Results 131 to 140 of about 358,941 (349)

Enasidenib in the treatment of relapsed/refractory acute myeloid leukemia: an evidence-based review of its place in therapy. [PDF]

, 2019
Introduction: Acute myeloid leukemia (AML) remains a disease with high mortality, especially for older patients and those with relapsed/refractory (R/R) disease.
Galkin, Maria, Jonas, Brian A
core   +1 more source

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

Scientific Reports, 2017
Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that are mutated in a variety of cancers to confer a gain-of-function activity resulting in the accumulation of an oncometabolite, D-2-hydroxyglutarate (2-HG).
D. Urban, Natalia J Martinez, Mindy I. Davis, K. Brimacombe, Dorian M. Cheff, Tobie D. Lee, M. Henderson, S. Titus, R. Pragani, J. M. Rohde, Li Liu, Yuhong Fang, Surendra Karavadhi, P. Shah, Olivia W. Lee, Amy Q Wang, Andrew L. McIver, Hongchao Zheng, Xiaodong Wang, Xin Xu, A. Jadhav, A. Simeonov, M. Shen, M. Boxer, M. Hall   +24 more
semanticscholar   +1 more source

A real-world study of adverse drug reactions of two isocitrate dehydrogenase inhibitor based on the US FDA adverse event reporting system and VigiAccess databases

Frontiers in Pharmacology
Background and objectivesIsocitrate dehydrogenase (IDH) inhibitor drugs (Enasidenib, Ivosidenib) restore normal metabolism and epigenetic regulation in cells, offering a precision-targeted therapeutic option for acute myeloid leukemia (AML) patients with
Mengmeng Peng, Mengmeng Peng, Qian Guo, Zihan Dang, Baiquan Zhang, Manjuan Li, Manjuan Li, Zixuan Wang, Zixuan Wang, Xuemian Lu, Xuemian Lu, Jie Lin   +11 more
doaj   +1 more source

Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots

Biologia Plantarum, 2012
NADP-dependent isocitrate dehydrogenase (NADP-ICDH) catalyses the production of NADPH, which is an essential component in the cellular homeostasis. In Arabidopsis, the kinetic parameters (K m and V max) of cytosolic NADP-ICDH were different in leaves and
M. Leterrier, J. B. Barroso, J. M. Palma, F. J. Corpas   +3 more
doaj   +1 more source

Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase

Cell Discovery, 2020
Human NAD-dependent isocitrate dehydrogenase or HsIDH3 catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle. HsIDH3 exists and functions as a heterooctamer composed of the αβ and αγ heterodimers, and is regulated ...
Pengkai Sun, Yan Liu, Tengfei Ma, Jianping Ding   +3 more
doaj   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, EarlyView.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Liver dehydrogenase levels in rainbow trout, Salmo gairdneri, fed cyclopropenoid fatty acids and aflatoxin B1

Journal of Lipid Research, 1973
Cyclopropenoid fatty acids in the diet of rainbow trout caused significant reductions in liver protein and activity of glucose-6-phosphate dehydrogenase, NADP-linked isocitrate dehydrogenase, lactate dehydrogenase, and malate dehydrogenase.
S.L. Taylor, M.W. Montgomery, D.J. Lee
doaj   +1 more source

NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial

The Laryngoscope, EarlyView.
This 2‐year, single‐center, double‐blind study with a small sample size compared NAD+ and control groups in a randomized controlled trial for sudden sensorineural hearing loss (SSNHL). Results showed that NAD+ led to better hearing improvement from 7 days to 3 months and a shorter average recovery time compared to the control group.
Minqian Gao, Yingting Guan, Xuejing Yue, Hao Bao, Qianwen Li, Yiqing Zheng, Yongkang Ou, Haidi Yang   +7 more
wiley   +1 more source

Malignant Transformation of a Rosette-Forming Glioneuronal Tumor with IDH1 Mutation: A Case Report and Literature Review

World Neurosurgery: X, 2019
Background: Rosette-forming glioneuronal tumor (World Health Organization grade I) is considered as a benign tumor with very low potential for progression.
Ronie Romelean Jayapalan, Kein Seong Mun, Kum Thong Wong, Sheau Fung Sia   +3 more
doaj   +1 more source

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations

Cell Reports Medicine, 2021
Ingvild Hvinden, T. Cadoux-Hudson, C. Schofield, J. Mccullagh   +3 more
semanticscholar   +1 more source