Results 141 to 150 of about 348,301 (394)

Interactions among mitochondrial proteins altered in glioblastoma [PDF]

, 2014
Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral to mitochondrial function.
A Acharya, A Herrmann, AG Herrmann, Alice M. J. Gerth, AM Gallegos, B Venkatesan, BB Ordys, C Miller, CE Griguer, CK Thorpe, DS Ziegler, DW Kang, DY Jin, DY Noh, E Anderson, F Forner, FB Furnari, G Bernard, G Dennis, H Barsnes, H Yan, HJ Lee, Ian R. Whittle, IR Griffiths, James McCulloch, JE Payton, JH Park, JM Cuezva, Julia M. Edgar, KA Sacksteder, L Dang, Lorraine E. Kerr, M Darsigny, MA Nikiforov, Mailis McCulloch, ME Cullen, MS Alphey, N Hempel, PR Rich, R Brigelius-Flohe, R James, R Moreno-Sanchez, RF Deighton, RF Deighton, RJ Shaw, Ruth F. Deighton, RY Lupertz, Sarah F. Martin, SM Cortes, T Bihan Le, T Kanekura, Thierry Le Bihan, TN Seyfried, VL Kinnula, W Huang da, W Tang, Y Fu, Z Yang, Z-Y Li   +58 more
core   +4 more sources

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Potent immunosuppressive effects of the oncometabolite R-2-hydroxyglutarate

OncoImmunology, 2018
Somatic gain-of-function mutations in isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1) or isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) are bona fide oncogenic drivers of acute myeloid leukemia and glioma because the neomorphic enzymes
Lorenzo Galluzzi, Guido Kroemer
doaj   +1 more source

5-hydroxymethylcytosine profiling as an indicator of cellular state [PDF]

, 2013
A Laird is supported by the Medical Research Council Scottish Clinical Pharmacology and Pathology Programme, The Royal College of Surgeons of Edinburgh Robertson’s Trust and The Melville Trust for the Care and Cure of Cancer.
Harrison, David J., Laird, Alexander, Meehan, Richard R., Thomson, John P.   +3 more
core   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, EarlyView.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

A strategy for multimodal integration of transcriptomics, proteomics, and radiomics data for the prediction of recurrence in patients with IDH‐mutant gliomas

International Journal of Cancer, EarlyView.
What's new? Isocitrate dehydrogenase (IDH)‐mutant gliomas typically affect young adults and invariably progress toward increasingly malignant phenotypes, despite treatment. Recurrence often is unpredictable, however, indicating a need for a deeper understanding of factors that drive disease return.
Tiffanie Chouleur, Christèle Etchegaray, Laura Villain, Antoine Lesur, Thomas Ferté, Marco Rossi, Laetitia Andrique, Costanza Simoncini, Anne‐Sophie Giacobbi, Matteo Gambaretti, Egesta Lopci, Bethania Fernades, Gunnar Dittmar, Rolf Bjerkvig, Boris Hejblum, Rodolphe Thiébaut, Olivier Saut, Lorenzo Bello, Andreas Bikfalvi   +18 more
wiley   +1 more source

Effects of mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency on fructose-induced obesity in mice [PDF]

, 2018
Obesity prevalence in the United States continues to increase and is associated with health consequences such as type 2 diabetes, hypertension, atherosclerosis, and hyperlipidemia.
Beane, Kaleigh Elizabeth, Montalbano, Allison Michelle   +1 more
core   +2 more sources

SERUM TRANSAMINASES AND ISOCITRIC DEHYDROGENASE IN KWASHIORKOR [PDF]

Journal of Clinical Pathology, 1960
Serum glutamic oxalacetic transaminase (G-OT), glutamic-pyruvic transaminase (G-PT), and isocitric dehydrogenase (ICD) have been estimated in six groups of subjects, namely, normal British adults, normal Nigerian adults, undernourished Nigerian adults and children, Nigerian children with florid protein malnutrition (kwashiorkor), and cases of protein ...
openaire   +3 more sources

Single‐microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut

iMeta, EarlyView.
The human body is inhabited by trillions of microorganisms that play a crucial role in health and diseases. Although our understanding of the species and functional composition of the human gut microbiome is rapidly expanding, species–function heterogeneity and dynamic activities in human microecosystem niches remain unclear.
Yifei Shen, Wenxin Qu, Mengdi Song, Tianyu Zhang, Chang Liu, Xiaofeng Shi, Xinxin Xu, Jingjing Jiang, Liguo Ding, Fangyu Mo, Zheying Mao, Mingzhu Huang, Ziye Xu, Jiaye Chen, Enhui Shen, Jian Ruan, Jiong Liu, Michael P. Timko, Yu Chen, Longjiang Fan, Shufa Zheng, Yongcheng Wang   +21 more
wiley   +1 more source

Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]

, 2019
York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core   +1 more source