Moa, Brännström Johan, Duprez Ida, Essand Magnus, Le Blanc Katarina, Korsgren Olle, Magnusson Peetra U.   +6 more
doaj   +1 more source

A Practical Guide to Rodent Islet Isolation and Assessment

Biological Procedures Online, 2009
Pancreatic islets of Langerhans secrete hormones that are vital to the regulation of blood glucose and are, therefore, a key focus of diabetes research. Purifying viable and functional islets from the pancreas for study is an intricate process.
Carter Jeffrey, Dula Stacey, Corbin Kathryn, Wu Runpei, Nunemaker Craig   +4 more
doaj   +3 more sources

Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of ob/ob Mice

Metabolites, 2021
The pancreatic islets of Langerhans consist of endocrine cells that secrete peptide hormones into the blood circulation in response to metabolic stimuli. When transplanted into the anterior chamber of the eye (ACE), pancreatic islets engraft and maintain
Barbara Leibiger, Tilo Moede, Ismael Valladolid-Acebes, Meike Paschen, Montse Visa, Ingo B. Leibiger, Per-Olof Berggren   +6 more
doaj   +1 more source

Human islet xenotransplantation in rodents: A literature review of experimental model trends

Clinics
Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low
Leandro Ryuchi Iuamoto, André Silva Franco, Fábio Yuji Suguita, Felipe Futema Essu, Lucas Torres Oliveira, Juliana Mika Kato, Matheus Belloni Torsani, Alberto Meyer, Wellington Andraus, Eleazar Chaib, Luiz Augusto Carneiro D’Albuquerque   +10 more
doaj   +1 more source

IDENTIFICATION OF ISLET CAPACITY IN DONOR’S PANCREAS USING IMMUNOMORPHOLOGICAL ANALYSIS

Вестник трансплантологии и искусственных органов, 2016
The aim of the work was detailed morphological investigations of donor pancreas (DP) for the study of possibilities of maximal selection of islet tissue suitable for transplantation to a patient of diabetes mellitus type 1.Materials and methods.
N. N. Skaletskiy, L. A. Kirsanova, G. N. Bubentsova, N. V. Baranova, G. N. Skaletskaya, V. I. Sevastianov   +5 more
doaj   +1 more source

A Practical Guide to Rodent Islet Isolation and Assessment Revisited

Biological Procedures Online, 2021
Insufficient insulin secretion is a key component of both type 1 and type 2 diabetes. Since insulin is released by the islets of Langerhans, obtaining viable and functional islets is critical for research and transplantation.
Kathryn L. Corbin, Hannah L. West, Samantha Brodsky, Nicholas B. Whitticar, William J. Koch, Craig S. Nunemaker   +5 more
doaj   +1 more source