Results 81 to 90 of about 431 (112)

A Simple Competitive Enzyme Immunoassay for the Detection of the Trypanocidal Drug Isometamidium

Therapeutic Drug Monitoring, 1996
A new competitive enzyme immunoassay technique has been developed for the determination of concentrations of the trypanocidal drug isometamidium chloride (Samorin) in bovine serum. The method has been shown to be highly repeatable and reproducible, and it has several advantages over previous immunoassay techniques for the drug.
Eisler, MC, Elliott, CT, Holmes, PH
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Isometamidium in pigs: disposition kinetics, tissue residues and adverse reactions

Research in Veterinary Science, 1991
The disposition and adverse effects of the anti-trypanosomal drug isometamidium in pigs were evaluated. Following intramuscular administration of the drug at doses of 0.5, 15 and 35 mg kg-1, the drug was rapidly absorbed within 15 to 30 minutes to reach maximum plasma concentrations of 12 to 477 (n = 6), 302 to 655 (n = 4) and 1620 (n = 1) ng ml-1 ...
L D, Kinabo, Q A, McKellar, P D, Eckersall   +2 more
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Isometamidium in goats: Disposition kinetics, mammary excretion and tissue residues

British Veterinary Journal, 1990
The pharmacokinetics of the antitrypanosomal drug isometamidium were studied in lactating goats after intravenous and intramuscular administration at a dose of 0.5 mg/kg body weight, in a crossover design at an interval of 6 weeks. Following intravenous administration, the half-life of the disappearance of the drug from plasma during the terminal phase
L D, Kinabo, Q A, McKellar
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Influence of atropine on the acute toxicity of isometamidium.

Veterinary and human toxicology, 1993
The effectiveness of atropine in blocking the acute toxic effects of the antitrypanosomal drug isometamidium (ISMM) was evaluated in mice and goats using lethality as the primary index. The median lethal dose (LD50) of ISMM in nonatropinized mice was 45.3 mg/kg bodyweight (SE +/- 5.3 mg/kg bodyweight), whereas the LD50 of ISMM in mice pre-treated with ...
A A, Gimbi, L D, Kinabo
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Metabolism of isometamidium in hepatocytes isolated from control and inducer‐treated rats

Journal of Veterinary Pharmacology and Therapeutics, 2006
Little is known about the metabolism and mechanism of action of the trypanocide, isometamidium (ISM), the major drug used for prophylaxis of trypanosomiasis. We have investigated its metabolism and distribution in isolated rat hepatocytes using liquid chromatography‐mass spectrometry and confocal laser scanning microscopy (CLSM).
I, Boibessot, J N A, Tettey, G G, Skellern, D G, Watson, M H, Grant   +4 more
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Pharmacokinetics and efficacy of isometamidium chloride against Trypanosoma vivax in cattle

Parasitology International
We evaluated the pharmacokinetics (pk), preventive efficacy (PE) and therapeutic efficacy (TE) of isometamidium chloride (ISM) against T. vivax. For the pk study, the animals received ISM 1 mg/kg (1 mL/40 kg) on day 0 and plasma samples were collected at day 0 (immediately before treatment), 1 h, 3 h 6 h, 9 h and 12 h after treatment, D + 1 (24 h and ...
Luiz Fellipe Monteiro, Couto, Dina Maria Beltrán, Zapa, Luciana Maffini, Heller, Thiago Souza Azeredo, Bastos, Luis Fernando, Vettorato, Heitor de Oliveira Arriero, Amaral, Rafael Marin, Chiummo, Daniel de Castro, Rodrigues, Vando Edésio, Soares, Lorena Lopes, Ferreira, Welber Daniel Zanetti, Lopes   +10 more
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Chromatographic and spectroscopic analysis of the components present in the phenanthridinium trypanocidal agent isometamidium

Analytical and Bioanalytical Chemistry, 2014
The chromatographic isolation and characterisation of the four compounds present in the quaternary phenanthridine veterinary trypanocidal agent, isometamidium chloride hydrochloride (ISM), is reported. The isolated compounds were unambiguously characterised using spectroscopic (NMR, UV, IR and MS) methods as 3-amino-8-[3-(3-carbamimidoyl-phenyl ...
John O, Igoli, Gavin, Blackburn, Alexander I, Gray, Oliver B, Sutcliffe, David G, Watson, Melvin R, Euerby, Graham G, Skellern   +6 more
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Action of isometamidium chloride on the insect vector form of Trypanosoma vivax

Research in Veterinary Science, 1985
The effect of isometamidium chloride upon developing and mature Trypanosoma vivax occurring in Glossina palpalis palpalis flies was evaluated. Newly emerged G p palpalis flies were infected with T vivax by allowing them to feed on parasitaemic animals. Two experiments were conducted and in each the flies were divided into two groups.
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Influence of nutrition on trypanosome isometamidium chloride chemoprophylaxis

Animal Research International, 2012
Thirty six weaner wistar rats were used to study the effect of protein nutrition on trypanosome isometamidium chloride prophylaxis. Two groups of rats A and B (n = 18 per group) were maintained on 21% and 14.5% crude protein diet respectively for the twenty eight days.
Nnadi, PA, Onyeyili, PA
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The pharmacology of isometamidium

Journal of Veterinary Pharmacology and Therapeutics, 1988
L D, Kinabo, J A, Bogan
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