Results 141 to 150 of about 1,415 (198)

Über Isothiazole

Angewandte Chemie, 1963
AbstractDas Ringsystem der nicht annellierten 1.2‐Thiazole (=Isothiazole) ist erst in neuester Zeit zugänglich geworden. Vier Synthesen und zahlreiche Umsetzungen eröffnen neue Wege zu Verbindungen, die als Zwischenprodukte und Analoga zu Naturstoffen und bekannten Pharmazeutika Interesse beanspruchen.
F. Hübenett, F. H. Flock, W. Hansel, H. Heinze, Hd. Hofmann   +4 more
openaire   +1 more source

Condensed isothiazoles. Part 5. Thieno[2,3-d]isothiazoles and thieno[3,2-d]isothiazoles

Journal of the Chemical Society, Perkin Transactions 1, 1980
2,3-Disubstituted thiophens containing a sulphur function (SH, SMe, or SCN) and a carbonyl group (CHO or Ac) have been prepared and converted into thieno[2,3-d or 3,2-d]isothiazoles. Methods used to prepare 1,2-benzisothiazoles are often inapplicable in the thiophen series. For example, an (E)-methyl (2-methylthio-3-thienyl)O-p-nitrobenzoylketoxime (6)
Kenneth Clarke, William Richard Fox, Richard M. Scrowston   +2 more
openaire   +1 more source

Synthesis of isothiazoles

Tetrahedron, 1969
Abstract A method has been devised whereby a substituted isoxazole (I) can be efficiently converted to an isothiazole (III) with a similar substitution pattern. The isoxazole ring is opened by reduction with Raney nickel, and the resulting enamino ketone (II) is treated with phosphorus pentasulfide and chloranil to give the corresponding isothiazole ...
D.N. McGregor, U. Corbin, J.E. Swigor, L.C. Cheney   +3 more
openaire   +1 more source

Synthesis of Stable Isothiazole Carbenes

Angewandte Chemie International Edition, 2007
Whereas stable imi-dazolyl-2- and 1,3-thiazol-2-ylidenes are accessible, isothia-zol-3-ylidenes4 could not beisolated until now.This isnotsurprising when one compares some thermodynamic andkineticcharacteristicsfortypicalcarbenereactionsof1,2,and4(R=H)estimatedbymeansofabinitiocalculations(forthedetails of the quantum chemical calculations, see the Sup-
Janine, Wolf, Winfried, Böhlmann, Matthias, Findeisen, Thomas, Gelbrich, Hans-Jörg, Hofmann, Bärbel, Schulze   +5 more
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ChemInform Abstract: ISOTHIAZOLE 15. MITT. 5‐NITRO‐ISOTHIAZOLE

Chemischer Informationsdienst, 1972
AbstractDurch Diazotieren mit NO[SO4H] und anschließende Nitrierung mit NaNOz/ Cu(I)Cu(II)‐sulfit wird das Aminoisothiazol (I) in das Nitroderivat (II) übergefuhrt, das mit CrO3/H2SO4 zu der Carbonsäure (IIIa) oxidiert wird (widersteht der thermischen Decarboxylierung).
R. J. A. WALSH, K. R. H. WOOLDRIDGE
openaire   +1 more source

ChemInform Abstract: CONDENSED ISOTHIAZOLES. PART 5. THIENO(2,3‐D)ISOTHIAZOLES AND THIEN(3,2‐D)ISOTHIAZOLES

Chemischer Informationsdienst, 1980
AbstractVerschiedene 2,3‐disubstituierte Thienophene wie z.B. (IVa) (Weiterführung in (IVb) und (IVc)) und (IVd) werden dargestellt.
K. CLARKE, W. R. FOX, R. M. SCROWSTON
openaire   +1 more source

Chemistry of Biologically Active Isothiazoles

2007
The isothiazole ring as well as the corresponding benzo- and heterocondensed rings are present in many chemically interesting compounds. The isothiazole ring can be a substituent of a bioactive scaffold or the pharmacophore of bioactive molecules. New compounds have been designed, synthesised and tested towards different biological targets and, in many
F. Clerici, M.L. Gelmi, S. Pellegrino, D. Pocar   +3 more
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Isothiazoles. Part XI. Carbinols, aryl ketones, and aminomethyl derivatives of isothiazoles

Journal of the Chemical Society C: Organic, 1968
Previous work on aryl and hydroxymethyl isothiazoles has been extended and some aroyl isothiazoles and the corresponding secondary alcohols have been prepared. Primary alcohols were obtained by reduction of the known formyl compounds, and secondary alcohols by reactions of Grignard or lithium derivatives with aldehydes.Aroyl derivatives were prepared ...
A. J. Layton, E. Lunt
openaire   +1 more source

Isothiazoles and Benzisothiazoles

2012
In this study, metalation chemistry of isothiazoles, benz[c]isothiazoles, and benz[d]isothiazoles is discussed, and examples of ring metalation, lateral metalation, and utilization of metalated isothiazoles in transition metal-catalyzed coupling reactions are presented.
openaire   +1 more source

The vibrational spectrum of isothiazole

Spectrochimica Acta, 1964
Abstract The infrared spectrum of isothiazole vapour has been measured between 4000 and 400 cm−1 under high resolution. The assignment of the fundamental modes, based on the rotational envelope of the vapour bands and on the previous assignments for isoxazole and isoxazole-d3 is discussed.
S. Califano, F. Piacenti, G. Sbrana
openaire   +1 more source