Results 131 to 140 of about 344,376 (339)

Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma.

Neuro-Oncology, 2016
BACKGROUND The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) and accumulate the metabolite R-2-hydroxyglutarate (R-2HG). Prior studies showed that this metabolite can be detected
M. I. de la Fuente, R. Young, Jennifer Rubel, M. Rosenblum, J. Tisnado, S. Briggs, J. Arevalo-Perez, J. Cross, Carl Campos, K. Straley, Dongwei Zhu, Chuanhui Dong, Alissa A. Thomas, A. Omuro, C. Nolan, E. Pentsova, T. Kaley, J. Oh, R. Noeske, E. Maher, Changho Choi, P. Gutin, A. Holodny, K. Yen, L. Deangelis, I. Mellinghoff, S. Thakur   +26 more
semanticscholar   +1 more source

The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]

, 2008
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core   +1 more source

Location and type of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia [PDF]

, 2012
Background: Mutations of isocitrate dehydrogenase 1 and 2 are novel common genetic alterations identified in acute myeloid leukemia. Aims: To investigate the frequency, clinical associations and prognostic effect of isocitrate dehydrogenase 1 and 2 ...
Adam, Emma, Andrikovics, Hajnalka, Batai, Arpad, Bors, Andras, Csomor, Judit, Dolgos, Janos, Feczko, Angela, Fekete, Sandor, Karaszi, Eva, Koszarska, Magdalena, Kozma, Andras, Lehoczky, Eniko, Lovas, Nora, Masszi, Tamas, Matrai, Zoltan, Meggyesi, Nóra, Orbán, Tamás I., Reichardt, Judit, Sipos, Andrea, Tordai, Attila   +19 more
core   +1 more source

Isocitrate Dehydrogenase (IDH)1/2 Mutations as Prognostic Markers in Patients With Glioblastomas

Medicine, 2016
The purpose of this study was to perform a meta-analysis examining the association of isocitrate dehydrogenase (IDH)1/2 mutations with overall survival (OS) and progression-free survival (PFS) in patients with glioblastomas.Medline, Cochrane, EMBASE, and
Jun-rui Chen, Yu Yao, Hong-zhi Xu, Zhiyong Qin   +3 more
semanticscholar   +1 more source

The representation of protein complexes in the Protein Ontology [PDF]

, 2011
Representing species-specific proteins and protein complexes in ontologies that are both human and machine-readable facilitates the retrieval, analysis, and interpretation of genome-scale data sets.
Arighi, Cecilia, Blake, Judith, Bult, Carol, Drabkin, Harold, D’Eustachio, Peter, Evsikov, Alexei, Natale, Darren, Roberts, Natalia, Ruttenberg, Alan, Smith, Barry, Wu, Cathy   +10 more
core  

Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis [PDF]

, 2005
Introduction: Acute metabolic acidosis of non-renal origin is usually a result of either lactic or ketoacidosis, both of which are associated with a high anion gap.
Forni, L.G., Hilton, P.J., Lord, Gwyn A., McKinnon, W., Peron, J.M.R., Treacher, D.F.   +5 more
core   +2 more sources

Interactions among mitochondrial proteins altered in glioblastoma [PDF]

, 2014
Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral to mitochondrial function.
A Acharya, A Herrmann, AG Herrmann, Alice M. J. Gerth, AM Gallegos, B Venkatesan, BB Ordys, C Miller, CE Griguer, CK Thorpe, DS Ziegler, DW Kang, DY Jin, DY Noh, E Anderson, F Forner, FB Furnari, G Bernard, G Dennis, H Barsnes, H Yan, HJ Lee, Ian R. Whittle, IR Griffiths, James McCulloch, JE Payton, JH Park, JM Cuezva, Julia M. Edgar, KA Sacksteder, L Dang, Lorraine E. Kerr, M Darsigny, MA Nikiforov, Mailis McCulloch, ME Cullen, MS Alphey, N Hempel, PR Rich, R Brigelius-Flohe, R James, R Moreno-Sanchez, RF Deighton, RF Deighton, RJ Shaw, Ruth F. Deighton, RY Lupertz, Sarah F. Martin, SM Cortes, T Bihan Le, T Kanekura, Thierry Le Bihan, TN Seyfried, VL Kinnula, W Huang da, W Tang, Y Fu, Z Yang, Z-Y Li   +58 more
core   +4 more sources

Potent immunosuppressive effects of the oncometabolite R-2-hydroxyglutarate

OncoImmunology, 2018
Somatic gain-of-function mutations in isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1) or isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) are bona fide oncogenic drivers of acute myeloid leukemia and glioma because the neomorphic enzymes
Lorenzo Galluzzi, Guido Kroemer
doaj   +1 more source

SERUM TRANSAMINASES AND ISOCITRIC DEHYDROGENASE IN KWASHIORKOR [PDF]

Journal of Clinical Pathology, 1960
Serum glutamic oxalacetic transaminase (G-OT), glutamic-pyruvic transaminase (G-PT), and isocitric dehydrogenase (ICD) have been estimated in six groups of subjects, namely, normal British adults, normal Nigerian adults, undernourished Nigerian adults and children, Nigerian children with florid protein malnutrition (kwashiorkor), and cases of protein ...
openaire   +3 more sources

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source