Results 161 to 170 of about 358,941 (349)

The Key Enzymes of Carbon Metabolism and the Glutathione Antioxidant System Protect Yarrowia lipolytica Yeast Against pH-Induced Stress

Journal of Fungi
In this study, we first thoroughly assayed the response of the key enzymes of energy metabolism and the antioxidant system in Yarrowia lipolytica yeast at extreme pH.
Tatyana I. Rakhmanova, Natalia N. Gessler, Elena P. Isakova, Olga I. Klein, Yulia I. Deryabina, Tatyana N. Popova   +5 more
doaj   +1 more source

Reconstruction of an in silico metabolic model of _Arabidopsis thaliana_ through database integration [PDF]

, 2009
The number of genome-scale metabolic models has been rising quickly in recent years, and the scope of their utilization encompasses a broad range of applications from metabolic engineering to biological discovery.
Albert Gevorgyan, Jean-Marc Schwartz, Karin Radrich, Neil Swainston, Paul Dobson, Yoshimasa Tsuruoka   +5 more
core   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

FGFR2 Fusions or Rearrangements in Young Intrahepatic and Perihilar Cholangiocarcinoma Patients: Key Genetic Insights From a Pan‐Asian Study

Hepatology Research, EarlyView.
FGFR2 Alterations in Young Adults with cholangiocarcinoma was common. Intrahepatic cholangiocarcinoma (ICC) is a rare liver cancer, typically seen in older adults. This study focused on younger patients across Asia, examining changes in the FGFR2 gene that may drive cancer growth.
Yuta Maruki, Yasushi Yatabe, Chiharu Mizoguchi, Kathleen Yasmin de Almeida, Aumkhae Sookprasert, Charuwan Akewanlop, Ming‐Huang Chen, Ekaphop Sirachainan, Dao Van Tu, Rozita Abdul Malik, Chaiyut Charoentum, Hwoei Fen Soo Hoo, Suhana Yusak, Tsung‐Hao Liu, Rangasamy Ramachandran, Patrapim Sunpaweravong, Pei Jye Voon, Najihah Abu Bakar, Junki Mizusawa, Hitomi Sumiyoshi Okuma, Kenichi Nakamura, Chigusa Morizane, Takuji Okusaka   +22 more
wiley   +1 more source

Ontogeny of escape response and body shape in threespine stickleback (Gasterosteus aculeatus L.)

Journal of Fish Biology, EarlyView.
Abstract Escape responses in fishes provide insight into accelerative motions and behavioural response times of these animals, linking numerous fitness‐related traits. We sought to connect escape response performance to genotype and phenotype across ontogenetic stages within a single population of threespine stickleback (Gasterosteus aculeatus L.) to ...
Aspen M. Kozak, Michael Chung, Sean M. Rogers, Kelsey N. Lucas, Heather A. Jamniczky   +4 more
wiley   +1 more source

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. [PDF]

, 2018
Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutarate (D2HG ...
Badur, Mehmet G, Cordes, Thekla, Guan, Kun-Liang, Ma, Shenghong, Magana, Jose H, McBrayer, Samuel K, Metallo, Christian M, Muthusamy, Thangaselvam, Parker, Seth J   +8 more
core  

Epigenetic Regulation in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch, Arne Sönke Schäfer, Denica Kuzmanova, Dominique S. Michaud   +3 more
wiley   +1 more source

The representation of protein complexes in the Protein Ontology [PDF]

, 2011
Representing species-specific proteins and protein complexes in ontologies that are both human and machine-readable facilitates the retrieval, analysis, and interpretation of genome-scale data sets.
Arighi, Cecilia, Blake, Judith, Bult, Carol, Drabkin, Harold, D’Eustachio, Peter, Evsikov, Alexei, Natale, Darren, Roberts, Natalia, Ruttenberg, Alan, Smith, Barry, Wu, Cathy   +10 more
core  

Withaferin A suppresses skin tumor promotion by inhibiting proteasome-dependent isocitrate dehydrogenase 1 degradation [PDF]

, 2019
Kaiyue Xu, Chunjing Zhang, Youbo Li, Xi Xin, Lishuang Zheng, Ming Meng, Tong‐Tong Liu, Yunfeng Zhao, Wenjuan Li   +8 more
openalex   +1 more source

Microbiome and Metaproteome of Craniofacial Implant Regions in Health and Disease

Oral Diseases, EarlyView.
ABSTRACT Background Craniofacial defects from cancer surgery led to functional, aesthetic, and psychological challenges. Rehabilitation with craniofacial implants addresses these issues by improving prosthesis retention through osseointegration and providing predictable cosmetic results. However, maintaining a healthy transcutaneous region is essential
Daniela Lattuf Cortizo, Renato C. V. Casarin, Hélvis E. S. Paz, Camila S. Stolf, Mabelle F. Monteiro, Mônica T. V. Labate, Márcio Z. Casati, Luciano Lauria Dib   +7 more
wiley   +1 more source