Results 91 to 100 of about 12,794 (158)

Dose Optimization Design for Randomized Phase II Trials With Toxicity and Efficacy Endpoints

Pharmaceutical Statistics, Volume 25, Issue 5, September/October 2026.
ABSTRACT Several study designs for identifying optimal biological dose (OBD) have been proposed for phase I, II, and I/II clinical trials, considering toxicity and efficacy of anticancer drugs, especially molecular‐targeted therapies and immune checkpoint inhibitors.
Ryuta Tabata, Tomohiro Ohigashi, Takashi Sozu   +2 more
wiley   +1 more source

Effects of different bupivacaine injection speeds on hemodynamic and some other parameters during spinal anesthesia for cesarean section

Medicine Science
Bupivacaine-induced spinal anesthesia is the most commonly used method for cesarean section. However, maternal hypotension may develop as a significant side effect.
Zeliha Korkmaz Disli, Hulya Gundogdu, Leman Acun Delen   +2 more
doaj   +1 more source

Topology‐Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates

Small, Volume 22, Issue 52, 16 September 2026.
Electrostatic topology is shown to program phase separation and internal organization in thermoresponsive intrinsically disordered protein polymer (IDPP) condensates. By comparing oppositely charged IDPPs with a covalent diblock, chain connectivity is revealed to control charge compensation, dense‐phase micropolarity, miscibility, and apparent acid ...
Julio Fernández‐Fernández, Vicente Domínguez‐Arca, Raúl Escribano, Sheila Lorenzo, Sergio Ferrero, Sergio Acosta, José Carlos Rodríguez‐Cabello   +6 more
wiley   +1 more source

Interpretable Soil Water Retention Prediction Using Hierarchical Attention Networks With Uncertainty Quantification

Water Resources Research, Volume 62, Issue 9, September 2026.
Abstract Understanding which soil properties control water retention at different soil moisture states remains critical for predicting soil responses to management and environmental change. Traditional pedotransfer functions predict parameters of equations like van Genuchten's model, but parameter correlations create ill‐posed inverse problems that ...
Teamrat Afewerki Ghezzehei
wiley   +1 more source

PostForecasts.jl: A Julia package for probabilistic forecasting by postprocessing point predictions

SoftwareX
Postprocessing of point predictions is a relatively simple and efficient way to compute probabilistic forecasts, which are the basis of uncertainty assessment for decision support and risk management.
Arkadiusz Lipiecki, Rafał Weron
doaj   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, Volume 293, Issue 17, Page 5383-5395, September 2026.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

A clinical prediction model for central venous catheter-associated bloodstream infections: derivation and validation from the MIMIC-IV cohort

European Journal of Medical Research
Background Central venous catheter-associated bloodstream infections (CVC–BSIs) significantly affect clinical outcomes in critically ill patients. Existing risk prediction models lack comprehensive integration of early clinical indicators.
Bo Song, Guanjun Jiang, Yujia Liu, Dongsheng Cheng   +3 more
doaj   +1 more source

Assessment, External Verification and Modification of Models in Diagnosing Primary Aldosteronism Subtypes

The Journal of Clinical Hypertension, Volume 28, Issue 9, September 2026.
ABSTRACT Diagnostic models are used to identify primary aldosteronism (PA) subtypes, including unilateral primary aldosteronism (UPA) and bilateral primary aldosteronism (BPA), only UPA could be treated through surgery. PA diagnostic models were screened from the NCBI, Embase, and Web of Science databases and assessed using the Prediction Model Risk of
Yingyu Jing, Yifan Zhang, Haonan Guo, Rongrong Hou, Jing Xu, Jingyue Wang, Xingyan Pan, Xinyi Niu, Lin Song, Lili Huang, Jinyan Zhang, Fang Jia, Bo Sun, Ning Wang   +13 more
wiley   +1 more source

Bayesian Inference for Multivariate Monotone Densities

Scandinavian Journal of Statistics, Volume 53, Issue 3, Page 1206-1229, September 2026.
ABSTRACT We consider a nonparametric Bayesian approach to estimation and testing for a multivariate monotone density. Instead of following the conventional Bayesian approach of imposing a prior that satisfies the monotonicity restriction, we place a prior on the step heights via binning and a Dirichlet distribution. The resulting posterior distribution
Kang Wang, Subhashis Ghosal
wiley   +1 more source

High‐pressure homogenization and pH‐shifting modification of hazelnut protein isolates: Functional enhancement, allergenicity reduction, and probiotic microencapsulation performance

Journal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6365-6379, 30 August 2026.
Abstract BACKGROUND Plant‐based proteins, such as hazelnut protein isolates (HPIs), often exhibit limited solubility and functionality, as well as allergenic potential, thereby limiting their applicability in food products. This investigation sought to improve the techno‐functional characteristics of HPI and mitigate its allergenicity via high‐pressure
Ilyas Atalar, Hatice Elen, Osman Gul, Abdullah Kurt, M.Irfan Aksu, Nevzat Konar   +5 more
wiley   +1 more source