Catalytic Enantioselective Synthesis of Oxazolines with Vinylogous Isocyano Esters. [PDF]
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Nitrone chemistry: a versatile gateway to diverse heterocycles. [PDF]
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Deuterated reagents in multicomponent reactions to afford deuterium-labeled products. [PDF]
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Atroposelective synthesis of axially chiral imidazo[1,2-a]pyridines via asymmetric multicomponent reaction. [PDF]
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General Approach to Amides through Decarboxylative Radical Cross-Coupling of Carboxylic Acids and Isocyanides. [PDF]
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Multicomponent Reactions with Isocyanides
Angewandte Chemie - International Edition, 2000Multicomponent reactions (MCRs) are fundamentally different from two-component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic-chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low-molecular druglike compounds.
Alex Domling
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Isocyanides are powerful functionalities by virtue of the carbene-like terminal carbon that imparts unique reactivity. Capable of functioning as electrophiles, nucleophiles, radical acceptors, and in transition metal-catalyzed insertions, isocyanides engage in a plethora of methodologies that generate complex molecules from relatively simple starting ...
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