Results 31 to 40 of about 15,657 (274)

A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy

Beilstein Journal of Organic Chemistry, 2017
Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization ...
Taofeng Shao, Zhiming Gong, Tianyi Su, Wei Hao, Chao Che   +4 more
doaj   +1 more source

7-Acetyl-8-(4-chlorophenyl)-3-ethylsulfanyl-6-hydroxy-1,6-dimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

IUCrData, 2017
In the title compound, C22H23ClN2O2S, the chlorophenyl ring is inclined to the pyridine ring of the isoquinoline ring system by 79.78 (4)°. The cyclohexane ring adopts a flattened boat conformation.
Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt, Etify A. Bakhite, Mustafa R. Albayati   +4 more
doaj   +1 more source

Hypecoum spp.—Chemistry and Biological Activity of Alkaloids

Diversity, 2023
Genus Hypecoum Tourn. ex L. belongs to the poppy family Papaveraceae and comprises about 19 species occurring in Europe, Northern Africa and Asia.
Nadezhda Kostova, Tsvetelina Doncheva
doaj   +1 more source

Biosynthesis of Isoquinoline Alkaloids [PDF]

Planta Medica, 1979
The isoquinoline alkaloids and their biosynthetic relatives include many compounds which show important physiological properties in animals: dopamine, mescaline, morphine, papaverine, and narcotine are pertinent examples. The biosynthetic routes to the members of this family start from the essential aminoacids tyrosine or phenylalanine. Decarboxylation
openaire   +3 more sources

Tertiary Alcohols as Radical Precursors for the Introduction of Tertiary Substituents into Heteroarenes [PDF]

, 2019
Despite many recent advances in the radical alkylation of electron-deficient heteroarenes since the seminal reports by Minisci and co-workers, methods for the direct incorporation of tertiary alkyl substituents into nitrogen heteroarenes are limited ...
Fishman, DA, Muuronen, M, Overman, LE, Pitre, SP   +3 more
core   +2 more sources

Visible-light photoredox catalyzed synthesis of pyrroloisoquinolines via organocatalytic oxidation/[3 + 2] cycloaddition/oxidative aromatization reaction cascade with Rose Bengal [PDF]

, 2014
Pyrrolo[2,1-a]isoquinoline alkaloids have been prepared via a visible light photoredox catalyzed oxidation/[3 + 2] cycloaddition/oxidative aromatization cascade using Rose Bengal as an organo-photocatalyst.
Lau, Jonathan, Rueping, Magnus, Vila Descals, Carlos   +2 more
core   +3 more sources

Aminomethylation/hydrogenolysis as an alternative to direct methylation of metalated isoquinolines – a novel total synthesis of the alkaloid 7-hydroxy-6-methoxy-1-methylisoquinoline

Beilstein Journal of Organic Chemistry, 2018
Highly-substituted isoquinolines are important scaffolds in syntheses of natural products and in drug development and hence, effective synthetic approaches are required.
Benedikt C. Melzer, Jan G. Felber, Franz Bracher   +2 more
doaj   +1 more source

Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]isoquinolines

Molecules, 2022
A new series of pyrazolo[3,4-g]isoquinoline derivatives, diversely substituted at the 4- or 8-position, were synthesized. The results of the kinase inhibitory potency study demonstrated that the introduction of a bromine atom at the 8-position was ...
Mathilde Defois, Chloé Rémondin, Béatrice Josselin, Lionel Nauton, Vincent Théry, Fabrice Anizon, Sandrine Ruchaud, Francis Giraud, Pascale Moreau   +8 more
doaj   +1 more source

A Facile Palladium Catalysed 3-Component Cascade Route to Functionalised Isoquinolinones and Isoquinolines [PDF]

, 2016
Palladium catalysed three component cascade process, involving coupling of 2-iodobenzoates, -benzaldehydes, or acetophenones with substituted allenes and ammonium tartrate as an ammonium surrogate, provides a novel and facile route to substituted ...
Ackermann, Asano, Boonsong Kongkathip, Chen, Chiarugi, Chou, Chrzanowska, Chueh, Colin W. G. Fishwick, Diederen, Dondas, Elghareeb E. Elboray, Fujiwara, Gai, Gai, Gardiner, Goralski, Grigg, Grigg, Grigg, Grigg, Grigg, Grigg, Groome, Guimond, H. Ali Dondas, Hussien H. Abbas-Temirek, Ingrassia, Iwasa, Jayaraman, Kuo, Larock, Lechel, Lee, Lu, Matveenko, Moustafa F. Aly, Ngampong Kongkathip, Nutthawat Chuanopparat, Ochi, Padwa, Pellicciari, Ronald Grigg, Scott, Sunisa Akkarasamiyo, Too, Wang, Xiao, Yamauchi, Zeni, Álvarez, Álvarez   +51 more
core   +1 more source

Synthesis and Contractile Activity of Substituted 1,2,3,4-Tetrahydroisoquinolines

Molecules, 2011
A series of different 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydro-isoquinolines was synthesized in high yields from different ketoamides.
Iliyana Stefanova, Plamen Zagorchev, Stoyanka Nikolova, Dimo Aladjov, Iliyan Ivanov   +4 more
doaj   +1 more source