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Multicomponent Reactions with Isocyanides
Angewandte Chemie - International Edition, 2000Multicomponent reactions (MCRs) are fundamentally different from two-component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic-chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low-molecular druglike compounds.
Alexander Domling
exaly +3 more sources
2022
Isocyanides are powerful functionalities by virtue of the carbene-like terminal carbon that imparts unique reactivity. Capable of functioning as electrophiles, nucleophiles, radical acceptors, and in transition metal-catalyzed insertions, isocyanides engage in a plethora of methodologies that generate complex molecules from relatively simple starting ...
Abdullah Bilal Altundas +1 more
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Isocyanides are powerful functionalities by virtue of the carbene-like terminal carbon that imparts unique reactivity. Capable of functioning as electrophiles, nucleophiles, radical acceptors, and in transition metal-catalyzed insertions, isocyanides engage in a plethora of methodologies that generate complex molecules from relatively simple starting ...
Abdullah Bilal Altundas +1 more
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Fluoromethyl isocyanide and difluoromethyl isocyanide
Journal of Fluorine Chemistry, 1991Abstract Whereas methyl isocyanide is known since more than a hundred years, the chemistry of its perfluorinated derivative CNCF 3 , has been developed only recently. Both compounds differ drastically. Herein we report the syntheses of the missing partially fluorinated compounds CNCH 2 F and CNCHF 2 via their pentacarbonyl chromium complexes.
Dagmar Preugschat, Dieter Lentz
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Journal of the American Chemical Society, 1978
H/sub 2/Os/sub 3/(CO)/sub 10/ was reacted with phenyl isocyanide to form H/sub 2/Os/sub 3/(CO)/sub 10/(CNC/sub 6/H/sub 5/), which upon refluxing loses 1 mol CO to form a new complex that is believed to be a possible intermediate in the phenyl isocyanide reduction process. The molecular structure of the last complex was determined. (DLC)
Richard D. Adams, Nancy M. Golembeski
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H/sub 2/Os/sub 3/(CO)/sub 10/ was reacted with phenyl isocyanide to form H/sub 2/Os/sub 3/(CO)/sub 10/(CNC/sub 6/H/sub 5/), which upon refluxing loses 1 mol CO to form a new complex that is believed to be a possible intermediate in the phenyl isocyanide reduction process. The molecular structure of the last complex was determined. (DLC)
Richard D. Adams, Nancy M. Golembeski
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Isocyanide-Based Multicomponent Reaction ‘without’ Isocyanides
Synlett, 2009We present here a one-pot, four-component sequence that affords Ugi-type adducts starting from simple benzyl or allyl bromides. The isocyanides are prepared in situ under alkylation of silver cyanide salts and the resulting mixture is directly used in a Ugi―Smiles coupling.
El Kaim, Laurent +2 more
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2,4,6-Trimethylphenyl isocyanide
Acta Crystallographica Section C Crystal Structure Communications, 2002The title compound, C(10)H(11)N, displays a crystallographic mirror plane that incorporates all the non-H atoms, as well as the H atoms attached to the aromatic ring. The isocyano group is almost linear and shows an N[triple bond]C bond distance of 1.158 (3) A.
Manuel A, Fernandes +2 more
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Microchemical detection of isocyanides
Talanta, 1967Microgram quantities of isocyanides may be easily detected on filter paper or in tubes of silica gel by using benzidine acetate-copper(II) acetate or p,p'-tetramethyldiaminodiphenylmethane-copper(II) sulphate reagents. Interferences include those substances which are known to interfere in the use of the same reagents for the detection of hydrogen ...
E V, Crabtree, E J, Poziomek, D J, Hoy
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Synthesis of α-Amino Isocyanides and α-Alkylthio Isocyanides
Synthesis, 1993α-Morpholinobenzyl isocyanide and three 1-(aryl[or alkyl]thio)alkyl isocyanides are synthesized in good yields by the dehydration of N-(α-morpholinobenzyl)formamide and N-[1-(alkylthio)alkyl]formamides, themselves prepared from 1-(1-formylaminoalkyl)benzotriazoles with morpholine or with ...
Alan R. Katritzky +2 more
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Homoleptic Isocyanide Metalates
Angewandte Chemie International Edition, 1998Novelties and surprises in the chemistry of metal isocyanides: The synthesis and structure determination of homoleptic isocyanide metalates [M(CNXyl)m ]- (M=Co, m=4; M=Mn, m=5; Xyl=2,6-Me2 C6 H3 ) indicate that we need to revise our understanding of transition metal-isocyanide interactions.
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Isocyanides and Their Heteroanalogs (RZC)
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
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