Results 121 to 130 of about 344,376 (339)
An independently validated nomogram for isocitrate dehydrogenase-wild-type glioblastoma patient survival. [PDF]
, 2019 BackgroundIn 2016, the World Health Organization reclassified the definition of glioblastoma (GBM), dividing these tumors into isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant GBM, where the vast majority of GBMs are IDH-wild-type.
Barnholtz-Sloan, Jill S +6 more
core +1 more source
Cancer, 2018 Acute myeloid leukemia (AML) cells harboring mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) produce the oncometabolite 2‐hydroxyglutarate (2HG).
A. Brunner +24 more
semanticscholar +1 more source
Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity
Angewandte Chemie International Edition, EarlyView.A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt +14 more
wiley +1 more source
GC-MS Profile of Diodella sarmentosa (SW) Bacigalupo El Cabral ex Borhidi Ethanol Leaf Extract and its Total Dehydrogenase Inhibitory Potential [PDF]
arXiv, 2021 Phytochemical composition of ethanol leaf extract of Diodella sarmentosa was profiled with GC-MS and the inhibitory property of the extract against total microbial dehydrogenases were assessed. The major constituents of the extract were squalene (29.50%), Phytol (24.68%), phenol, 3-pentadecyl- (18.58%), 1-Butanol, 3-methyl- (9.09%) and n-Hexadecanoic ...
arxiv
Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view [PDF]
Electrophoresis 27 (04/2006) 1574-83, 2006 The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial rRNAs and a few tRNAs, we performed a comparative study on the 143B cell line and on its Rho-0 ...
arxiv +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Escherichia coli accumulates acetate as a byproduct in fast growth aerobic conditions when using glucose as carbon source. This phenomenon, known as overflow metabolism, has negative impacts on cell growth and protein expression, also causes carbon loss during biosynthesis in most microbial production scenarios. In this study, we regarded the “
Jianli Zhang +8 more
wiley +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk +4 more
wiley +1 more source
Biogenesis of Glyoxysomes [PDF]
, 1980 Biosynthesis of isocitrate lyase, a tetrameric enzyme of the glyoxysomal matrix, was studied in Neurospora crassa, in which the formation of glyoxysomes was induced by a substitution of sucrose medium by acetate medium. * 1.
Neupert, Walter, Zimmermann, Richard
core +1 more source
Cancer Discovery, 2016 UNLABELLED Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver bile duct malignancy exhibiting frequent isocitrate dehydrogenase (IDH1/IDH2) mutations.
Supriya K. Saha +27 more
semanticscholar +1 more source