Results 51 to 60 of about 59,651 (334)

Molecular Docking of Potential Inhibitors of Broccoli Myrosinase

Molecules, 2018
Glucosinolates are secondary metabolites occurring in Brassicaceae plants whose hydrolysis may yield isothiocyanates, widely recognized as health-promoting compounds. Myrosinase catalyzes this conversion.
J. Román, A. Castillo, A. Mahn
doaj   +1 more source

Co-Catalyzed Transannulation of Pyridotriazoles with Isothiocyanates and Xanthate Esters.

Organic Letters, 2020
An efficient radical transannulation reaction of pyridotriazoles with isothiocyanates and xanthate esters was developed. This method features conversion of pyridotriazoles into two N-fused heterocyclic aromatic systems-imino-thiazolopyridines and oxo ...
Ziyan Zhang, V. Gevorgyan
semanticscholar   +1 more source

Functional activities and biosynthesis of isothiocyanates in Moringa oleifera Lam. and Brassicaceae: an update

Food & Medicine Homology
Isothiocyanates, secondary metabolites primarily derived from cruciferous plants, are known for their distinct flavors in food and diverse biological activities such as anti-tumor, anti-diabetic, neuroprotective, antibacterial, anti-inflammatory, and ...
Zi-Yu Guo, Chen Dai, Jing Xie, Jia Liu, Yang Tian   +4 more
doaj   +1 more source

Epigenetics/Epigenomics and Prevention of Early Stages of Cancer by Isothiocyanates

Cancer Prevention Research, 2020
Cancer is a complex disease and cancer development takes 10–50 years involving epigenetics. Evidence suggests that approximately 80% of human cancers are linked to environmental factors impinging upon genetics/epigenetics.
Rasika R Hudlikar, Lujing Wang, Renyi Wu, Shanyi Li, R. Peter, Ahmad Shannar, P. Chou, Xia Liu, Zhigang Liu, H. Kuo, A. Kong   +10 more
semanticscholar   +1 more source

Dietary glucosinolates derived isothiocyanates: chemical properties, metabolism and their potential in prevention of Alzheimer’s disease

Frontiers in Pharmacology, 2023
Alzheimer’s disease (AD) is the most prevalent form of dementia affecting millions of people worldwide. It is a progressive, irreversible, and incurable neurodegenerative disorder that disrupts the synaptic communication between millions of neurons ...
Farhana Khan, Abhishek Joshi, Hari Prasad Devkota, Vetriselvan Subramaniyan, Vinoth Kumarasamy, Jaya Arora   +5 more
doaj   +1 more source

Influence of Source Materials, Concentration, Gastric Digestion, and Encapsulation on the Bioactive Response of Brassicaceae-Derived Samples against Helicobacter pylori

Microorganisms, 2023
Isothiocyanates may have antibacterial activity against Helicobacter pylori, but there are different variables related to Brassicaceae-derived samples that could affect their efficacy.
Paula Garcia-Ibañez, Jose Manuel Silvan, Diego A. Moreno, Micaela Carvajal, Adolfo J. Martinez-Rodriguez   +4 more
doaj   +1 more source

Biological activity of glucosinolate derived compounds isolated from seed meal of Brassica crops and evaluated as plant and food protection agents [PDF]

, 2007
Glucosinolates are amino acid derived allelochemicals characteristic of plants of the order Capparales. These compounds are present in seeds of agriculturally common Brassica crops in varying quantities depending on the species (ref).
Bellostas, N., Casanova, E., Garcia-Mina, J.M., Hansen, L.M., Jørgensen, L.N., Kudsk, P., Madsen, P.H., Sørensen, H., Sørensen, J.C.   +8 more
core  

Staudinger/aza-Wittig Reaction to Access Nβ-Protected Amino Alkyl Isothiocyanates [PDF]

, 2018
A unified approach to access Nβ-protected amino alkyl isothiocyanates using Nβ-protected amino alkyl azides through a general strategy of Staudinger/aza-Wittig reaction is described.
Durgamma, S., Santhosh, L., Shekharappa, V., Sureshbabu, V.V.   +3 more
core   +1 more source

Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention.

Molecular Nutrition & Food Research, 2018
Bladder cancer is a significant health burden due to its high prevalence, risk of mortality, morbidity, and high cost of medical care. Epidemiologic evidence suggests that diets rich in cruciferous vegetables, particularly broccoli, are associated with ...
B. Abbaoui, C. R. Lucas, K. Riedl, S. Clinton, A. Mortazavi   +4 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source