PLoS Neglected Tropical Diseases, 2010 Because of the development of resistance in trypanosomes to trypanocidal drugs, the livelihood of millions of livestock keepers in sub-Saharan Africa is threatened now more than ever. The existing compounds have become virtually useless and pharmaceutical companies are not keen on investing in the development of new trypanocides.
Delespaux, Vincent +7 more
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Kinetic modelling of isometamidium chloride (Samorin) uptake byTrypanosoma congolense
Parasitology, 1992 Clones ofTrypanosoma congolensewhich express resistance to the widely used trypanocide isometamidium chloride accumulate less of the drug than clones which are sensitive to drug treatment. A mathematical model has been developed which was able to predict theoretical lines representing the uptake kinetics in trypanosomes which were sensitive to ...
Sutherland, IA +3 more
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Nanoformulation of a Trypanocidal Drug Isometamidium Chloride Ameliorates the Apurinic-Apyrimidinic DNA Sites/Genotoxic Effects in Horse Blood Cells. [PDF]
J Xenobiot, 2023 Singh S +5 more
europepmc +1 more source
Vector competence of sterile male Glossina fuscipes fuscipes for Trypanosoma brucei brucei: implications for the implementation of the sterile insect technique in a sleeping sickness focus in Chad. [PDF]
Parasit Vectors, 2023 Mahamat MH +8 more
europepmc +1 more source
Trypanocide usage in the cattle belt of southwestern Uganda. [PDF]
Front Microbiol, 2023 Kasozi KI +3 more
europepmc +1 more source
STUDIES ON ISOMETAMIDIUM: THE EFFECT OF ISOMETAMIDIUM, HOMIDIUM AND PYRITHIDIUM ON THE INFECTIVITY OF TRYPANOSOMAS FOR MICE [PDF]
British Journal of Pharmacology and Chemotherapy, 1965 openaire +2 more sources
Variation of sensitivity of Trypanosoma evansi isolates from Isiolo and Marsabit counties of Kenya to locally available trypanocidal drugs. [PDF]
PLoS One, 2023 Mdachi RE +10 more
europepmc +1 more source
Determination of serum isometamidium levels in sheep and goats under field conditions using isometamidium-ELISAapplication/pdf Twenty eight sheep and 28 goats were treated with isometamidium chloride (Samorin®, hone Merieux, Lyon, France) at a dose of 1 mg/kg body weight (bw) by intramuscular injection. All the animals were grazed in a tsetse-infested area.
openaire
Prothidium and isometamidium as drug against Trypanosoma brucei canine trypanosomiasis
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1970 Le Prothidium et l'Isométamidium ont été utilisés dans le traitement de plusieurs cas de trypanosomiase expérimentale du chien à Trypanosoma brucei. Le Prothidium est administré à raison de 2 mg/kg de la solution à 2 p.100 et l'Isométamidium 1 mg/kg de la solution à 1 p.100.
openaire +3 more sources
An Update on African Trypanocide Pharmaceutics and Resistance. [PDF]
Front Vet Sci, 2022 Kasozi KI +3 more
europepmc +1 more source