Results 51 to 60 of about 1,705 (235)

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase.

PLoS Neglected Tropical Diseases, 2016
BackgroundIsometamidium is the main prophylactic drug used to prevent the infection of livestock with trypanosomes that cause Animal African Trypanosomiasis.
Anthonius A Eze, Matthew K Gould, Jane C Munday, Daniel N A Tagoe, Valters Stelmanis, Achim Schnaufer, Harry P De Koning   +6 more
doaj   +1 more source

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
core   +1 more source

Assessment of the Resistance of Cattle Trypanosomes to Diminazene Aceturate and Isometamidium Chloride on the Adamawa Plateau in Cameroon Using a Field Test and a Test in Mice

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2006
Based on a survey in a few villages of the department of Faro et Deo, the village of Kontcha, where the highest trypanosomosis prevalence (32.5%) was observed, was selected to evaluate the resistance of trypanosomes to diminazene and isometamidium.
A. Mamoudou, A. Zoli, C. Tanenbe, J. P. Andrikaye, M. Bourdanne, T. Marcotty, V. Delespaux, P.H. Clausen, S. Geerts   +8 more
doaj   +1 more source

Occurrence of multiple drug resistance in Trypanosoma brucei rhodesiense isolated from sleeping sickness patients

Onderstepoort Journal of Veterinary Research, 2007
The occurrence of cross-resistance among melarsoprol-resistant Trypanosoma brucei rhodesiense isolates was investigated in this study. The isolates, T. b. rhodesiense KETRI 237, 2538, 1992, 2709, 2694 and 3530, had been obtained from sleeping sickness
N. Maina, J.M. Kagira
doaj   +1 more source

Drug Resistant Trypanosomes: a Threat to Cattle Production in the Southwest of Ethiopia

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2003
Trypanosomosis is an important disease of cattle in the southwest of Ethiopia. At present chemotherapy and chemoprophylaxis are the only practical methods available for the control of animal trypanosomosis, but their effectiveness is being eroded by the ...
H. Chaka, G. Abébé
doaj   +1 more source

Isothermal microcalorimetry – A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses.
M. Gysin, O. Braissant, K. Gillingwater, R. Brun, P. Mäser, T. Wenzler   +5 more
doaj   +1 more source

Assessment of animal African trypanosomiasis (AAT) vulnerability in cattle-owning communities of sub-Saharan Africa [PDF]

, 2016
Background: Animal African trypanosomiasis (AAT) is one of the biggest constraints to livestock production and a threat to food security in sub-Saharan Africa.
A Hagos, A Mamoudou, A Mamoudou, A Mamoudou, A Miruk, A Soudré, A Sow, A Teko-Agbo, APM Shaw, C Waiswa, C. Mumba, D Grace, D Muhanguzi, EH Waaij van der, G Cecchi, G Hendrickx, G Rowlands, G. B. Napier, GA Vale, GK Fuller, H Buyst, H Simukoko, H. R. Holt, J Bouyer, J McDermott, J Woodford, J. Guitian, L Sinyangwe, M Abdoulmoumini, M Chanie, M Pinder, M Simon-Grifé, MJB Vreysen, N Machila, N Machila, NE Anderson, OD Cardona, P Bossche Van den, P Solano, PP Simarro, R Fikru, R Selby, R. Selby, S Costard, S Tasew, V Delespaux   +45 more
core   +6 more sources