Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. [PDF]
, 2011 Label-free LC-MS/MS-based shot-gun proteomics was used to quantify the differential protein synthesis and metabolite profiling in order to assess metabolic changes during the development of citrus fruits.
Blumwald, Eduardo +8 more
core +3 more sources
Artificial intelligence-based locoregional markers of brain peritumoral microenvironment [PDF]
arXiv, 2022 In malignant primary brain tumors, cancer cells infiltrate into the peritumoral brain structures which results in inevitable recurrence. Quantitative assessment of infiltrative heterogeneity in the peritumoral region, the area where biopsy or resection can be hazardous, is important for clinical decision making.
arxiv
Changes in protein expression in two cholangiocarcinoma cell lines undergoing formation of multicellular tumor spheroids In vitro [PDF]
, 2015 Epithelial-to-Mesenchymal Transition (EMT) is relevant in malignant growth and frequently correlates with worsening disease progression due to its implications in metastases and re- sistance to therapeutic interventions.
Agostinelli, Enzo +15 more
core +2 more sources
Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
Journal of Clinical Investigation, 2017 Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 are among the first genetic alterations observed during the development of lower-grade glioma (LGG).
G. Kohanbash +14 more
semanticscholar +1 more source
CLINICAL STUDIES ON ISOCITRIC DEHYDROGENASE
Nihon Naika Gakkai Zasshi, 1963 イソクエン酸脱水素酵素(ICD)はTPNを補酵素とする脱水素酵素であり肝細胞中の糸粒体に主として認められているが,著者は正常者および各種疾患々者血清中の本酵素活性値を測定した.またこれと並行してトランスアミナーゼ活性値,乳酸脱水素酵素活性値を測定し,各酵素の変動および相関につき觀察した.イソクエン酸脱水素酵素は他の酵素に比べ,肝疾患に特異的であり,特に急性肝炎黄疸前期に著明な活性値上昇を来たし,また肝性昏睡時に中等度の活性値の上昇を来たすことを認めた.慢性肝炎,肝硬変では正常乃至は正常値を多少上廻る活性値を示したが,閉塞性黄疸では一般に上昇は認められず,二次的に肝細胞障害を来たした例には活性値上昇が認められた.その他の疾患ではICD値は正常値を示した ...
openaire +4 more sources
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes
The Scientific World Journal, 2014 Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε ...
Martin Krátký +6 more
doaj +1 more source
Identification of Sequences Encoding Symbiodinium minutum Mitochondrial Proteins. [PDF]
, 2016 The dinoflagellates are an extremely diverse group of algae closely related to the Apicomplexa and the ciliates. Much work has previously been undertaken to determine the presence of various biochemical pathways within dinoflagellate mitochondria ...
Butterfield, Erin R. +2 more
core +4 more sources
Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages.
Journal of Clinical Investigation, 2019 Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle intermediates citrate, itaconate, and succinate.
David P. De Souza +11 more
semanticscholar +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source