Results 31 to 40 of about 40,846 (271)
Detection of substrate binding motifs for morphine biosynthetic pathway intermediates in novel wound inducible (R,S)-reticuline 7-O-methyltransferase of Papaver somniferum [PDF]
, 2011 The benzylisoquinoline alkaloids (BIA) comprise a large and diverse group of nitrogen-containing secondary metabolites with about 2500 compounds identified in plants.
Abha Meena +5 more
core +2 more sources
Acta Crystallographica Section E: Crystallographic Communications, 2015 In each of the title isomeric compounds, C9H7.3N·C7H3.7ClNO4, (I), and C9H8N·C7H3ClNO4, (II), of isoquinoline with 3-chloro-2-nitrobenzoic acid and 4-chloro-2-nitrobenzoic acid, the two components are linked by a short hydrogen bond between a base N atom
Kazuma Gotoh, Hiroyuki Ishida
doaj +1 more source
Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin +13 more
core +4 more sources
MoleculesRing-fused azacyclic compounds are important building blocks in the synthesis of natural products and pharmaceutical agents. Herein, we report an effective and valuable one-pot approach to obtaining polycyclic fused δ-lactams from readily available 2 ...
Antonia Di Mola +3 more
doaj +1 more source
Molecules, 2018 A simple procedure for the synthesis of 8-fluoro-3,4-dihydroisoquinoline is described below, based on a directed ortho-lithiation reaction. This key intermediate was then applied in various transformations.
Csilla Hargitai +4 more
doaj +1 more source
Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy
Pharmaceutics, 2022 Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens.
Dorina Amariucai-Mantu +4 more
doaj +1 more source
Organocatalytic synthesis of axially chiral atropisomers [PDF]
, 2017 This review summarises the recent progress made in the organocatalytic synthesis of atropisomeric compounds. Methodologies based on dynamic kinetic resolution and direct access to BINOL-like biaryls are described.
Renzi, P.
core +1 more source
The Role of Hydrogen Bond Interactions in Crystal Formation of Pyrrolo-Azines Alcohols
CrystalsNew secondary alcohols of type Ar-CHOH-hetaryl and MeCHOH-hetaryl, the radical hetaryl being a pyrroloazine, were investigated in solid state by X-ray single-crystal diffraction analysis, Hirshfeld analysis and DFT methods to assess their ...
Marcel Mirel Popa +3 more
doaj +1 more source
Facile Synthesis of 3-Substituted Thiazolo[2,3-α]tetrahydroisoquinolines
Molecules, 2021 It was found that 4-hydroxy-2-butenoic ester (11) could not react with 3,4-dihydro-isoquinoline (4a). Individual addition reactions of γ-mercapto-α,β-unsaturated esters (18) and -unsaturated amide (19) with 3,4-dihydroisoquinolines (4) were carried out ...
Sheng-Han Huang +3 more
doaj +1 more source
Acta Pharmaceutica, 2016 As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6–20, acrylamide 21, thiazolidine 22, thiazoles 23–29 and thiophenes 33–35 bearing a biologically active quinoline nucleus were
Ghorab Mostafa M. +5 more
doaj +1 more source