Results 31 to 40 of about 16,381 (166)

Synthesis and Pharmacological Evaluation of New 3,4-Dihydroisoquinolin Derivatives Containing Heterocycle as Potential Anticonvulsant Agents

Molecules, 2016
Two novel series of 3,4-dihydroisoquinolin with heterocycle derivatives (4a–t and 9a–e) were synthesized and evaluated for their anticonvulsant activity using maximal electroshock (MES) test and pentylenetetrazole (PTZ)-induced seizure test.
Hong-Jian Zhang, Qing-Kun Shen, Chun-Mei Jin, Zhe-Shan Quan   +3 more
doaj   +1 more source

Research Progress on Neuroprotective Effects of Isoquinoline Alkaloids

Molecules, 2023
Neuronal injury and apoptosis are important causes of the occurrence and development of many neurodegenerative diseases, such as cerebral ischemia, Alzheimer’s disease, and Parkinson’s disease. Although the detailed mechanism of some diseases is unknown,
Jinhua Li, Yarong Wu, Shuze Dong, Ye Yu, Yuhao Wu, Benhan Xiang, Qin Li   +6 more
doaj   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Crystal structures of 2-methoxyisoindoline-1,3-dione, 1,3-dioxoisoindolin-2-yl methyl carbonate and 1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-2-yl methyl carbonate: three anticonvulsant compounds

Acta Crystallographica Section E, 2014
The title compounds, C9H7NO3, (1), C10H7NO5, (2), and C14H9NO5, (3), are three potentially anticonvulsant compounds. Compounds (1) and (2) are isoindoline derivatives and (3) is an isoquinoline derivative.
Fortune Ezemobi, Henry North, Kenneth R. Scott, Anthohy K. Wutoh, Ray J. Butcher   +4 more
doaj   +1 more source

Research on synthesis of microwave‐assisted heterocyclic compounds with eco‐friendly solvents and transition metals via C–H activation

Bulletin of the Korean Chemical Society, EarlyView.
This review summarizes microwave‐assisted transition‐metal catalysis for constructing N‐ and O‐heterocycles, highlighting rapid C–H and pre‐activated C–X activation, improved selectivity, and green synthetic efficiency. Abstract Microwave‐assisted organic synthesis provides a rapid and sustainable platform for synthesizing various heterocycles ...
Woo‐Jin Park, Ye Ri Han, Hyejeong Lee
wiley   +1 more source

Crystal structure and Hirshfeld surface analysis of 4′-(2-chlorophenyl)-1′-methyl-3′′-phenyl-7′′,8′′-dihydro-5′′H-dispiro[indoline-3,2′-pyrrolidine-3′,6′′-isoquinoline]-2,5′′-dione

Acta Crystallographica Section E: Crystallographic Communications, 2018
In the title dispiro compound, C32H26ClN3O2, the cyclohexanone ring of the isoquinoline unit has a distorted envelope conformation, with the methylene C atom adjacent to the spiro C atom as the flap.
R. Vishnupriya, C. Selva Meenatchi, J. Suresh, R. V. Sumesh, R. Ranjith Kumar, P. L. Nilantha Lakshman   +5 more
doaj   +1 more source

Research Progress of Polyoxometalate‐Integrated Frameworks: Syntheses, Properties, and Applications

ChemistryEurope, EarlyView.
This review systematically summarizes the integration of polyoxometalates with covalent organic frameworks, metal‐organic frameworks, hydrogen‐bonded organic frameworks, and emerging porous hosts. It highlights synergistic effects, synthesis strategies, and applications in catalysis, energy storage, sensing, and biomedicine, while addressing current ...
De‐Yin Wang, Zhang‐Di Liu, Rui Xing, Zi‐Hao Wei, Zaixiang Zhang, Yang Yang, Jin Zhu   +6 more
wiley   +1 more source

Highly efficient electrochemiluminescence of quinoline and isoquinoline in aqueous solution

Electrochemistry Communications, 2019
This paper reports for the first time the strong cathodic electrochemiluminescence (ECL) behavior of quinoline, isoquinoline and their derivatives in aqueous solution with K2S2O8 as coreactant. The effects of K2S2O8 concentration, pH and scan rate on the
Xiangxiang Qin, Xia Xu, Jing Lu, Yinggui Zhu   +3 more
doaj   +1 more source

Skeletal Editing from Pyridine to Aniline via C‐Insertion and N‐Isomerization

ChemistryEurope, EarlyView.
A concise protocol is presented that converts pyridines into anilines by externalizing the original pyridine nitrogen at either the "ipso" or "ortho" position, which results in para or meta‐primary aniline products. A key carbene‐insertion step precedes nitrogen migration, preserving both ring size and overall structure.
Yun Luo, Jing Dai, Yongchang Wei, Chang Min   +3 more
wiley   +1 more source

1-[3-(4-Chlorophenyl)isoquinolin-1-yl]-3,5-diethyl-1H-pyrazole

Acta Crystallographica Section E, 2010
The title compound, C22H20ClN3, is composed of a dialkyl-substituted pyrazole ring connected to an aryl-substituted isoquinoline ring system with a dihedral angle of 55.8 (1)° between the pyrazole ring and and the isoquinoline ring ...
F. Nawaz Khan, P. Manivel, K. Prabakaran, Venkatesha R. Hathwar, Seik Weng Ng   +4 more
doaj   +1 more source