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Isoniazid Preventive Therapy and Risk for Resistant Tuberculosis
In the context of tuberculosis (TB) resurgence, isoniazid preventive therapy (IPT) is increasingly promoted, but concerns about the risk for development of isoniazid-resistant tuberculosis may hinder its widespread implementation.
Maria Elvira Balcells+3 more
doaj +1 more source
INTRODUCTION: It is unclear what the optimal treatment regimen for previously treated patients with rifampicin-susceptible isoniazid resistant tuberculosis should be. Conflicting evidence exists as to the effectiveness of the WHO standardized category II
Christopher Kuaban+2 more
doaj +1 more source
Potential economic viability of two proposed rifapentine-based regimens for treatment of latent tuberculosis infection. [PDF]
Rifapentine-based regimens for treating latent tuberculosis infection (LTBI) are being considered for future clinical trials, but even if they prove effective, high drug costs may limit their economic viability.To inform clinical trial design by ...
David P Holland+3 more
doaj +1 more source
Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis [PDF]
Supported by the Global Alliance for TB Drug Development with support from the Bill and Melinda Gates Foundation, the European and Developing Countries Clinical Trials Partnership, U.S. Agency for International Development, U.K.
Crook, Angela M.+9 more
core +1 more source
EFFECT OF PARACETAMOL ON THE RENAL CLEARANCE AND URINARY EXCRETION OF ISONIAZID IN GOATS [PDF]
Effect of paracetamol on renal clearance and urinary excretion of isoniazid was investigated in eight healthy adult female goats in two phases. In the first phase, each goat was administered isoniazid orally as a single dose at the rate of 10 mg/kg body ...
T. HUSSAIN, I. JAVED, F. H. KHAN, F. MUHAMMAD, B. ASLAM, S. AHMAD1, I. U. JAN2, A. BASIT AND U. TAHIR3
doaj
Recurrent Cutaneous Tuberculosis in an Immunocompetent 7-Year-Old Male [PDF]
Cutaneous tuberculosis (TB) makes up a small proportion of the 10.4 million cases around the world. Although it is more commonly found in the developing world, cutaneous TB is rarely reported in the developed countries.
Austin, Dena+4 more
core +2 more sources
Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy [PDF]
Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the risk of developing leprosy among contacts by around 60 % in the first 2-3 years after ...
Anthony, Richard+13 more
core +9 more sources
Goal of the study: to investigate the impact of isoniazid combined with silver nanoparticles on the isoniazid resistant strains of tuberculous mycobacteria and the course of experimental of tuberculosis caused by the above strains.Materials and ...
A. V. Zаkhаrov+3 more
doaj +1 more source
Rationing tests for drug-resistant tuberculosis - who are we prepared to miss? [PDF]
BACKGROUND: Early identification of patients with drug-resistant tuberculosis (DR-TB) increases the likelihood of treatment success and interrupts transmission.
A Faustini+35 more
core +4 more sources
Lansoprazole Ameliorates Isoniazid-Induced Liver Injury
Isoniazid is a first-line drug in antitubercular therapy. Isoniazid is one of the most commonly used drugs that can cause liver injury or acute liver failure, leading to death or emergency liver transplantation.
Eri Wakai+5 more
doaj +1 more source