Results 51 to 60 of about 12,558 (256)

Successful Suppression of the Early Rejection of Pig Islets in Monkeys

Cell Transplantation, 2000
Primary nonfunction (PNF) is seen very frequently after xenogeneic transplantation of islets of Langerhans. In a pig-to-rat model we recently observed that no PNF occurs when the islets are kept in culture at 37°C for 1–2 weeks prior to transplantation ...
Josephine K. R. A. Rijkelijkhuizen, Eelco Bouwman, Michel P. M. Van Der Burg, Jan Ringers, Miriam A. Ossevoort, Eva M. Kuhn, Pat Frost, Margreet Jonker   +7 more
doaj   +1 more source

Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation

Journal of Translational Medicine, 2007
While insulin replacement remains the cornerstone treatment for type I diabetes mellitus (T1DM), the transplantation of pancreatic islets of Langerhans has the potential to become an important alternative.
Li Xin, Harlan David M, Liu Eric, Wang Ena, Jin Ping, Ren Jiaqiang, Stroncek David F   +6 more
doaj   +1 more source

Engineering an endocrine Neo-Pancreas by repopulation of a decellularized rat pancreas with islets of Langerhans [PDF]

, 2017
Decellularization of pancreata and repopulation of these non-immunogenic matrices with islets and endothelial cells could provide transplantable, endocrine Neo- Pancreata.
Andreou, A., Everwien, H., Gassner, J., Geisel, D., Haep, N., Hillebrandt, K.-H., Kluge, M., Lippert, S., Napierala, H., Noesser, M., Polenz, D., Pratschke, J., Raschzok, N., Sauer, I. M., Seiffert, N., Selke, A. Reutzel, Struecker, B., Tang, P., Teegen, E., Tintemann, M.   +19 more
core   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Label-free detection of insulin and glucagon within human islets of Langerhans using Raman spectroscopy. [PDF]

PLoS ONE, 2013
Intrahepatic transplantation of donor islets of Langerhans is a promising therapy for patients with type 1 diabetes. It is of critical importance to accurately monitor islet quality before transplantation, which is currently done by standard histological
Janneke Hilderink, Cees Otto, Cees Slump, Aufried Lenferink, Marten Engelse, Clemens van Blitterswijk, Eelco de Koning, Marcel Karperien, Aart van Apeldoorn   +8 more
doaj   +1 more source

Enumeration of islets by nuclei counting and light microscopic analysis [PDF]

, 2010
Author Manuscript 2011 May 1.Islet enumeration in impure preparations by conventional dithizone staining and visual counting is inaccurate and operator dependent.
AA Lin, Abdulkadir Omer, AC Wardlaw, AMJ Shapiro, AMJ Shapiro, Anna Pisania, AU Parman, B Hirshberg, B Keymeulen, BJ Hering, C Ricordi, C Ricordi, C Ricordi, C Ricordi, CA Fraker, CE Sever, Clark K Colton, CN Street, Daryl E Powers, DG Pipeleers, DG Pipeleers, DJ Weber, DW Scharp, E Linetsky, ER Weibel, GC Weir, Gordon C Weir, J Beckmann, J Dolezel, JJ O'Neil, JP Stegemann, JP Stegemann, JP Stegemann, KK Papas, KK Papas, KK Sanford, Klearchos K Papas, L Churney, M Absher, M Asfari, M Goto, Michael J Rappel, MK Patterson, MP Van der Burg, N Lembert, P Girman, PE Lacy, R Lehmann, RA Knazek, RG Bretzel, RI Freshney, S Efrat, Susan Bonner-Weir, TJ Fetterhoff, ZA Latif   +54 more
core   +1 more source

Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips

Advanced Biology, Volume 10, Issue 2, February 2026.
Buck and Bugter et al. explore the architectural diversity and physiological functions of human barrier systems and reveal how organ‐on‐chip platforms, particularly those integrating patient‐derived cells, are advancing barrier disease modeling. They highlight how emerging biological and technological advances can be used to bridge the gap between ...
Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler   +4 more
wiley   +1 more source

A Practical Guide to Rodent Islet Isolation and Assessment Revisited

Biological Procedures Online, 2021
Insufficient insulin secretion is a key component of both type 1 and type 2 diabetes. Since insulin is released by the islets of Langerhans, obtaining viable and functional islets is critical for research and transplantation.
Kathryn L. Corbin, Hannah L. West, Samantha Brodsky, Nicholas B. Whitticar, William J. Koch, Craig S. Nunemaker   +5 more
doaj   +1 more source

Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant. [PDF]

, 2017
The advent of large-scale in vitro differentiation of human stem cell-derived insulin-producing cells (SCIPC) has brought us closer to treating diabetes using stem cell technology. However, decades of experiences from islet transplantation show that
Faleo, Gaetano, Freise, Jonathan E, Hebrok, Matthias, Nair, Gopika G, Nguyen, Vinh, Parent, Audrey V, Russ, Holger A, Szot, Gregory L, Tang, Qizhi, Villanueva, Karina E, Wisel, Steven   +10 more
core   +2 more sources

Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine

MedComm, Volume 7, Issue 2, February 2026.
Schematic illustration showing multifunctional hydrogels in the application of tissue engineering and regenerative medicine. ABSTRACT Hydrogels, with excellent hydrophilicity and high‐water content, have emerged as highly versatile biomaterials for tissue engineering and regenerative medicine.
Jieran Lyu, Xuemiao Liu, Qiqi Yang, Yuchang Zhang, Xing Wang   +4 more
wiley   +1 more source