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Mechanisms for isoniazid action and resistance.
Novartis Foundation symposium, 1999Isoniazid is the most widely used antituberculosis drug. Genetic studies in Mycobacterium smegmatis identified the inhA-encoded, NADH-dependent enoyl acyl carrier protein reductase as the primary target for this drug. A reactive form of isoniazid inhibits InhA by reacting with the NAD(H) cofactor bound to the enzyme active site forming a covalent ...
L, Miesel +3 more
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Relation Between In-Vitro and In-Vivo Resistance to Isoniazid.
Lancet, The, 1952R Knox, J M Robson
exaly
MUTATIONAL STUDIES ON THE ISONIAZID RESISTANCE OF A MYCOBACTERIUM
Japanese Journal of Microbiology, 1960M, TSUKAMURA, K, MIURA, T, ABO
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Streptomycin and isoniazid resistance.
American review of tuberculosis, 2002R S, MITCHELL, W, STEENKEN
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