Results 131 to 140 of about 1,415 (198)

Menaquinone depletion resensitises bedaquiline-resistant tuberculosis

Wetzel J, Dallow J, Davis E, Pearson WH, Daems S, Govaerts M, Hereijgers J, Sprangers J, Truebody B, Maes V, van Hasselt V, Leemans A, Pujari V, Vos A, Martínez Viturro CM, Enrique Gómez J, Peeters M, Gerber M, Chhabra N, Wouters A, Everaerts M, Painter H, Fathima R, Willcocks SJ, Davies C, Raeymaekers V, Clark TG, Draghia-Akli R, Fletcher H, Van Loock M, Hibberd ML, Mostowy S, Crick DC, Pym AS, Samby K, Jackson P, Trabanco AA, Larrouy-Maumus G, Steyn AJ, Stoops B, Dhar N, Aguilar-Pérez C, Lamprecht DA, Wall RJ, Koul A.   +44 more
europepmc   +1 more source

Isothiazoles. Part 12: Isothiazolylphosphonates, a new class of isothiazole dioxides

Tetrahedron, 2001
Abstract We describe a mild and efficient method to prepare 3-amino-4,5-dihydro-5-isothiazolylphosphonates from 3-amino-5-unsubstituted isothiazole dioxides. Starting from 3-amino-5-bromo-isothiazole dioxides either 3-amino-5-isothiazolylphosphonates or 5-diethoxyphosphoryl-4,5-dihydro-4-isothiazolylphosphonates were prepared ...
F. Clerici, M.L. Gelmi, E.R.E. Pini, M. Valle   +3 more
openaire   +3 more sources

3-Chloro-4-(p-Tolyl)Isothiazole-5-Carbonitrile

MolBank, 2023
A reaction of 3-chloroisothiazole-5-carbonitrile with 1-iodo-4-methylbenzene (2 equiv.) produced 3-chloro-4-(p-tolyl)isothiazole-5-carbonitrile in a 60% yield.
Panayiotis A. Koutentis, Andreas S Kalogirou   +1 more
exaly   +2 more sources

In Silico Exploration for Identifying Structure–Activity Relationship of MEK Inhibition and Oral Bioavailability for Isothiazole Derivatives [PDF]

Chemical Biology and Drug Design, 2010
In this study, quantitative structure–activity ⁄prop-erty models are developed for modeling and pre-dicting both MEK inhibitory activity and oral bioavailability of novel isothiazole-4-carboxami-dines.
Georgia Melagraki, Antreas Afantitis, Panayiotis A. Koutentis   +2 more
exaly   +2 more sources

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Isothiazoles

Angewandte Chemie International Edition in English, 1963
AbstractThe ring system of non‐anellated 1,2‐thiazoles (isothiazoles) has only recently become accessible. Four syntheses and numerous interconversions have opened up new routes to compounds which command interest as intermediates and as analogues of natural products and established pharmaceuticals.
F. Hübenett, H. D. Hofmann
openaire   +2 more sources

Anti-HIV Evaluation of Benzo[d]Isothiazole Hydrazones

European Journal of Medicinal Chemistry, 2009
The synthesis and the anti-HIV-1 activity of novel benzo[d]isothiazole hydrazones are reported. Target compounds tested in MT-4 cells cultures for their anti-HIV properties against wild type HIV-1 and HIV strains carrying clinically relevant mutations ...
Roberta Loddo, Matteo Incerti, Paola Vicini   +2 more
exaly   +2 more sources

Isothiazoles

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
D. W. Brown, M. Sainsbury
openaire   +1 more source

Isothiazoles. Part XII. Isothiazole analogues of phenothiazines

Journal of the Chemical Society C: Organic, 1968
The syntheses of isothiazole analogues [(V) and (VI)] of certain phenothiazines and 4-substituted phenothiazines, where the substituent is dialkylaminoalkyl, 1-piperazinylalkyl, or piperidinoalkyl are described. None of these possesses advantageous pharmacological properties.
M. P. L. Caton, R. Slack
openaire   +1 more source

Isothiazoles. Part XIII. Isothiazole sulphides and sulphones

Journal of the Chemical Society C: Organic, 1971
The synthesis of di-isothiazolyl sulphides and their oxidation to sulphoxides and sulphones are described. Isothiazolylphenyl sulphones are prepared by condensation of sodium benzenesulphinates and 5-bromo-3-methyl-4-nitroisothiazole. None of these compounds possess useful biological properties.
M. P. L. Caton, G. C. J. Martin, D. L. Pain   +2 more
openaire   +1 more source

The Chemistry of Isothiazoles

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source