Results 161 to 170 of about 5,434 (218)

Multicomponent Reactions with Isocyanides

Angewandte Chemie - International Edition, 2000
Multicomponent reactions (MCRs) are fundamentally different from two-component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic-chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low-molecular druglike compounds.
Alexander Domling, Ivar Ugi
exaly   +3 more sources

The Nef Reaction of Isocyanides

Synthesis, 2014
The interaction of isocyanides with acyl chlorides was first reported by Nef in 1892. The resulting α-keto imidoyl chlorides may be hydrolyzed to form α-keto amides. Relatively few data are available on this reaction and the chemistry of α-keto imidoyl chlorides has been largely underestimated until some recent uses in intra­- and intermolecular ...
Fabio La Spisa, TRON, Gian Cesare, Laurent El Kaim   +2 more
openaire   +4 more sources

Isocyanides

2022
Isocyanides are powerful functionalities by virtue of the carbene-like terminal carbon that imparts unique reactivity. Capable of functioning as electrophiles, nucleophiles, radical acceptors, and in transition metal-catalyzed insertions, isocyanides engage in a plethora of methodologies that generate complex molecules from relatively simple starting ...
Abdullah Bilal Altundas, Fraser F. Fleming   +1 more
openaire   +1 more source

Palladium-Catalyzed Migratory Insertion of Isocyanides: An Emerging Platform in Cross-Coupling Chemistry

Angewandte Chemie - International Edition, 2013
Isocyanides have been important building blocks in organic synthesis since the discovery of the Ugi reaction and related isocyanide-based multicomponent reactions. In the past decade isocyanides have found a new application as versatile
Eelco Ruijter, Bert U W Maes, Romano Orru   +2 more
exaly   +2 more sources

Fluoromethyl isocyanide and difluoromethyl isocyanide

Journal of Fluorine Chemistry, 1991
Abstract Whereas methyl isocyanide is known since more than a hundred years, the chemistry of its perfluorinated derivative CNCF 3 , has been developed only recently. Both compounds differ drastically. Herein we report the syntheses of the missing partially fluorinated compounds CNCH 2 F and CNCHF 2 via their pentacarbonyl chromium complexes.
Dagmar Preugschat, Dieter Lentz
openaire   +1 more source

Isocyanide insertion reactions. The role of isocyanide insertions in the metal assisted hydrogenation of isocyanides

Journal of the American Chemical Society, 1978
H/sub 2/Os/sub 3/(CO)/sub 10/ was reacted with phenyl isocyanide to form H/sub 2/Os/sub 3/(CO)/sub 10/(CNC/sub 6/H/sub 5/), which upon refluxing loses 1 mol CO to form a new complex that is believed to be a possible intermediate in the phenyl isocyanide reduction process. The molecular structure of the last complex was determined. (DLC)
Richard D. Adams, Nancy M. Golembeski
openaire   +1 more source

Isocyanide-Based Multicomponent Reaction ‘without’ Isocyanides

Synlett, 2009
We present here a one-pot, four-component sequence that affords Ugi-type adducts starting from simple benzyl or allyl bromides. The isocyanides are prepared in situ under alkylation of silver cyanide salts and the resulting mixture is directly used in a Ugi―Smiles coupling.
El Kaim, Laurent, Grimaud, Laurence, Schiltz, Aurelie   +2 more
openaire   +2 more sources

2,4,6-Trimethylphenyl isocyanide

Acta Crystallographica Section C Crystal Structure Communications, 2002
The title compound, C(10)H(11)N, displays a crystallographic mirror plane that incorporates all the non-H atoms, as well as the H atoms attached to the aromatic ring. The isocyano group is almost linear and shows an N[triple bond]C bond distance of 1.158 (3) A.
Manuel A, Fernandes, Marcus, Layh, Bernard, Omondi   +2 more
openaire   +2 more sources

Microchemical detection of isocyanides

Talanta, 1967
Microgram quantities of isocyanides may be easily detected on filter paper or in tubes of silica gel by using benzidine acetate-copper(II) acetate or p,p'-tetramethyldiaminodiphenylmethane-copper(II) sulphate reagents. Interferences include those substances which are known to interfere in the use of the same reagents for the detection of hydrogen ...
E V, Crabtree, E J, Poziomek, D J, Hoy
openaire   +2 more sources

Synthesis of α-Amino Isocyanides and α-Alkylthio Isocyanides

Synthesis, 1993
α-Morpholinobenzyl isocyanide and three 1-(aryl[or alkyl]thio)alkyl isocyanides are synthesized in good yields by the dehydration of N-(α-morpholinobenzyl)formamide and N-[1-(alkylthio)alkyl]formamides, themselves prepared from 1-(1-formylaminoalkyl)benzotriazoles with morpholine or with ...
Alan R. Katritzky, Linghong Xie, Wei-Qiang Fan   +2 more
openaire   +1 more source