Results 261 to 270 of about 254,991 (338)

Defect‐engineered iron single‐site catalysts with tailored atomic coordination for enhanced mild photothermal therapy via triad modulation of apoptosis and ferroptosis

BMEMat, EarlyView.
A defect‐engineered triad catalyst (DMOF‐SNP‐siRNA) has been developed to enhance mild photothermal therapy for cancer treatment by addressing the limitations of heat shock protein overexpression and suboptimal therapeutic outcomes. This synergy induces potent apoptotic and ferroptotic responses, significantly enhancing the photothermal and catalytic ...
Fanghua Zhang, Wendong Liu, Zhe Hao, Haijun Lu, Jinzheng Liu, Huajie Pang, Ruizhong Zhang, Xiyan Li, Zongjie Wang, Libing Zhang   +9 more
wiley   +1 more source

Correction: Chimeric SF-25 monoclonal antibody as a targeted therapy for SLC3A2 in adult T-cell leukemia/lymphoma. [PDF]

Sci Rep
Suzuki S, Lin XY, Hanada S, Uozumi K, Otsuka M, Owatari S, Haraguchi K, Yoshimitsu M, Ishitsuka K, Takahashi H.   +9 more
europepmc   +1 more source

Harnessing Nature: Computational and Experimental Insights Into Ipomoea obscura Metabolites for Bladder Cancer Therapy

Chemistry &Biodiversity, EarlyView.
ABSTRACT Ipomoea obscura (L.), a medicinal plant from the Convolvulaceae family, has been traditionally used to treat various ailments. This study evaluated the in vitro cytotoxicity of its ethanolic leaf extract against human bladder cancer T24 cells and investigated its phytochemical constituents through computational methods.
Saravana Prabha Poochi, Rajamanikandan Sundarraj, Manikandan Vani Raju, Meenakshi Kaniyur Chandrasekaran, Rathi Muthaiyan Ahalliya, Chella Perumal Palanisamy, Gopalakrishnan Velliyur Kanniappan, Benod Kumar Kondapavuluri, Muthu Thiruvengadam   +8 more
wiley   +1 more source

Synergistic targeting of cancer-related proteins by benzyl isothiocyanate and caffeic acid: MLSD and cytotoxic mechanisms in MCF-7 cells. [PDF]

3 Biotech
Rahaman MHA, Azlan NAA, Alam M, Kadir NHA.   +3 more
europepmc   +1 more source

Kinetics of interaction of N epsilon-fluorescein isothiocyanate-lysine-23-cobra alpha-toxin with the acetylcholine receptor

, 1984
Anthony Cheung, David A. Johnson, Palmer Taylor   +2 more
openalex   +1 more source

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

Chemistry &Biodiversity, EarlyView.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Randa M. Bawadi, Ayah Y. Almasri, Marya A. Hamad, Nour A. Hussein, Salem R. Yasin, Abdulrahman M. Saleh   +8 more
wiley   +1 more source

A novel chemoreactive calcilytic for the potential treatment of autosomal dominant hypocalcemia. [PDF]

Acta Pharm Sin B
Dangerfield J, DeBono A, Keller AN, Josephs TM, Shackleford DM, Gregory KJ, Leach K, Capuano B.   +7 more
europepmc   +1 more source

Lack of inhibitory effect of benzyl isothiocyanate on 2-amino-1-methyl-6-phenylimidazo (4,5-b)pyridine (phIp)-induced mammary carcinogenesis in rats.

, 1996
Natsuko Ino, Shigeyuki Sugie, Masami Ohnishi, Hideki Mori   +3 more
openalex   +2 more sources

Nanomolar Affinity Host‐Dye Reporter Pairs from Fluorescently Labeled Oligoarginine Peptides and p‐Sulfonatocalix[4]arene

ChemBioChem, EarlyView.
The dependence of the binding affinity of oligoarginine peptides to p‐sulfonatocalix[4]arene (CX4) on peptide length, C‐terminal functionality, and fluorescent labeling is reported. The fluorescent peptides can be excited in the visible range with common lasers and show nanomolar affinity and efficient quenching upon CX4 binding, which enables their ...
Aparna Pramanik, Mohammad A. Alnajjar, Tristan Wegner, Andreas Hennig   +3 more
wiley   +1 more source

Activation of the CN Single Bond in Iso(thio)cyanates by a Phosphinine‐Borane Lewis Pair: Unravelling a Complex Reaction Network

ChemistryEurope, EarlyView.
The Lewis pair 1, comprising an aromatic phosphinine and the strong Lewis acid B(C6F5)3, selectively activates the CN bonds in tBuNCO and tBuNCS. The experimental and computational studies confirmed the formation of a 1‐tBu‐phosphininium salt, acting as a key intermediate. Unlike classical frustrated Lewis pairs, this method allows the alkylation of
Samantha Frank, Ádám Horváth, Moritz J. Ernst, Simon Steinhauer, Peter Müller, Zoltán Benkő, Christian Müller   +6 more
wiley   +1 more source