Results 101 to 110 of about 17,966 (155)

Editorial: Glucosinolate Metabolites: Bioavailability, Bioactivity and Clinical Variability

Frontiers in Nutrition, 2021
Donato Angelino, Elizabeth H. Jeffery
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Chemoprevention by isothiocyanates

Journal of Cellular Biochemistry, 1995
Naturally occurring and synthetic isothiocyanates are among the most effective chemopreventive agents known. A wide variety of isothiocyanates prevents cancer in the rat lung, mammary gland, esophagus, liver, small intestine, colon, and bladder. Mechanistic studies have shown that this chemopreventive activity is due to favorable modification of phase ...
Stephen S. Hecht
exaly   +3 more sources

INHIBITION OF CARCINOGENESIS BY ISOTHIOCYANATES*

Drug Metabolism Reviews, 2000
Isothiocyanates occur as conjugates in a wide variety of cruciferous vegetables. Consumption of normal amounts of these vegetables results in the uptake of substantial quantities of isothiocyanates. These naturally occurring isothiocyanates as well as many synthetic analogs can be powerful inhibitors of carcinogenesis in laboratory animals ...
Stephen S. Hecht
exaly   +3 more sources

The reaction of fluorescein isothiocyanate with thiols: A method for assay of isothiocyanates

Analytical Biochemistry, 1983
The reversible formation of dithiourethanes from fluorescein isothiocyanate and mercaptoethanol or mercaptoethylamine has been studied. It is shown that it is possible to use the reaction as the basis for a spectrophotometric titration of a number of isothiocyanates with mercaptoethanol.
N Michael Green, N M Green
exaly   +3 more sources

Genotoxic effects of allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC)

Chemico-Biological Interactions, 2000
Two isothiocyanates (ITCs) commonly found in human diet, allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC), were tested for genotoxic effects in a battery of assays: Salmonella/microsome assay with TA 98 and TA 100, differential DNA repair assay with E. coli and micronucleus (MN) induction assay with human derived Hep G2 cells. Albeit to
Fekadu Kassie, Siegfried Knasmüller
exaly   +3 more sources

A Convenient Synthesis of Tertiary Isothiocyanates and Acyl Isothiocyanates Using Phosphoryl Isothiocyanate

Synthetic Communications, 1990
Abstract Phosphoryl isothiocyanate, PO(NCS)3, reacts readily with tertiary alcohols and carboxylic acids, giving the respective tertiary isothiocyanates and acyl isothiocyanates in good yields and purity.
Ladislav Kniežo, Juraj Bernát
openaire   +1 more source

Chemopreventive Functions of Isothiocyanates

Drug News & Perspectives, 2005
Numerous animal and epidemiological studies have demonstrated that consumption of cruciferous vegetables is inversely correlated with the cancer incidence. Strong anticarcinogenic activities of cruciferous vegetables are attributed to the high abundance of glucosinolates.
Young-Sam, Keum, Woo-Sik, Jeong, Ah-Ng Tony, Kong   +2 more
openaire   +2 more sources

Synthesis of Isothiocyanates: An Update

Synthesis, 2019
Isothiocyanates (ICTs) are a group of molecules that can be used for many different purposes, they exhibit anticancer, antimicrobial, antibiotic, and anti-inflammatory properties. The synthesis of isothiocyanates has been a focus of many researchers for nearly the past 100 years.
Kayla Eschliman, Stefan Bossmann
openaire   +2 more sources

Isothiocyanates and Xenobiotic Detoxification

Molecular Nutrition & Food Research, 2018
AbstractThe potential of isothiocyanates to antagonize the carcinogenicity of structurally diverse chemicals has been established in animals. A feasible mechanism of action involves protecting DNA by reducing the availability of the genotoxic metabolites of chemical carcinogens by either inhibiting their generation and/or stimulating their ...
Abdull Razis, Ahmad Faizal, Konsue, Nattaya, Ioannides, Costas   +2 more
openaire   +3 more sources

Synthesis of isothiocyanate-derived mercapturic acids

European Journal of Medicinal Chemistry, 2003
Twelve mercapturic acids derived from saturated and unsaturated aliphatic and aromatic isothiocyanates were synthesised, by adding isothiocyanate to a solution of N-acetyl-L-cysteine and sodium bicarbonate, in a typical yield of 77%. Isothiocyanates were
Hans Verhagen, Gordon J F Chittenden
exaly   +1 more source