Results 31 to 40 of about 17,105 (265)

Synthesis and Contractile Activity of Substituted 1,2,3,4-Tetrahydroisoquinolines

Molecules, 2011
A series of different 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydro-isoquinolines was synthesized in high yields from different ketoamides.
Iliyana Stefanova, Plamen Zagorchev, Stoyanka Nikolova, Dimo Aladjov, Iliyan Ivanov   +4 more
doaj   +1 more source

Deoxygenative C2-heteroarylation of quinoline N-oxides: facile access to α-triazolylquinolines

Beilstein Journal of Organic Chemistry, 2021
A metal- and additive-free, highly efficient, step-economical deoxygenative C2-heteroarylation of quinolines and isoquinolines was achieved from readily available N-oxides and N-sulfonyl-1,2,3-triazoles. A variety of α-triazolylquinoline derivatives were
Geetanjali S. Sontakke, Rahul K. Shukla, Chandra M. R. Volla   +2 more
doaj   +1 more source

Facile Synthesis of Tricyclic 1,2,4-Oxadiazolines-Fused Tetrahydro-Isoquinolines from Oxime Chlorides with 3,4-Dihydroisoquinoline Imines

Molecules, 2022
A mild and efficient strategy for the synthesis of tricyclic 1,2,4-oxadiazolines-fused tetrahydro-isoquinolines derivatives via [3 + 2] cycloaddition reaction is reported.
Kaikai Wang, Yanli Li, Wei Zhang, Rongxiang Chen, Xueji Ma, Mingyue Wang, Nan Zhou   +6 more
doaj   +1 more source

A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy

Beilstein Journal of Organic Chemistry, 2017
Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization ...
Taofeng Shao, Zhiming Gong, Tianyi Su, Wei Hao, Chao Che   +4 more
doaj   +1 more source

7-Acetyl-8-(4-chlorophenyl)-3-ethylsulfanyl-6-hydroxy-1,6-dimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

IUCrData, 2017
In the title compound, C22H23ClN2O2S, the chlorophenyl ring is inclined to the pyridine ring of the isoquinoline ring system by 79.78 (4)°. The cyclohexane ring adopts a flattened boat conformation.
Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt, Etify A. Bakhite, Mustafa R. Albayati   +4 more
doaj   +1 more source

The unique reactivity of 5,6-unsubstituted 1,4-dihydropyridine in the Huisgen 1,4-diploar cycloaddition and formal [2 + 2] cycloaddition

Beilstein Journal of Organic Chemistry, 2023
The three-component reaction of isoquinolines, dialkyl acetylenedicarboxylates, and 5,6-unsubstituted 1,4-dihydropyridines in acetonitrile at room temperature afforded functionalized isoquinolino[1,2-f][1,6]naphthyridines in good yields and with high ...
Xiu-Yu Chen, Hui Zheng, Ying Han, Jing Sun, Chao-Guo Yan   +4 more
doaj   +1 more source

Anti-Alphaviral Alkaloids: Focus on Some Isoquinolines, Indoles and Quinolizidines

Molecules, 2022
The discovery and the development of safe and efficient therapeutics against arthritogenic alphaviruses (e.g., chikungunya virus) remain a continuous challenge.
Anne-Laure Sandenon Seteyen, Emmanuelle Girard-Valenciennes, Axelle Septembre-Malaterre, Philippe Gasque, Pascale Guiraud, Jimmy Sélambarom   +5 more
doaj   +1 more source

Isoquinolin-5-amine

Acta Crystallographica Section C Crystal Structure Communications, 2012
The title compound, C9H8N2, presents two almost identical independent molecules in the asymmetric unit, both of them exhibiting an extremely planar isoquinoline core (maximum r.m.s. deviation = 0.014 Å). The most significant deviation is found in the –NH2groups, which present a noticeable pyramidalization around the N atom, a feature also present in ...
Maria Atria, Ana, Teresa Garland, Maria, Baggio, Ricardo   +2 more
openaire   +4 more sources

Recent advances using [Cp*Co(CO)I2] catalysts as a powerful tool for C-H functionalisation [PDF]

, 2017
Expansion of the synthetic chemists' toolbox is currently a topic of great interest, with successes providing access to novel compounds and more efficient routes towards new and known pharmaceuticals and agrochemicals.
Chirila, Paula G, Whiteoak, Christopher
core   +1 more source

‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach

Molecules, 2013
An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO3 catalyzed ‘one-pot’ cascade process
Jian Li, Hong Liu, Qingya Kong, Hualiang Jiang, Yu Zhou, Baifeng Jiang   +5 more
doaj   +1 more source