Results 41 to 50 of about 484 (116)

Laboratory and Field Evaluation of Biodegradable Polyesters for Sustained Release of Isometamidium and Ethidium

open access: yesMemorias do Instituto Oswaldo Cruz, 1999
An overview is presented of the results obtained with biodegradable sustained release devices (SRDs) containing a mixture of polymers and either isometamidium (ISMM) or ethidium. Under controlled laboratory conditions (monthly challenge with tsetse flies
S Geerts, JRA Brandt, R De Deken
doaj   +1 more source

Occurrence of multiple drug resistance in Trypanosoma brucei rhodesiense isolated from sleeping sickness patients

open access: yesOnderstepoort Journal of Veterinary Research, 2007
The occurrence of cross-resistance among melarsoprol-resistant Trypanosoma brucei rhodesiense isolates was investigated in this study. The isolates, T. b. rhodesiense KETRI 237, 2538, 1992, 2709, 2694 and 3530, had been obtained from sleeping sickness
N. Maina, J.M. Kagira
doaj   +1 more source

Drug Resistant Trypanosomes: a Threat to Cattle Production in the Southwest of Ethiopia

open access: yesRevue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2003
Trypanosomosis is an important disease of cattle in the southwest of Ethiopia. At present chemotherapy and chemoprophylaxis are the only practical methods available for the control of animal trypanosomosis, but their effectiveness is being eroded by the ...
H. Chaka, G. Abébé
doaj   +1 more source

Isothermal microcalorimetry – A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time

open access: yesInternational Journal for Parasitology: Drugs and Drug Resistance, 2018
Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses.
M. Gysin   +5 more
doaj   +1 more source

The susceptibility of Trypanosoma congolense isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride

open access: yesOnderstepoort Journal of Veterinary Research, 2005
Resistance to trypanocidal drugs has been detected in various African countries and is a serious impediment to the control of livestock trypanosomosis.
S. Jamal   +6 more
doaj   +1 more source

Follow-up of dairy cattle naturally infected by Trypanosoma vivax after treatment with isometamidium chloride

open access: yesRevista Brasileira de Parasitologia Veterinária, 2021
Trypanosoma vivax infections cause nonspecific clinical signs in cattle associated with aparasitemic intervals, making disease diagnosis a challenge.
Kayo José Garcia de Almeida Castilho Neto   +7 more
doaj   +1 more source

Protective efficacy of isometamidium chloride and diminazene aceturate against natural Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population in Uganda

open access: yesOnderstepoort Journal of Veterinary Research, 2004
The protective efficacy of isometamidium chloride (ISMM) and diminazene aceturate (DIM) against Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population was assessed in southeast Uganda.
J.W. Magona   +3 more
doaj   +1 more source

Aberrant use and poor quality of trypanocides: a risk for drug resistance in south western Ethiopia

open access: yesBMC Veterinary Research, 2018
Background Trypanocidal drugs have been used to control African animal trypanosomosis for several decades. In Ethiopia, these drugs are available from both authorized (legal) and unauthorized (illegal) sources but documentation on utilization practices ...
T. Tekle   +14 more
doaj   +1 more source

Effect of time of treatment on the efficacy of trypanocides in rats experimentally infected with Trypanosoma brucei brucei

open access: yesNotulae Scientia Biologicae, 2023
The effect of treatment time on the efficacy of trypanocides in rats experimentally infected with Trypanosoma brucei brucei was assessed. The thirty albino rats utilized in this study were divided into six groups, each with five rats.
Ikenna O. EZEH   +7 more
doaj   +1 more source

Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2010
BACKGROUND: Because of the development of resistance in trypanosomes to trypanocidal drugs, the livelihood of millions of livestock keepers in sub-Saharan Africa is threatened now more than ever.
Vincent Delespaux   +7 more
doaj   +1 more source

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