Results 111 to 120 of about 2,381,535 (223)

Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: Identification of a novel mutation in inhA

, 2006
Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region.
Yam, WC, Leung, ETY, Lam, TH, Woo, WL, Ho, PL, Yuen, KY, Seto, WH, Kao, RY   +7 more
core   +1 more source

Multidrug-resistant tuberculosis: rapid detection of resistance to rifampin and high or low levels of isoniazid in clinical specimens and isolates [PDF]

, 2008
The aim of the present study was to evaluate a new improved multiplex polymerase chain reaction (PCR) hybridisation assay to detect multidrug-resistant tuberculosis.
Å. B. Andersen, Andersen, Åse Bengård, Sosnovskaja, A., D. Bang, Vijdea, R., Bang, D., V. Ø. Thomsen, Stegger, M., A. Sosnovskaja, Thomsen, V.O., M. Stegger, R. Vijdea   +11 more
core   +1 more source

Treatment outcomes for isoniazid-monoresistant tuberculosis in Peru, 2012-2014.

PLoS ONE, 2018
BackgroundResistance to isoniazid is the most common form of drug-resistance in tuberculosis. However only a tiny proportion of TB patients in the world have access to isoniazid drug susceptibility testing-the widely implemented Xpert MTB/RIF technology ...
Jose Gabriel Cornejo Garcia, Valentina Antonieta Alarcón Guizado, Alberto Mendoza Ticona, Edith Alarcon, Einar Heldal, David A J Moore   +5 more
doaj   +1 more source

Molecular detection of rifampin, isoniazid, and ofloxacin resistance in Iranian isolates of Mycobacterium tuberculosis by high-resolution melting analysis

, 2018
Mehrandokht Sirous,1,2 Azar Dokht Khosravi,1,2 Mohammad Reza Tabandeh,3 Shokrollah Salmanzadeh,1 Nazanin Ahmadkhosravi,4 Sirus Amini5 1Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of ...
Tabandeh MR, Sirous M, Khosravi AD, Amini S, Salmanzadeh S, Ahmadkhosravi N   +5 more
core  

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, Volume 115, Issue 11, Page 2433-2440, November 2026.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

SNPs leading to rifampicin, isoniazid and pyrazinamide resistance in XDR strains.

, 2015
All strain were resistant to rifampicin (RIF, 1 μg/ml), isoniazid (INH, 1 μg/ml) and pyrazinamide (PZA, 100μg/ml). ‘#’ mutations in the rifampicin- resistance determining region (RRDR), the number in parenthesis indicates the number of MTB isolates from ...
Mridul Nair (590036), Asho Ali (73920), Kim Mallard (362508), Taane G. Clark (106263), Rumina Hasan (73926), Zahra Hasan (73921), Ruth McNerney (227467), Francesc Coll (495630), Arnab Pain (37809), Grant Hill-Cawthorne (696209)   +9 more
core   +1 more source

Missed rifampicin and isoniazid resistance by commercial molecular assays [PDF]

Drug-resistant tuberculosis (TB) has poor outcomes unless resistance is detected early, ideally by commercially available molecular tests. We present a case of occult multidrug-resistant TB where both rifampicin and isoniazid resistance were missed by ...
Richards, L, Ismail, F, Omar, S V, Nel, J   +3 more
core   +1 more source

Drug Resistance Analysis of Pasiniazid against Isoniazid-Resistant, Parasal-Resistant, Isoniazid and Parasal-Resitant, and Multidrug-Resistant

Medicinal Chemistry, 2015
Objective: In view of the high INH resistance, we conducted in vitro drug susceptible test of Isoniazid (INH) and Parasal (PAS) and Pasiniazid (PA) to determine the cross-resistance of the three drugs. Method: The proportion method on Lo¨wenstein–Jensen (L–J) medium was used to conduct antimycobacterial susceptibility testing of INH and PAS and PA to ...
openaire   +1 more source

Genotypic Characterization of Drug Resistance-associated Mutations in Mycobacterium tuberculosis Using Line Probe Assays in Central India

International Journal of Mycobacteriology
Background: Drug-resistant tuberculosis (TB), especially rifampicin-resistant and multidrug-resistant TB, remains a significant public health challenge worldwide.
Antisha Tiwari, Shaina Gaikwad, Vishal Dangi, Falguni Agrawal, Maneesh Singh, Jitendra Singh, Sagar Khadanga, Alkesh Khurana, Shashank Purwar, Debasis Biswas, Anand Kumar Maurya   +10 more
doaj   +1 more source