Journal of Transplantation, 2011 Transplantation therapy for diabetes is limited by unavailability of donor organs and outcomes complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems.
Marc R. Hammerman
doaj +1 more source
Stem Cell Research & Therapy, 2019 Background Islets of Langerhans transplantation is a promising therapy for type 1 diabetes mellitus, but this technique is compromised by transplantation stresses including inflammation.
Camille Laporte +12 more
doaj +1 more source
Human islet transplantation - state of the art [PDF]
Einstein (São Paulo), 2005 Currently, only vascularized pancreas transplantation can reestablishlong-term normoglycemia but the scenario has beenassociated with significant morbidity and mortality.
Eleazar Chaib +4 more
doaj
The Islet Size to Oxygen Consumption Ratio Reliably Predicts Reversal of Diabetes Posttransplant
Cell Transplantation, 2012 β-Cell replacement therapy by either whole-organ pancreas or islets of Langerhans transplantation can restore carbohydrate control to diabetic patients and reduces complications associated with the disease.
Andrew R. Pepper +6 more
doaj +1 more source
Intraocular in vivo imaging of pancreatic islet cell physiology/pathology
Molecular Metabolism, 2017 Background: Diabetes mellitus has reached epidemic proportions and requires new strategies for treatment. Unfortunately, the efficacy of treatment regimens on maintaining/re-gaining functional beta cell mass can, at the present, only be determined ...
Ingo B. Leibiger, Per-Olof Berggren
doaj +1 more source
Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
Journal of Transplantation, 2011 Lack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of ...
Marc R. Hammerman
doaj +1 more source
Follow-up Study of the Revascularization Process of Purified Rat Islet Beta-Cell Grafts
Cell Transplantation, 1997 The revascularization of islets of Langerhans transplanted in heterotopic sites like the liver by portal vein embolization or the renal subcapsular space is a major process necessary for the viability of grafted cells.
José F. Mendola +6 more
doaj +1 more source
Clinical Trial Protocol for Porcine Islet Xenotransplantation in South Korea [PDF]
Diabetes & Metabolism JournalBackground Islet transplantation holds promise for treating selected type 1 diabetes mellitus patients, yet the scarcity of human donor organs impedes widespread adoption.
Byung-Joon Kim +18 more
doaj +1 more source
Thrombomodulin expression on Langerhans' islet: can endogenous ‘anticoagulant on demand’ overcome detrimental thrombotic complications in clinical islet transplantation? [PDF]
, 2004 S. Iino +4 more
openalex +1 more source
Absence of CSF-1-Dependent Macrophages Does Not Improve Function of Transplanted Islets of Langerhans [PDF]
, 2001 Thierry Berney +6 more
openalex +1 more source