Results 141 to 150 of about 247,107 (303)

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Efficient microwave-assisted synthetic protocols and in silico behaviour prediction of per-substituted β-cyclodextrins [PDF]

, 2013
Ashton, Boffa, Boger, Boobbyer, C. Villalonga-Barber, Cintas, Cruciani, Cruciani, Diaz-Moscoso, Favretto, G. Cravotto, G. Ermondi, Gadelle, Goodford, Guillo, Heck, K. Martina, Kotkova, Kraus, L. Rinaldi, M. Caporaso, Madhavan, Martina, Matsui, Matsui, Memişoğlu, Ortiz Mellet, Ortiz-Mellet, Rekharsky, Szejtli, Tagaki, Tagaki, Vandevenne, Wade, Wang, Weininger, Yamamura   +36 more
core   +1 more source

Isothiocyanate [PDF]

, 2020
openaire   +1 more source

Use of Restricted Nursing and a Bovine Appeasing Substance on the Welfare, Growth Performance, and Response to Vaccination of Beef Calves at Weaning

Animal Research and One Health, EarlyView.
The effects of restricted nursing (RN) and the administration of a bovine appeasing substance (BAS) on days −8 and 0 in relation to weaning were evaluated. Both strategies were effective in improving the growth performance of beef calves. Regarding welfare, BAS ‐especially on day 0‐ was more effective than RN.
Denise E. Mussalafo, Marcelo Vedovatto, Aylpy R. D. Santos, Dalton M. Oliveira, Fabiana A. M. Sterza, Mariana Santos, Helena B. C. R. Batista, Jaíne G. Garcia, Andréa R. D. L. Souza   +8 more
wiley   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, EarlyView.
Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and posttranscriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron splicing ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

Editorial Note: Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Macrophage‐targeted cerium‐tannic acid metal‐polyphenol framework nanoenzyme promotes in situ heart valves regeneration through adaptive immunomodulation

BMEMat, EarlyView.
A novel nanoenzyme based on cerium ions‐tannic acid metal‐polyphenol framework (FCT) has been developed and loaded onto DHVs for targeting M1 macrophages to reduce their ROS level and reprogram macrophage phenotype, thereby eliminating inflammation, promoting endothelialization and adaptive matrix remodeling of scaffolds, offering a promising strategy ...
Peng Song, Yunlong Wu, Xing Chen, Yafei Liu, Mengna Dong, Jiawei Shi, Xichi Wang, Nianguo Dong, Weihua Qiao, Qin Wang   +9 more
wiley   +1 more source

Isothiocyanate-mediated cyclization of phage-displayed peptides enables discovery of macrocyclic binders. [PDF]

Sci Adv
Bai L, Dan T, Cheng P, Yang X, Xiang H, Zhai W, Chen Y, Huang R, Wang Q, Li K, Gao J, Lei X.   +11 more
europepmc   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source