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Recent Advances in Synthetic Isoquinoline-Based Derivatives in Drug Design [PDF]

Molecules
Compounds based on an isoquinoline scaffold (benzo[c]pyridine) display a broad spectrum of biological activities. In recent years, studies have focused mainly on their anticancer properties.
Łukasz Balewski, Anita Kornicka
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Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists

Molecules, 2021
An expansion of the structure–activity relationship study of CXCR4 antagonists led to the synthesis of a series of isoquinolines, bearing a tetrahydroquinoline or a 3-methylpyridinyl moiety as head group.
Mastaneh Safarnejad Shad, Sandra Claes, Eline Goffin, Tom Van Loy, Dominique Schols, Steven De Jonghe, Wim Dehaen   +6 more
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Dess–Martin Periodinane-Mediated Oxidative Coupling Reaction of Isoquinoline with Benzyl Bromide

Molecules, 2023
Dess–Martin periodinane (DMP) is a broadly applicable oxidant in chemical synthesis. In this work, an efficient and convenient synthesis of N-substituted isoquinolinone derivatives mediated by DMP was achieved through the oxidative coupling reaction of ...
Chunmei Yang, Guoqing Zhang, Senling Tang, Yang Pan, Huawu Shao, Wei Jiao   +5 more
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The unique reactivity of 5,6-unsubstituted 1,4-dihydropyridine in the Huisgen 1,4-diploar cycloaddition and formal [2 + 2] cycloaddition

Beilstein Journal of Organic Chemistry, 2023
The three-component reaction of isoquinolines, dialkyl acetylenedicarboxylates, and 5,6-unsubstituted 1,4-dihydropyridines in acetonitrile at room temperature afforded functionalized isoquinolino[1,2-f][1,6]naphthyridines in good yields and with high ...
Xiu-Yu Chen, Hui Zheng, Ying Han, Jing Sun, Chao-Guo Yan   +4 more
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Synthesis of Fused Quinoline Derivatives With Antiproliferative Activities and Tyrosine Kinases, Pim-1 Kinase Inhibitions

Acta Chimica Slovenica, 2022
Cyclohexan-1,3-dione (1) reacted with either 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2a) or diethyl 3-amino-2-cyanopent-2-enedioate (2b) to give the 5,6,7,8-tetrahydronaphthalene derivatives 3a and 3b, respectively.
Rafat Milad Mohareb, Rehab Ali Ibrahim, Amira Mohamed Elmetwally, Marwa Soliman Gamaan   +3 more
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Recent Advances in the Synthesis of Isoquinoline-Fused Benzimidazoles

Molecules, 2022
This review includes recent developments in the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines with particular attention given to categorizing protocols based on the structural features of the ring architecture and crystallographically characterized ...
Dylan J. Twardy, Kraig A. Wheeler, Béla Török, Roman Dembinski   +3 more
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Partitioning of π-electrons in rings of aza-derivatives of naphthalene [PDF]

Journal of the Serbian Chemical Society, 2007
A recently proposed method for calculating the π-electron contents (EC) of rings of heteroatom-containing polycyclic conjugated molecules was applied to the aza-derivatives of naphthalene.
Gutman Ivan, Furtula Boris, Kovačević Radmila   +2 more
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Mono- and Diamination of 4,6-Dichloropyrimidine, 2,6-Dichloropyrazine and 1,3-Dichloroisoquinoline with Adamantane-Containing Amines

Molecules, 2021
N-heteroaryl substituted adamantane-containing amines are of substantial interest for their perspective antiviral and psychotherapeutic activities. Chlorine atom at alpha-position of N-heterocycles has been substituted by the amino group using convenient
Alisa D. Kharlamova, Anton S. Abel, Alexei D. Averin, Olga A. Maloshitskaya, Vitaly A. Roznyatovskiy, Evgenii N. Savelyev, Boris S. Orlinson, Ivan A. Novakov, Irina P. Beletskaya   +8 more
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Synergistic Effect of the Cationic Peptide Hominin and a New Disinfectant Based on Isoquinoline on Formation of Biofilms in Multidrug-Resistant Staphylococci

Антибиотики и Химиотерапия, 2020
The growing threat of proliferation of biofilm-forming hospital strains of coagulase-negative staphylococci resistant to antibiotics determines the need for an urgent search for new effective antibacterial compounds, as well as the development of methods
L. I. Kononova, I. A. Pyankov, A. A. Smolyak, Yu. V. Shklyaev, V. P. Korobov   +4 more
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Silver-Catalyzed Cascade Cyclization of Amino-NH-1,2,3-Triazoles with 2-Alkynylbenzaldehydes: An Access to Pentacyclic Fused Triazoles

Molecules, 2022
An operationally simple Ag(I)-catalyzed approach for the synthesis of isoquinoline and quinazoline fused 1,2,3-triazoles was developed by a condensation and amination cyclization cascade of amino-NH-1,2,3-triazoles with 2-alkynylbenzaldehydes involving ...
Shuitao Zhang, Jianxin Li, Tiebo Xiao, Baomin Yang, Yubo Jiang   +4 more
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