Results 71 to 80 of about 431 (112)

A comparative study of the pharmacokinetics of isometamidium chloride in sheep and goats

Small Ruminant Research, 2004
Abstract A study was carried out to determine and compare the pharmacokinetics of isometamidium in groups of six animals each of sheep and goats treated by intramuscular injection with isometamidium chloride (Samorin ® , Rhone Merieux, Lyon, France) at 0.5 mg/kg body weight.
T W Jones
exaly   +3 more sources

HPTLC and HPLC determination of isometamidium in the presence of its manufacturing and degradation impurities

Journal of Pharmaceutical and Biomedical Analysis, 1998
The determination of the phenanthridine trypanocide, isometamidium chloride hydrochloride (ISM), in the presence of four process-related and degradation impurities, by RP-HPLC using a Licrospher-60 RP-select B column with a mobile phase composition of acetonitrile/KH2PO4 (PH 3.0, 20 mM) (25:75 v/v) with UV detection at 320 nm, is described.
G G Skellern, M H Grant, M H Grant
exaly   +3 more sources

Development of a radioimmunoassay for isometamidium

Veterinary Research Communications, 1988
A radioimmunoassay for the trypanocidal drug isometamidium (ISMM) has been developed using antibodies produced in sheep immunized against the drug cross-linked to human serum albumin. With 14C-ISMM as a radioligand, cross-reactivity of the antibodies was determined and found to be less than 3% with pyrithidium, diminazene and quinapyramine and about 13%
L D, Kinabo, J A, Bogan
openaire   +2 more sources

Effect of isometamidium on Trypanosoma congolense infectivity

Veterinary Parasitology, 1991
Isometamidium chloride (Samorin, RMB, England) is a widely used and highly effective trypanocide for the treatment of bovine trypanosomiases. However, the appearance of isometamidium-resistant populations of T. congolense in Africa makes it necessary to develop methods for the rapid and reliable detection of drug resistance in the laboratory. Currently
I A, Sutherland, A, Mounsey, P H, Holmes
openaire   +2 more sources

Pharmacokinetic and histopathological investigations of isometamidium in cattle

Research in Veterinary Science, 1988
The absorption and distribution patterns of the trypanocidal drug isometamidium and its effect on tissues in cattle were characterised. After intramuscular administration of a prophylactic dose of 0.5 mg kg-1 bodyweight, the drug was rapidly detectable in serum at a mean maximum concentration of only 20 ng ml-1 and declined to concentrations of lower ...
L D, Kinabo, J A, Bogan
openaire   +2 more sources

Acute toxicity of samorin (Isometamidium chloride) in rabbits

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1984
Oral administration of samorin (isometamidium chloride) to rabbits in single oral doses of 6.25, 12.5, 25 and 50 mg/kg produced signs of toxicity which were dose-dependent. These were restlessness, hyperaesthesia, tremors, convulsions and finally death.
B H, Ali, E M, Haroun
openaire   +2 more sources

Preliminary pharmacokinetic study of isometamidium chloride in camels

Research in Veterinary Science, 1984
Isometamidium chloride was given to camels at a single intravenous dose rate of 0.5 or 1 mg kg-1 and the plasma drug concentration measured spectrophotometrically at frequent intervals for up to 48 hours. Isometamidium chloride concentrations were found to be 9.8 +/- 0.2 and 8.7 +/- 0.2 micrograms ml-1 half an hour after treatment with 1 and 0.5 mg kg ...
B H, Ali, T, Hassan
openaire   +2 more sources

The appearance of isometamidium resistant "Trypanosoma congolense" in West Africa

Acta tropica, 1984
The frequent reappearance of patent parasitemia, mainly Trypanosoma congolense, in cattle maintained under isometamidium prophylaxis in the Upper Volta indicated that drug-resistant forms might be appearing. To investigate this possibility, trypanosome stocks were isolated in mice, their isometamidium sensitivity estimated and compared to that of ...
M, Pinder, E, Authie
openaire   +2 more sources

The Toxic Effect of Intravenous Application of the Trypanocide Isometamidium (Samorin®)

Zentralblatt für Veterinärmedizin Reihe A, 1985
SummaryFor the trypanocide isometamidium chloride (Samorin®, May & Baker) the intramuscular route is recommended by the suppliers but application by this route is followed by local tissue irritation and necrosis. The intravenous administration leads to a dose‐dependent acute systemic toxicity, which can be fatal.
D, Schillinger, S H, Maloo, D, Röttcher
openaire   +2 more sources

Susceptibility of dyskinetoplastic Trypanosoma evansi and T. equiperdum to isometamidium chloride

Parasitology Research, 1997
Isometamidium chloride (ISM) is an effective trypanocide with curative and prophylactive activity in husbandry animals. The mode of action of ISM against pathogenic trypanosomes is not fully understood, but there is evidence in the literature that kinetoplastic topoisomerase type II is selectively inhibited by the drug.
Kaminsky R, Schmid C, Lun ZR
openaire   +3 more sources