Results 61 to 70 of about 17,105 (265)

A Generalized Approach for Distal C–H Arylation of Organic Building Blocks: Unveiling the Role of Counter Anion

Advanced Science, EarlyView.
We report a general strategy for meta‐selective C–H arylation using aryl iodides and a Pd(II)/Pd(IV) catalytic system guided by a removable directing group. DFT and experimental studies reveal that counter anion tuning (acetate to trifluoroacetate) significantly enhances selectivity.
Jagrit Grover, Gaurav Prakash, Astam Mandal, Devika Ghosh, Siddhartha Maiti, Claire Empel, Debabrata Maiti   +6 more
wiley   +1 more source

Stereoselective cycloaddition of 1-glucosyl-1,3-butadienes with tert-butyl 2H-azirine-3-carboxylate, glyoxylates and imines [PDF]

, 2003
Glucosyl dienes 1 have been reacted with the achiral 2H-azirine 4 and with glyoxylates, forming fused structures of type 5 and disaccharide-like compounds 7 with good to excellent selectivity.
Almeida, I. G., Alves, M. José, Fortes, A. Gil, Freitas, A. P.   +3 more
core   +1 more source

Rapid Discovery of Pyrido[3,4- d ]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach [PDF]

, 2016
Monopolar spindle 1 (MPS1) plays a central role in the transition of cells from metaphase to anaphase and is one of the main components of the spindle assembly checkpoint.
Baker, R, Blagg, J, Box, G, Burke, R, Cronin, N, De Haven Brandon, A, Eccles, SA, Faisal, A, Hayes, A, Henley, AT, Hoelder, S, Innocenti, P, Linardopoulos, S, Mak, GW-Y, Matijssen, B, Naud, S, O’Fee, L, Raynaud, FI, Roberts, J, Saville, H, Schmitt, J, Solanki, S, Valenti, M, van Montfort, RLM, Westwood, IM, Woodward, HL   +25 more
core   +2 more sources

Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction

Beilstein Journal of Organic Chemistry, 2014
An efficient one-pot tandem cyclization/[3 + 2] cycloaddition reaction of N’-(2-alkynylbenzylidene)hydrazides with ethyl 4,4,4-trifluorobut-2-ynoate under silver triflate-catalyzed or electrophile-mediated conditions is described.
Xiaoli Zhou, Meiling Liu, Puying Luo, Yingjun Lai, Tangtao Yang, Qiuping Ding   +5 more
doaj   +1 more source

Synthesis and structure - Activity relationship study of potent cytotoxic analogues of the marine alkaloid Lamellarin D [PDF]

, 2014
The marine alkaloid, Lamellarin D (Lam-D), has shown potent cytotoxicity in numerous cancer cell lines, and was recently identified as a potent topoisomerase I inhibitor.
Albericio Palomera, Fernando, Cuevas, Carmen, Francesch, Andrés, Marchal, Antonio, Olsen, Christian A., Pla Queral, Daniel, Álvarez Domingo, Mercedes   +6 more
core   +2 more sources

SYNTHESIS AND ANTIBACTERIAL EVALUATION OF NEW PYRROLO[3’,4’:3,4]PYRROLO[1,2-a]QUINOLINE AND PYRROLO[3',4':3,4]PYRROLO[2,1-a]ISOQUINOLINE DERIVATIVES

Studia Universitatis Babes-Bolyai Chemia, 2019
Two series of new fused pyrrolo[3’,4’:3,4]pyrrolo[1,2-a]quinoline and pyrrolo[3',4':3,4]pyrrolo[2,1-a]isoquinoline derivatives were synthesized and evaluated for the antimicrobial activity.
Cristina M. AL MATARNEH, Monica C. SARDARU, Mircea O. APOSTU, Irina ROSCA, Catalina I. CIOBANU, Ionel I. MANGALAGIU, Ramona DANAC   +6 more
doaj   +1 more source

Cobalt-Catalyzed ortho-C−H functionalization/alkyne annulation of benzylamine derivatives: Access to dihydroisoquinolines [PDF]

, 2017
A practical picolinamide-directed C−H functionalization/alkyne annulation of benzylamine derivatives enabling access to the previously elusive 1,4-dihydroisoquinoline skeleton was developed using molecular O2as the sole oxidant and Co(OAc)2as precatalyst.
Carretero, Juan C., Gómez-Arrayás, Ramón, Martínez, Ángel Manu, Rodríguez, Nuria   +3 more
core   +2 more sources

Synthesis of ([1,2,4]triazolo[4,3-a]pyridin-3-ylmethyl)phosphonates and their benzo derivatives via 5-exo-dig cyclization

Beilstein Journal of Organic Chemistry, 2019
A series of novel 3-methylphosphonylated [1,2,4]triazolo[4,3-a]pyridines was accessed through a 5-exo-dig-type cyclization of chloroethynylphosphonates and commercially available N-unsubstituted 2-hydrazinylpyridines. In addition, 3-methylphosphonylated [
Aleksandr S. Krylov, Artem A. Petrosian, Julia L. Piterskaya, Nataly I. Svintsitskaya, Albina V. Dogadina   +4 more
doaj   +1 more source

2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19 [PDF]

, 2016
We demonstrate a designed scaffold-hop approach to the discovery of 2,8-disubstituted-1,6-naphthyridine- and 4,6-disubstituted-isoquinoline-based dual CDK8/19 ligands.
Blagg, Julian, Burke, Rosemary, Busch, Michael, Clarke, Paul A., Czodrowski, Paul, Eccles, Suzanne A., Esdar, Christina, Honey, Mark A., Mallinger, Aurélie, Musil, Djordje, Poeschke, Oliver, Raynaud, Florence I., Rink, Christian, Rohdich, Felix, Schiemann, Kai, Schneider, Richard, Schwartz, Daniel, Sejberg, Jimmy, Stubbs, Mark, Urbahns, Klaus, Wienke, Dirk, Workman, Paul   +21 more
core   +5 more sources

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source