Results 131 to 140 of about 17,105 (265)

Synthesis of Mesoionic Isoquinolines by Rhodium(III)‐Catalyzed C−H Activation

, 2015
Wei Zhang, Chengqi Wang, Hui Lin, Lin Dong, Yan‐Jun Xu   +4 more
openalex   +2 more sources

Novel dual kappa/mu opioid ligands based on a tetrahydroisoquinoline-valine hybrid nucleus

Scientific Reports
Opioid addiction constitutes a significant global health challenge. Kappa opioid receptor (KOP) modulators have demonstrated efficacy in treating resistant drug abuse cases.
Ahmad Abdelwaly, Hesham Safwan, Shamba Chatterjee, Mohamed Elsayed, Khaled M. Darwish, Amar Chittiboyina, Mohamed A. Helal   +6 more
doaj   +1 more source

Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents [PDF]

, 1986
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Cox, O., Elo, Hannu, Kovacic, Peter, Lumme, Paavo, Ryan, Michael D.   +5 more
core   +1 more source

Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria [PDF]

Alexander T. Bakker, Ioli Kotsogianni, Mariana Ávalos, Jeroen M. Punt, Bing Liu, Diana Piermarini, Berend Gagestein, Cornelis J. Slingerland, Le Zhang, Joost Willemse, Leela Ghimire, Richard J. H. B. N. van den Berg, Antonius P. A. Janssen, Tom H. M. Ottenhoff, C. A. A. VAN BOECKEL, Gilles P. van Wezel, Dmitry Ghilarov, Nathaniel I. Martin, Mario van der Stelt   +18 more
openalex   +1 more source

Isoquinoline and quinazoline urea analogues as antagonists for the Human Adenosine A3 receptor [PDF]

, 2000
Frijtag von Drabbe Kunzel, F, Goot, H. van der, Groot, M. de, IJzerman, A.P., Menge, W.M.P.B., Muijlwijk-Koezen, J.E. van, Timmerman, H.   +6 more
core   +2 more sources

Integration of microRNA–mRNA profiles and pathway analysis of plant isoquinoline alkaloid berberine in SGC-7901 gastric cancers cells

, 2018
Yanhong Yang, Na Zhang, Kundong Li, Juan Chen, Lang Qiu, Jufeng Zhang   +5 more
openalex   +2 more sources

Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5 H -thieno[3′,2’:3,4]pyrido[1,2- b ]isoquinolines as novel adenosine 5′-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes

, 2017
Shengbin Zhou, Yanan Duan, Jiang Wang, Jin Zhang, Haifeng Sun, Haowen Jiang, Zhanni Gu, Junhua Tong, Jingya Li, Jia Li, Hong Liu, Jia Li, Hong Liu   +12 more
openalex   +1 more source

Synthesis, Semiempirical, Stereoselectivity and Pharmacological Activity of a New Class of Spiro Pyrrolidine and Isoquinoline Derivatives [PDF]

, 2006
A. V. Londhe, B. Gupta, S. Kohli, P. Pardasani, R. T. Pardasani   +4 more
openalex   +1 more source

Consensus Virtual Screening Identified [1,2,4]Triazolo[1,5‐b]isoquinolines As MELK Inhibitor Chemotypes [PDF]

, 2021
Anita Rácz, Roberta Palkó, Dorottya Csányi, Zsuzsanna Riedl, Dávid Bajusz, György M. Keserű   +5 more
openalex   +1 more source

Fast atom bombardment mass spectrometry of some isoquinoline alkaloids.

, 1988
Yiming Yang, Man-li Dai, Long-Ze Lin
openalex   +2 more sources