Results 121 to 130 of about 183,701 (312)
Advanced Science, EarlyView.A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu +5 more
wiley +1 more source
, 2018 An accurate, sensitive, precise and simple method was developed utilizing Gas Chromatography for the quantitative analysis of benzyl isothicyanate in Siwak extract and dental care herbal products claimed to contain Siwak.
Maged Saad Abdel-Kader +3 more
core +1 more source
isoThiocyanates. XXIV. (+)-, (-)-, and (+-)-alpha-Methylbenzyl isoThiocyanate. [PDF]
Acta Chemica Scandinavica, 1957 Anders Kjær +4 more
openaire +1 more source
Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
Advanced Science, EarlyView.This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
, 2012 [[abstract]]Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in ...
;Tsou, Mei-Fen;Peng, Ching-Tien;Shil, Mu-Chin;楊家欣;Yang, Jai-Sing;呂啟誠;Lu, Chi-Cheng;江若華;Chiang, Jo-Hua;吳長霖;Wu, Chang-Lin;林景彬;Lin, Jing-Pin;羅琦;Lo, Chyi;范宗宸;Fan, Ming-Jen;鍾景光;Chung, Jing-Gung
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Pharmacological ResearchIn recent years, isothiocyanates (ITCs), bioactive compounds primarily derived from Brassicaceae vegetables and herbs, have gained significant attention within the biomedical field due to their versatile biological effects. This comprehensive review provides an in-depth exploration of the therapeutic potential and individual biological mechanisms of ...
Cosima C. Hoch +8 more
openaire +3 more sources
Advanced Science, EarlyView.A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu +10 more
wiley +1 more source
Advanced Science, EarlyView.PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang +17 more
wiley +1 more source
Efficacy of isothiocyanate-based compounds on different forms of persistent pain
, 2018 Elena Lucarini,1 Laura Micheli,1 Alma Martelli,2 Lara Testai,2 Vincenzo Calderone,2 Carla Ghelardini,1 Lorenzo Di Cesare Mannelli1 1Pharmacology and Toxicology Section, Department of Neuroscience, Psychology, Drug Research, and Child Health (Neurofarba),
Martelli A +6 more
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Advanced Science, EarlyView.A novel optical thermometer exploits the rare UV emission of Yb2+ ions in a SrB4O7 host, enabling highly sensitive, non‐contact temperature measurements from 80 to 420 K. The applied multiple linear regression (MLR) analysis results in a multiple increase in the resulting temperature sensitivity.
Fang Zhao +6 more
wiley +1 more source