Results 31 to 40 of about 527 (157)

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase.

PLoS Neglected Tropical Diseases, 2016
BackgroundIsometamidium is the main prophylactic drug used to prevent the infection of livestock with trypanosomes that cause Animal African Trypanosomiasis.
Anthonius A Eze, Matthew K Gould, Jane C Munday, Daniel N A Tagoe, Valters Stelmanis, Achim Schnaufer, Harry P De Koning   +6 more
doaj   +1 more source

In Vitro Uptake of Isometamidium and Diminazene by Trypanosoma brucei [PDF]

Antimicrobial Agents and Chemotherapy, 1974
The cattle trypanocide, isometamidium, was readily taken up by inactivated Trypanosoma brucei , while its uptake by living parasites was reduced or inhibited by plasma. In both respects isometamidium differs from diminazene.
P, Girgis-Takla, D M, James
openaire   +2 more sources

Prevalence and Associated Risk Factors of African Animal Trypanosomiasis in Cattle in Lambwe, Kenya

Journal of Parasitology Research, Volume 2022, Issue 1, 2022., 2022
Background. African animal trypanosomiasis (AAT) affects livestock productivity in sub‐Saharan Africa. This study aimed to determine cattle AAT’s prevalence and associated risk factors in Lambwe Valley, Kenya. Methods. In a cross‐sectional survey, livestock owners were recruited from four villages of Lambwe in Homa Bay, Kenya.
Ivy Okello, Eliakunda Mafie, Gillian Eastwood, Jahashi Nzalawahe, Leonard E. G. Mboera, Samuel Onyoyo, José F. Silveira   +6 more
wiley   +1 more source

Study of plasma protein binding activity of isometamidium and its impact on anthelmintic activity using trypanosoma induced calf model

Veterinary World, 2013
Aim: The objective of present study was to determine Plasma Protein Binding (PPB) activity and its effect on clinical efficacy of isometamidium after intramuscular administration in calves.
Suprita Sinha, Shweta Anand, Tapan Kumar Mandal   +2 more
doaj   +1 more source

Effect of isometamidium hydrochloride on Trypanosoma evansi infections in rats [PDF]

Journal of Parasitic Diseases, 2009
Effect of Isometamidium treatment of rats infected with Trypanosoma evansi was studied under experimental condition. The infection resulted in 100 per cent mortality by 7 day post treatment (DPT) in the infected untreated rats (Gr.II) and Isometamidium-HCl exerted 90 percent anti-trypanosomal efficacy.
Upendra, Kumar, Ruma, Jas, J D, Ghosh
openaire   +2 more sources

Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential

Molecular Microbiology, Volume 116, Issue 2, Page 564-588, August 2021., 2021
Resistance to diminazene is one of the main problems facing the control of the livestock disease Animal African Trypanosomiasis (AAT, or nagana), caused by the parasite Trypanosoma congolense. We investigated the adaptations of the parasite that allow it to resist the drug and find that changes to the mitochondrion, where the parasite produces its ...
Lauren V. Carruthers, Jane C. Munday, Godwin U. Ebiloma, Pieter Steketee, Siddharth Jayaraman, Gustavo D. Campagnaro, Marzuq A. Ungogo, Leandro Lemgruber, Anne‐Marie Donachie, Tim G. Rowan, Rose Peter, Liam J. Morrison, Michael P. Barrett, Harry P. De Koning   +13 more
wiley   +1 more source

Prevalence of Bovine Trypanosomosis and Its Associated Risk Factor in Hawa Galan District, Kelem Wollega Zone of Ethiopia

Veterinary Medicine International, Volume 2021, Issue 1, 2021., 2021
An analytical cross‐sectional study was performed between November 2015 and April 2016 at Hawa Galan woreda, Kelem Wollega Zone, Oromia Region, Ethiopia, to estimate the proportion of cattle with trypanosomosis and to evaluate the elements associated with the prevalence of bovine trypanosomosis.
Girma Tsegaye, Belay Abebe, Geremew Haile, Remo Lobetti   +3 more
wiley   +1 more source

Evaluation of isometamidium levels in the serum of sheep and goats after prophylactic treatment against trypanosomosis

Onderstepoort Journal of Veterinary Research, 2004
years, but recently there have been reports of prophylaxis failure under natural conditions. In this study, use of the drug for prophylactic purpose against trypanosomosis in small ruminants was investigated.
J.O. Wesongah, G.A. Murilla, J.K. Kibugu, T.W. Jones   +3 more
doaj   +1 more source

Antiprotozoal Drug Handling and Management Practices in Asella District, Central Oromia, Ethiopia

Veterinary Medicine International, Volume 2021, Issue 1, 2021., 2021
Background and Methods. Protozoal infections such as dourine caused by trypanosomes are found to be a threat to the life and productivity of the equine population. Inappropriate drug use is a problem of the whole world; however, the degree of the problem is higher in developing countries like Ethiopia.
Ashenafi Ababu, Dereje Endashaw, Haben Fesseha, Mesfin Mathewos, Carlos Alberto Hussni   +4 more
wiley   +1 more source

Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense [PDF]

Biochemical Journal, 1993
Isometamidium chloride (Samorin) is the only compound recommended for prophylaxis against bovine trypanosomiasis in sub-Saharan Africa. The fluorescence property of this compound was used to investigate the interaction of the molecule with in vitro-derived bloodstream forms of Trypanosoma congolense IL 1180.
Zilberstein, D., Wilkes, J.M., Hirumi, H., Peregrine, A.S.   +3 more
openaire   +2 more sources