Results 101 to 110 of about 29,358 (323)
Phytotherapy Research, EarlyView.ABSTRACT Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer ...
Sonali Khanal +9 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2013 Sensitised photolyses of ethoxycarbonyl oximes of aromatic and heteroaromatic ketones yielded iminyl radicals, which were characterised by EPR spectroscopy.
Roy T. McBurney, John C. Walton
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2009 The molluscicidal activity of Hammada scoparia leaf extracts and the principal alkaloids isolated from them (carnegine and N-methylisosalsoline) were tested against the mollusc gastropod, Galba truncatula, the intermediate host of Fasciola hepatica in ...
R Mezghani-Jarraya +3 more
doaj +1 more source
Synthetic strategies for 5- and 6-membered ring azaheterocycles facilitated by iminyl radicals [PDF]
, 2016 The author thanks EaStCHEM for financial support.The totality of chemical space is so immense that only a small fraction can ever be explored. Computational searching has indicated that bioactivity is associated with a comparatively small number of ring ...
Walton, John Christopher
core +2 more sources
Phytotherapy Research, EarlyView.Schematic representation of how phytochemicals modulate miRNA expression to confer neuroprotection in cerebral ischemia. ABSTRACT Phytochemicals gained substantial interest for their protective action in cerebral ischemia. Additionally, there is a growing body of evidence suggesting that miRs play a role in stroke therapy. However, no systematic review
Joanna Rzemieniec +8 more
wiley +1 more source
A novel method for the synthesis of 1-aryltetrahydroisoquinolines [PDF]
, 2017 Carbenium ions generated from substituted benzhydryls using acid catalysis undergo smooth intramolecular trapping by pendant sulfonamide groups to provide excellent yields of 1 ...
Abdel-Fattah, Hanan A. +5 more
core +2 more sources
The Chemical Record, EarlyView.The stabilization of precursors substituted with 2‐, 1‐naphthol via partially aromatic ortho‐quinone methide intermediate was tested with different cyclic imines in [4+2] cycloaddition.8‐Hydroxyquinoline as a formal 1‐naphthol analogue in Mannich reaction was tested.The formed Mannich bases substituted with 2‐ and 1‐naphthol, 5‐chloro‐8 ...
Dóra Hegedűs +3 more
wiley +1 more source
Isoquinolines from the Roots of Thalictrum flavum L. and Their Evaluation as Antiparasitic Compounds
Molecules, 2010 Alkaloids from Thalictrum flavum L. (Ranuculaceae) growing in the Loire valley (France) were isolated and evaluated for their antiplasmodial and leishmanicidal activities.
Pascal Richomme +5 more
doaj +1 more source
Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications
Cell Proliferation, EarlyView.Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su +5 more
wiley +1 more source
Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition
Molecules, 2013 Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent.
Marcel Mirel Popa +4 more
doaj +1 more source