Results 231 to 240 of about 254,991 (338)

Proof of Pharmacology, Safety, and Pharmacokinetics of the Novel TRPA1 Antagonist BI 1839100: A Randomized, Placebo-Controlled, Parallel Group, First-In-Human Study in Healthy Male Participants. [PDF]

Clin Transl Sci
van Ruissen MCE, van Kraaij SJW, Wolfova J, Herrmann FE, Botilde Y, Wollin L, Klarenbeek NB.   +6 more
europepmc   +1 more source

Patient‐Specific Coculture of S. aureus and P. aeruginosa Enhances Epithelial Barrier Disruption and Virulence in CRS

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease that is associated with polymicrobial infections, often involving S. aureus and P. aeruginosa. It is unclear whether the polymicrobial context plays a role in exacerbating epithelial damage, inflammation, and resistance to therapy. Methods S. aureus and P. aeruginosa (n =
Xiaohan Sun MMed, Mahnaz Ramezanpour, Jordan Hall, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

New Contributions to Deepen the Quality-Based Safety Assessment in the Consumption of Edible Nasturtium Flowers-The Role of Volatilome. [PDF]

Life (Basel)
Perestrelo R, da Graça Lopes M, da Silva AP, Costa MDC, Câmara JS.   +4 more
europepmc   +1 more source

Sequential treatment of phenethyl isothiocyanate increases sensitivity of Temozolomide resistant glioblastoma cells by decreasing expression of MGMT via NF-κB pathway.

, 2019
Zhigang Guo, Han Wang, Jun Wei, Han Liang, Zhaohui Li   +4 more
openalex   +1 more source

The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast

Animal Models and Experimental Medicine, EarlyView.
The flow diagram outlines the chemical induction of breast tumors through a single intraperitoneal dose of MNU. Tumor development was assessed using ultrasound and clinical examination. After 14 weeks, mammary tissue was collected and histologically analyzed to evaluate structural similarities between sows and humans, the carcinogenic potential of MNU,
Claudia Elizabeth Vera‐Tizatl, Arturo Vera‐Hernández, Lorenzo Leija‐Salas, Marco Antonio Vega‐López, María del Carmen Ramírez‐Estudillo, German Isauro Garrido Fariña, Adriana Leticia Vera‐Tizatl   +6 more
wiley   +1 more source

The Enigma of Sponge-Derived Terpenoid Isothiocyanate-Thiocyanate Pairs: A Biosynthetic Proposal. [PDF]

Mar Drugs
Molinski TF.
europepmc   +1 more source

Content of 6-Methylsulfinylhexyl isothiocyanate in Wasabi and Processed Wasabi Products

, 2004
Mitsuyoshi Murata, Misae Uno, Yoko Nagai, Kazuyo Nakagawa, Isao Okunishi   +4 more
openalex   +2 more sources

Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity

Animal Models and Experimental Medicine, EarlyView.
Brefeldin A (BFA) significantly inhibits oocyte release and induces apoptosis in ovarian granulosa cells by disrupting follicular development. It downregulates proliferation‐associated genes, reduces SIRT1/SIRT6 proteins, and upregulates cell cycle inhibitors P21 and P16. Additionally, BFA impairs estrogen synthesis and affects ovarian function through
Yao Jiang, Meng Lv, Haidan Fan, Yonghua Shi, Tao Wang, Penghao Wang, Xiaolong Yuan, Fei Gao, Bin Ma   +8 more
wiley   +1 more source

Microvascular Damage in the Deep Mucosal <i>Lamina Propria</i> Triggers the Onset of Colitis in Dextran Sulfate Sodium-induced Colitis in Mice. [PDF]

In Vivo
Saijo H, Hashimoto H, Arihiro S, Kusakabe M, Okabe M.   +4 more
europepmc   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, EarlyView.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source