Results 131 to 140 of about 29,358 (323)

Berberine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice and Regulates the PI3K‐AKT Pathway: A Network Pharmacology Study

Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.
ABSTRACT In this study, we investigated the therapeutic potential of Berberine (BBR), an anti‐inflammatory agent capable of penetrating the blood–brain barrier, for mitigating postoperative cognitive dysfunction (POCD) in aged mice. BBR was administered at a dose of 10 mg/kg daily for 2 weeks and significantly improved cognitive impairments induced by ...
Xuan Li, Shiyu Meng, Jiayi Liu, Meixian Sun, Mao Zhou, Fengtao Ji, Yu Hong   +6 more
wiley   +1 more source

Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases

Pharmacological Research, 2022
Complex diseases such as neurodegenerative disorders and cancer constitute a growing public health problem due to the rising incidence and lack in effective therapies.
Erika Plazas, Mónica C. Avila M, Diego R. Muñoz, Luis E. Cuca S   +3 more
doaj  

Chiral N-acyliminium ions as new tools in the asymmetric synthesis of CNS-active compounds [PDF]

, 1994
Beutler, Comins, Gray, Hellmann, Irie, K.Th. Wanner, Kiguchi, Wanner, Wanner, Wong   +9 more
core   +1 more source

Concise total syntheses of (–)-jorunnamycin A and (–)-jorumycin enabled by asymmetric catalysis [PDF]

, 2019
The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong gram-positive and -negative antibiotic character.
Allan, Kevin M., Conklin, Dylan, Gilmore, Christopher D., Glibstrup, Emil, Grünanger, Christian U., Haley, Christopher K., Klatte, Max, Lapointe, Guillaume, McDermott, Martina S. J., Negoro, Kenji, Ngamnithiporn, Aurapat, Pototschnig, Gerit M., Slamon, Dennis J., Stoltz, Brian M., Tadross, Pamela M., Virgil, Scott C., Welin, Eric R.   +16 more
core  

Enantioselective palladium(0)-catalyzed C-H arylation strategy for chiral heterocycles [PDF]

, 2017
Transition-metal-catalyzed C-H functionalizations have emerged as complementary and powerful tools to access molecular complexity from widely available starting materials.
Cramer, Nicolai, Saget, Tanguy
core  

Antimony and Mercury Compounds of Quinoline and isoQuinoline. [PDF]

, 1934
RAJENDRA NATH SEN, GOPAL KRISHNA MUKHERJEE   +1 more
openalex   +1 more source

ANALOGUES OF 2,2′-BIPYRIDYL WITH ISOQUINOLINE AND THIAZOLE RINGS. PART II

, 1954
F. R. Crowne, J. G. Breckenridge
openalex   +1 more source

Syntheses of Isoquinoline Derivatives. XVII

, 1952
Tetsuji Kametani, Shinzo Kano
openalex   +2 more sources

A domino reaction for the synthesis of pyrrolo[2,1-a]isoquinolines from 2-aryl-pyrrolidines and alkynes promoted by a four-component catalytic system under aerobic conditions. [PDF]

RSC Adv, 2023
Luo Z, Hu H, Wang C, Yang Z, Wang Y.
europepmc   +1 more source

Synthesis and fluorine-mediated interactions in methanol-encapsulated solid state self-assembly of an isatin-thiazoline hybrid

, 2015
International audienceAn exciting isatin-thiazoline hybrid molecule 2 having -C=N-N=C- linkage has been synthesized in 88% yield by the reaction of 5-fluoroisatin with N-(4-fluorophenyl)hydrazinecarbothioamide followed by condensation of the resultant ...
Ahmad, Maqbool, Hadda, Taibi B., Naseer, Muhammad Moazzam, Pervez, Humayun, Toupet, Loic   +4 more
core   +2 more sources